Zobrazeno 1 - 10
of 201
pro vyhledávání: '"Juan Méndez"'
Autor:
Susana Llanos, Bruno Di Geronimo, Ester Casajús, Elena Blanco-Romero, Rafael Fernández-Leiro, Juan Méndez
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The COVID-19 pandemic highlighted the need for the rapid development of antiviral therapies. Viral RNA-dependent RNA polymerases (RdRp) are promising targets, and numerous virtual screenings for potential inhibitors were conducted without va
Externí odkaz:
https://doaj.org/article/c3f6737d88c2478690195abeaf125408
Autor:
Patricia Ubieto-Capella, Pilar Ximénez-Embún, Daniel Giménez-Llorente, Ana Losada, Javier Muñoz, Juan Méndez
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114024- (2024)
Summary: Mouse embryonic stem cells (mESCs) in the primed pluripotency state, which resembles the post-implantation epiblast, can be de-differentiated in culture to a naive state that resembles the pre-implantation inner cell mass. We report that pri
Externí odkaz:
https://doaj.org/article/de8baade3db844c4bea1848d82e199f9
Autor:
Teresa Fuertes, Emigdio Álvarez-Corrales, Carmen Gómez-Escolar, Patricia Ubieto-Capella, Álvaro Serrano-Navarro, Antonio de Molina, Juan Méndez, Almudena R. Ramiro, Virginia G. de Yébenes
Publikováno v:
Cell Death and Disease, Vol 14, Iss 10, Pp 1-13 (2023)
Abstract Diffuse large B cell lymphoma (DLBCL) is the most common aggressive B cell lymphoma and accounts for nearly 40% of cases of B cell non-Hodgkin lymphoma. DLBCL is generally treated with R-CHOP chemotherapy, but many patients do not respond or
Externí odkaz:
https://doaj.org/article/9379e2de340e481cb06088a6a79cb0c0
Autor:
Sergio Muñoz, Sonia Barroso, Nibal Badra-Fajardo, José Javier Marqueta-Gracia, María L. García-Rubio, Patricia Ubieto-Capella, Juan Méndez, Andrés Aguilera
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113778- (2024)
Summary: During genome duplication, replication forks (RFs) can be stalled by different obstacles or by depletion of replication factors or nucleotides. A limited number of histone post-translational modifications at stalled RFs are involved in RF pr
Externí odkaz:
https://doaj.org/article/5cd5f967db0f4b3486274166c63a0bf2
Publikováno v:
Cells, Vol 13, Iss 2, p 159 (2024)
The regulated formation and resolution of R-loops is a natural process in physiological gene expression. Defects in R-loop metabolism can lead to DNA replication stress, which is associated with a variety of diseases and, ultimately, with cancer. The
Externí odkaz:
https://doaj.org/article/1316b9e396d14d2ca552216d376e41f5
Publikováno v:
Revista Portuguesa de Educação, Vol 36, Iss 1 (2023)
La deserción universitaria tiene efectos negativos en los planos personal, institucional y económico. Diversos estudios muestran que ésta representa un porcentaje importante del gasto público en Educación Superior, además de originar profesiona
Externí odkaz:
https://doaj.org/article/3900fc43703a44a293f4ab67543558ce
Publikováno v:
Boletín de la Sociedad Española de Cerámica y Vidrio, Vol 60, Iss 2, Pp 74-82 (2021)
A glass-ceramic biomaterial with near-eutectic composition of the pseudo-binary system diopside (CMS2, CaMgSi2O6)–tricalcium phosphate [C3P, Ca3(PO4)2], with a weight composition of 61% CMS2–39% C3P, was synthesized by the so-called “petrurgic
Externí odkaz:
https://doaj.org/article/e0ce9bea82354924b0b84442a3c7cd56
Publikováno v:
Boletín de la Sociedad Española de Cerámica y Vidrio, Vol 60, Iss 2, Pp 83-92 (2021)
The in vitro bioactivity of slightly hypereutectic glass-ceramics of the pseudo-binary system diopside (CMS2, CaMgSi2O6)–tricalcium phosphate [Ca3P, Ca3(PO4)2], was tested in a Simulated Body Fluid (SBF) from 7 to 21 days at pH = 7.3 and 36.5 °C.
Externí odkaz:
https://doaj.org/article/eff20656b0d1426cbae6c7b1f0494f17
Autor:
Fatima del Socorro Torres-Caceres, Juan Méndez-Vergaray, Edith Gissela Rivera-Arellano, Mildred Jénica Ledesma-Cuadros, Yolanda Josefina Huayta-Franco, Edward Flores
Publikováno v:
Tuning Journal for Higher Education, Vol 9, Iss 2 (2022)
The objective of the present systematic review aimed to analyze studies linked to online teaching-learning, digital competence tutoring, and technological tools in virtual education during COVID-19 in higher education. The suggested methodology by th
Externí odkaz:
https://doaj.org/article/b5b15eb72f5b402c95b8f1fba4662e29
Autor:
Ann Liza Piberger, Akhil Bowry, Richard D. W. Kelly, Alexandra K. Walker, Daniel González-Acosta, Laura J. Bailey, Aidan J. Doherty, Juan Méndez, Joanna R. Morris, Helen E. Bryant, Eva Petermann
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Bulky DNA adducts are important replication-blocking lesions. Here the authors reveal that homologous recombination at bulky adducts in mammalian cells involves post-replicative gap repair in a PrimPol dependent manner.
Externí odkaz:
https://doaj.org/article/0f6811ec82d941be9a6362cf200f312d