Výsledky vyhledávání - "Juan M, Monleón"

Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinol esters as potent and long-acting muscarinic antagonists with potential for minimal systemic exposure after inhaled administration: identification of (3R)-3-{[hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide (aclidinium bromide)

Autor: María, Prat, Dolors, Fernández, M Antonia, Buil, María I, Crespo, Gaspar, Casals, Manuel, Ferrer, Laia, Tort, Jordi, Castro, Juan M, Monleón, Amadeu, Gavaldà, Montserrat, Miralpeix, Israel, Ramos, Teresa, Doménech, Dolors, Vilella, Francisca, Antón, Josep M, Huerta, Sonia, Espinosa, Manuel, López, Sonia, Sentellas, Marisa, González, Joan, Albertí, Victor, Segarra, Alvaro, Cárdenas, Jorge, Beleta, Hamish, Ryder

Publikováno v: Journal of medicinal chemistry. 52(16)

The objective of this work was to discover a novel, long-acting muscarinic M(3) antagonist for the inhaled treatment of chronic obstructive pulmonary disease (COPD), with a potentially improved risk-benefit profile compared with current antimuscarini

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