Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Juan M, Pascual"'
Autor:
Muhammed Shariff, Aksharkumar Dobariya, Obada Albaghdadi, Jacob Awkal, Hadi Moussa, Gabriel Reyes, Mansur Syed, Robert Hart, Cameron Longfellow, Debra Douglass, Tarek Y. El Ahmadieh, Levi B. Good, Vikram Jakkamsetti, Gauri Kathote, Gus Angulo, Qian Ma, Ronnie Brown, Misha Dunbar, John M. Shelton, Bret M. Evers, Sourav Patnaik, Ulrike Hoffmann, Amy E. Hackmann, Bruce Mickey, Matthias Peltz, Michael E. Jessen, Juan M. Pascual
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Selective vascular access to the brain is desirable in metabolic tracer, pharmacological and other studies aimed to characterize neural properties in isolation from somatic influences from chest, abdomen or limbs. However, current methods fo
Externí odkaz:
https://doaj.org/article/f27c134eed2846f4b5ca3dffb16c1331
Autor:
Adrian Avila, Ignacio Málaga, Deepa Sirsi, Saima Kayani, Sharon Primeaux, Gauri A. Kathote, Vikram Jakkamsetti, Raja Reddy Kallem, William C. Putnam, Jason Y. Park, Shlomo Shinnar, Juan M. Pascual
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Fuel influx and metabolism replenish carbon lost during normal neural activity. Ketogenic diets studied in epilepsy, dementia and other disorders do not sustain such replenishment because their ketone body derivatives contain four carbon ato
Externí odkaz:
https://doaj.org/article/cad7acfea0c04d9181199beb577e7f81
Autor:
Aksharkumar Dobariya, Tarek Y. El Ahmadieh, Levi B. Good, Ana G. Hernandez-Reynoso, Vikram Jakkamsetti, Ronnie Brown, Misha Dunbar, Kan Ding, Jesus Luna, Raja Reddy Kallem, William C. Putnam, John M. Shelton, Bret M. Evers, Amirhossein Azami, Negar Geramifard, Stuart F. Cogan, Bruce Mickey, Juan M. Pascual
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/7f766811417c476fada6cdeaa60234a6
Autor:
Jennifer M. Gibson, Anthony Hernandez Vazquez, Kunihiko Yamashiro, Vikram Jakkamsetti, Chongyu Ren, Katherine Lei, Brianne Dentel, Juan M. Pascual, Peter T. Tsai
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113533- (2023)
Summary: Cerebellar dysfunction has been linked to autism spectrum disorders (ASDs). Although cerebellar pathology has been observed in individuals with fragile X syndrome (FXS) and in mouse models of the disorder, a cerebellar functional contributio
Externí odkaz:
https://doaj.org/article/3a39af370f964470a5d947f514fe3734
Autor:
Ignacio Málaga, Adrian Avila, Sharon Primeaux, Raja Reddy Kallem, Charles R. Roe, William C. Putnam, Jason Y. Park, Shlomo Shinnar, Chul Ahn, Juan M. Pascual
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Augmentation of anaplerosis, or replenishment of carbon lost during intermediary metabolic transitions, is desirable in energy metabolism defects. Triheptanoin, the triglyceride of 7-carbon heptanoic acid, is anaplerotic via direct oxidation
Externí odkaz:
https://doaj.org/article/0eda3791dde24b34a03d79eca26f7f88
Autor:
Elysandra M. Solis, Levi B. Good, Rafael Granja Vázquez, Sourav Patnaik, Ana G. Hernandez-Reynoso, Qian Ma, Gustavo Angulo, Aksharkumar Dobariya, Stuart F. Cogan, Joseph J. Pancrazio, Juan M. Pascual, Vikram Jakkamsetti
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Glucose represents the principal brain energy source. Thus, not unexpectedly, genetic glucose transporter 1 (Glut1) deficiency (G1D) manifests with encephalopathy. G1D seizures, which constitute a prominent disease manifestation, often prove refracto
Externí odkaz:
https://doaj.org/article/86266aa5aa284d798db3c4b1c8e80b58
Autor:
Aksharkumar Dobariya, Tarek Y. El Ahmadieh, Levi B. Good, Ana G. Hernandez-Reynoso, Vikram Jakkamsetti, Ronnie Brown, Misha Dunbar, Kan Ding, Jesus Luna, Raja Reddy Kallem, William C. Putnam, John M. Shelton, Bret M. Evers, Amirhossein Azami, Negar Geramifard, Stuart F. Cogan, Bruce Mickey, Juan M. Pascual
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Gyriform mammals display neurophysiological and neural network activity that other species exhibit only in rudimentary or dissimilar form. However, neural recordings from large mammals such as the pig can be anatomically hindered and pharmac
Externí odkaz:
https://doaj.org/article/34c32409f3464360b8cb3413a0b7d4dc
Autor:
Roger N. Rosenberg, Juan M. Pascual
Rosenberg's Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Fifth Edition provides a comprehensive introduction and reference to the foundations and key practical aspects relevant to the majority of neurologic and psychiatric disea
Autor:
Mackenzie Cervenka, Juan M. Pascual, Jong M. Rho, Elizabeth Thiele, Gary Yellen, Vicky Whittemore, Adam L. Hartman
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 8, Pp 1730-1737 (2021)
Abstract Objective Thousands of years after dietary therapy was proposed to treat seizures, how alterations in metabolism relates to epilepsy remains unclear, and metabolism‐based therapies are not always effective. Methods We consider the state of
Externí odkaz:
https://doaj.org/article/1e15fb0a7a6a4961a5cff490e46f79de
Autor:
Vikram Jakkamsetti, William Scudder, Gauri Kathote, Qian Ma, Gustavo Angulo, Aksharkumar Dobariya, Roger N. Rosenberg, Bruce Beutler, Juan M. Pascual
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Time-to-fall off an accelerating rotating rod (rotarod) is widely utilized to evaluate rodent motor performance. We reasoned that this simple outcome could be refined with additional measures explicit in the task (however inconspicuously) to
Externí odkaz:
https://doaj.org/article/6e16eac057f74d9383075a1f4cc92614