Zobrazeno 1 - 10 of 75 pro vyhledávání: '"Juan M. Jiménez‐Vacas"'
1
Akademický článek
Clinical value of circulating splicing factors in prostate cancer: SRRM1 as a novel predictive biomarker and therapeutic target
Autor: Antonio J. Montero-Hidalgo, Enrique Gómez-Gómez, Manuel Galán-Cañete, Francisco Porcel-Pastrana, Jesús M. Pérez-Gómez, María Ortega-Bellido, Julia Carrasco-Valiente, Laura Chamorro-Castillo, Juan P. Campos-Hernández, Oriol A. Rangel-Zuñiga, Teresa González-Serrano, Rafael Sánchez-Sánchez, André Sarmento-Cabral, Manuel D. Gahete, Juan M. Jiménez-Vacas, Raúl M. Luque
Publikováno v: Molecular Therapy: Oncology, Vol 32, Iss 4, Pp 200910- (2024)
Prostate cancer (PCa) is the second most common cancer among men worldwide. The main screening tool remains the prostate-specific antigen (PSA), which shows significant limitations, including poor sensitivity/specificity. Therefore, establishing accu
Externí odkaz: https://doaj.org/article/b52521c47f034f6387d9278eeb7e2d1f
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2
Akademický článek
Dysregulation of the miRNome unveils a crosstalk between obesity and prostate cancer: miR-107 asa personalized diagnostic and therapeutic tool
Autor: Vicente Herrero-Aguayo, Prudencio Sáez-Martínez, Juan M. Jiménez-Vacas, M. Trinidad Moreno-Montilla, Antonio J. Montero-Hidalgo, Jesús M. Pérez-Gómez, Juan L. López-Canovas, Francisco Porcel-Pastrana, Julia Carrasco-Valiente, Francisco J. Anglada, Enrique Gómez-Gómez, Elena M. Yubero-Serrano, Alejandro Ibañez-Costa, Aura D. Herrera-Martínez, André Sarmento-Cabral, Manuel D. Gahete, Raúl M. Luque
Publikováno v: Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 1164-1178 (2022)
Prostate-specific antigen (PSA) is the gold-standard marker to screen prostate cancer (PCa) nowadays. Unfortunately, its lack of specificity and sensitivity makes the identification of novel tools to diagnose PCa an urgent medical need. In this conte
Externí odkaz: https://doaj.org/article/d4c45f418c84437da6d022bf2fddd485
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3
Akademický článek
Metformin and simvastatin exert additive antitumour effects in glioblastoma via senescence-state: clinical and translational evidenceResearch in context
Autor: Antonio C. Fuentes-Fayos, Miguel E. G-García, Jesús M. Pérez-Gómez, Antonio J. Montero-Hidalgo, Julia Martín-Colom, Carlos Doval-Rosa, Cristóbal Blanco-Acevedo, Encarnación Torres, Álvaro Toledano-Delgado, Rafael Sánchez-Sánchez, Esther Peralbo-Santaella, Rosa M. Ortega-Salas, Juan M. Jiménez-Vacas, Manuel Tena-Sempere, Miguel López, Justo P. Castaño, Manuel D. Gahete, Juan Solivera, Raúl M. Luque
Publikováno v: EBioMedicine, Vol 90, Iss , Pp 104484- (2023)
Summary: Background: Glioblastoma is one of the most devastating and incurable cancers due to its aggressive behaviour and lack of available therapies, being its overall-survival from diagnosis ∼14-months. Thus, identification of new therapeutic to
Externí odkaz: https://doaj.org/article/3628f45cb0e44068bdcf7e5a46c3c648
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4
Akademický článek
SF3B1 inhibition disrupts malignancy and prolongs survival in glioblastoma patients through BCL2L1 splicing and mTOR/ß-catenin pathways imbalances
