Free amino acids accelerate the time-dependent inactivation of rat liver nucleotide pyrophosphatase/phosphodiesterase Enpp3 elicited by EDTA

Autor: Ana Romero, Guadalupe Cumplido-Laso, Ascensión Fernández, Javier Moreno, José Canales, Rui Ferreira, Juan López-Gómez, João Meireles Ribeiro, María Jesús Costas, José Carlos Cameselle

Publikováno v: Amino Acids, Vol 57, Iss 1, Pp 1-20 (2024)

Abstract Nucleotide-pyrophosphatases/phosphodiesterases (NPP/PDE) are membrane or secreted Zn2+-metallohydrolases of nucleoside-5´-monophosphate derivatives. They hydrolyze, for instance, ATP and 4-nitrophenyl-dTMP, and belong to the ecto-nucleotide

Externí odkaz: https://doaj.org/article/42c6138bbb244f68a61cfd336c854580

Genetics Variants in the Epoxygenase Pathway of Arachidonic Metabolism Are Associated with Eicosanoids Levels and the Risk of Diabetic Nephropathy

Autor: Nicolás Roberto Robles, Sonia Mota-Zamorano, Guadalupe García-Pino, Guillermo Gervasini, Jose M. Valdivielso, Juan Lopez-Gomez, Luz M. González, Bárbara Cancho

Publikováno v: Journal of Clinical Medicine, Vol 10, Iss 3980, p 3980 (2021)
Journal of Clinical Medicine
Volume 10
Issue 17
Repositorio Abierto de la UdL
Universitad de Lleida

Genes in the epoxygenase pathway of arachidonic acid metabolism leading to vasoactive eicosanoids, mainly 20-hydroxyeicosatetraenoic (20-HETE) and epoxyeicosatrienoic (EETs) acids, have been related to glucose-induced renal damage in preclinical repo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667cde761c9bd3460b89622907bef359
https://www.mdpi.com/2077-0383/10/17/3980

Alpha-1-microglobulin: Prognostic value in chronic kidney disease

Autor: Julian Valladares, Juan Lopez Gomez, I. Cerezo, Nicolás Roberto Robles, Roman Hernandez Gallego, Guadalupe Garcia Pino

Publikováno v: Medicina clinica. 157(8)

Objectives α1-microglobulin (α1M) is a tubular protein used for detecting acute lesions of proximal tubules. This study evaluated the use of urine α1M excretion as a marker of chronic kidney disease progression and life survival. Design and method

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9847d2a01ff6acf53bd4c49bf4b608e2
https://pubmed.ncbi.nlm.nih.gov/33069389

Lack of Correlation of Carotid Intima-Media Index and Peripheral Artery Disease

Autor: Sergio Espuelas Barroso, Paloma Laguna, Nicolás Roberto Robles, Juan Lopez Gomez, Gabriel Collado

Publikováno v: High blood pressurecardiovascular prevention : the official journal of the Italian Society of Hypertension. 25(4)

Increased carotid intima-media thickness (IMT) measurement is usually seen as a surrogate marker of peripheral artery disease (PAD) but there is scarce cumulated evidence to support this view. To evaluate prevalence of increased IMT among patients wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c1661051c5f94fc337cfd0f78f8ddc3
https://pubmed.ncbi.nlm.nih.gov/30251108

Polymorphisms in glucose homeostasis genes are associated with cardiovascular and renal parameters in patients with diabetic nephropathy

Autor: Sonia Mota-Zamorano, Luz M. González, Nicolás R. Robles, José M. Valdivielso, José C. Arévalo-Lorido, Juan López-Gómez, Guillermo Gervasini

Publikováno v: Annals of Medicine, Vol 54, Iss 1, Pp 3039-3051 (2022)

Background Diabetic nephropathy (DN) has become the major cause of end-stage kidney disease and is associated to an extremely high cardiovascular (CV) risk.Methods We screened 318 DN patients for 23 SNPs in four glucose transporters (SLC2A1, SLC2A2,

Externí odkaz: https://doaj.org/article/fc02b76432544e2ba0cf5139d46a9c47