Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Juan Maldonado Weng"'
Autor:
Juan Maldonado Weng, Ishita Parikh, Ankur Naqib, Jason York, Stefan J. Green, Steven Estus, Mary Jo LaDu
Publikováno v:
Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-9 (2019)
Abstract Background Alzheimer’s disease (AD) is a fatal neurodegenerative disease. APOE4 is the greatest genetic risk factor for AD, increasing risk up to 15-fold compared to the common APOE3. Importantly, female (♀) APOE4 carriers have a greater
Externí odkaz:
https://doaj.org/article/d8eeb3b3e50d46efa93f3f0cf1e2e7f6
Publikováno v:
Neurobiology of Disease, Vol 139, Iss , Pp 104811- (2020)
The focus on amyloid plaques and neurofibrillary tangles has yielded no Alzheimer’s disease (AD) modifying treatments in the past several decades, despite successful studies in preclinical mouse models. This inconsistency has caused a renewed focus
Externí odkaz:
https://doaj.org/article/1379ff67320a44a3a603417af7830e78
Autor:
Ishita J. Parikh, Janice L. Estus, Diana J. Zajac, Manasi Malik, Juan Maldonado Weng, Leon M. Tai, George E. Chlipala, Mary Jo LaDu, Stefan J. Green, Steven Estus
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Background: Since APOE alleles represent the most impactful genetic risk factors for Alzheimer's disease (AD), their differential mechanism(s) of action are under intense scrutiny. APOE4 is robustly associated with increased AD risk compared to the n
Externí odkaz:
https://doaj.org/article/26645987dc4d42a28f6af9e70b58d52c
Autor:
Ana C. Valencia‐Olvera, Juan Maldonado Weng, Amy Christensen, Mary Jo LaDu, Christian J. Pike
Publikováno v:
Journal of Neuroendocrinology. 35
Alzheimer's disease (AD) is characterized by numerous sexual dimorphisms that impact the development, progression, and probably the strategies to prevent and treat the most common form of dementia. In this review, we consider this topic from a female
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc8132b049fb8e8e8c8867a57154919
https://doi.org/10.1111/jne.13209
https://doi.org/10.1111/jne.13209
Publikováno v:
Prog Mol Biol Transl Sci
Progress in Molecular Biology and Translational Science ISBN: 9780128241431
Progress in Molecular Biology and Translational Science ISBN: 9780128241431
Over the last several decades, a number of mouse models have been generated for mechanistic and preclinical therapeutic research on Alzheimer's disease (AD)-like behavioral impairments and pathology. Acceptance or rejection of these models by the sci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c87b85cd291f485e1274a45550bf99
https://europepmc.org/articles/PMC8163103/
https://europepmc.org/articles/PMC8163103/
Publikováno v:
Neurobiol Dis
Neurobiology of Disease, Vol 139, Iss, Pp 104811-(2020)
Neurobiology of Disease, Vol 139, Iss, Pp 104811-(2020)
The focus on amyloid plaques and neurofibrillary tangles has yielded no Alzheimer’s disease (AD) modifying treatments in the past several decades, despite successful studies in preclinical mouse models. This inconsistency has caused a renewed focus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5d9c1cacc49461c96b7db91bbf8103
https://pubmed.ncbi.nlm.nih.gov/32087290
https://pubmed.ncbi.nlm.nih.gov/32087290
Autor:
Ishita J, Parikh, Janice L, Estus, Diana J, Zajac, Manasi, Malik, Juan, Maldonado Weng, Leon M, Tai, George E, Chlipala, Mary Jo, LaDu, Stefan J, Green, Steven, Estus
Publikováno v:
Frontiers in Immunology
Background: Since APOE alleles represent the most impactful genetic risk factors for Alzheimer's disease (AD), their differential mechanism(s) of action are under intense scrutiny. APOE4 is robustly associated with increased AD risk compared to the n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9976398613de054b0ba56a00bf28c25b
https://pubmed.ncbi.nlm.nih.gov/32117315
https://pubmed.ncbi.nlm.nih.gov/32117315
Autor:
Juan Maldonado Weng, Mary Jo LaDu, Ana Carolina Valencia-Olvera, Jason M. York, Deebika Balu, Aimee James Karstens, Efstathia Loukenas
Publikováno v:
Neurosci Lett
Identified in 1993, APOE4 is the greatest genetic risk factor for Alzheimer's disease (AD), increasing risk up to 15-fold compared to the common variant APOE3. Since the mid 1990's, transgenic (Tg) mice have been developed to model AD pathology and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::691990c049f29e09b6ca0ebc978e6e46
https://pubmed.ncbi.nlm.nih.gov/31150730
https://pubmed.ncbi.nlm.nih.gov/31150730