Autor: Antonio C. Fuentes-Fayos, Jesús M. Pérez-Gómez, Miguel E. G-García, Juan M. Jiménez-Vacas, Cristóbal Blanco-Acevedo, Rafael Sánchez-Sánchez, Juan Solivera, Joshua J. Breunig, Manuel D. Gahete, Justo P. Castaño, Raúl M. Luque
Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-23 (2022)
Abstract Background Glioblastoma is one of the most devastating cancer worldwide based on its locally aggressive behavior and because it cannot be cured by current therapies. Defects in alternative splicing process are frequent in cancer. Recently, w
Externí odkaz: https://doaj.org/article/302009fc920f44f29ce38b09cfabbfd1
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6
Akademický článek
Comparative Cytotoxic Activity of Hydroxytyrosol and Its Semisynthetic Lipophilic Derivatives in Prostate Cancer Cells
Autor: Antonio J. León-González, Prudencio Sáez-Martínez, Juan M. Jiménez-Vacas, Vicente Herrero-Aguayo, Antonio J. Montero-Hidalgo, Enrique Gómez-Gómez, Andrés Madrona, Justo P. Castaño, José L. Espartero, Manuel D. Gahete, Raúl M. Luque
Publikováno v: Antioxidants, Vol 10, Iss 9, p 1348 (2021)
A high adherence to a Mediterranean diet has been related to numerous beneficial effects in human health, including a lower incidence and mortality of prostate cancer (PCa). Olive oil is an important source of phenolic bioactive compounds, mainly hyd
Externí odkaz: https://doaj.org/article/c09a7cc0dc304780804deebca25018fa
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7
Akademický článek
The oncogenic role of the In1-ghrelin splicing variant in prostate cancer aggressiveness
Autor: Daniel Hormaechea-Agulla, Manuel D. Gahete, Juan M. Jiménez-Vacas, Enrique Gómez-Gómez, Alejandro Ibáñez-Costa, Fernando L-López, Esther Rivero-Cortés, André Sarmento-Cabral, José Valero-Rosa, Julia Carrasco-Valiente, Rafael Sánchez-Sánchez, Rosa Ortega-Salas, María M. Moreno, Natia Tsomaia, Steve M. Swanson, Michael D. Culler, María J. Requena, Justo P. Castaño, Raúl M. Luque
Publikováno v: Molecular Cancer, Vol 16, Iss 1, Pp 1-16 (2017)
Abstract Background The Ghrelin-system is a complex, pleiotropic family composed of several peptides, including native-ghrelin and its In1-ghrelin splicing variant, and receptors (GHSR 1a/b), which are dysregulated in various endocrine-related tumors
Externí odkaz: https://doaj.org/article/0b1c38a711744ff4b8d01d874672de75
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8
Akademický článek
Dysregulation of the splicing machinery is directly associated to aggressiveness of prostate cancer
Autor: Juan M. Jiménez-Vacas, Vicente Herrero-Aguayo, Antonio J. Montero-Hidalgo, Enrique Gómez-Gómez, Antonio C. Fuentes-Fayos, Antonio J. León-González, Prudencio Sáez-Martínez, Emilia Alors-Pérez, Sergio Pedraza-Arévalo, Teresa González-Serrano, Oscar Reyes, Ana Martínez-López, Rafael Sánchez-Sánchez, Sebastián Ventura, Elena M. Yubero-Serrano, María J. Requena-Tapia, Justo P. Castaño, Manuel D. Gahete, Raúl M. Luque
Publikováno v: EBioMedicine, Vol 51, Iss , Pp - (2020)
Background: Dysregulation of splicing variants (SVs) expression has recently emerged as a novel cancer hallmark. Although the generation of aberrant SVs (e.g. AR-v7/sst5TMD4/etc.) is associated to prostate-cancer (PCa) aggressiveness and/or castratio
Externí odkaz: https://doaj.org/article/2ef43292c5e645488d2beac6b2a5afe9
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