Harmful DNA:RNA hybrids are formed in cis and in a Rad51-independent manner

Autor: Juan Lafuente-Barquero, Maria Luisa García-Rubio, Marta San Martin-Alonso, Belén Gómez-González, Andrés Aguilera

Publikováno v: eLife, Vol 9 (2020)

DNA:RNA hybrids constitute a well-known source of recombinogenic DNA damage. The current literature is in agreement with DNA:RNA hybrids being produced co-transcriptionally by the invasion of the nascent RNA molecule produced in cis with its DNA temp

Externí odkaz: https://doaj.org/article/19769cfdc59247ccbec024a0bc663ef0

Integrative molecular characterisation of gallbladder cancer reveals micro-environment-associated subtypes

Autor: Ann W. Hsing, Alisa M. Goldstein, Stephen J. Chanock, Hyoyoung Choo-Wosoba, Asif Rashid, Juan Carlos Araya, Justo Lorenzo Bermejo, Juan Carlos Roa, Difei Wang, Lei Song, Alison L. Van Dyke, Scott M. Lawrence, Juan Lafuente-Barquero, Colm J O'Rourke, Deepak Kumar Bhatt, Zhiwei Liu, Yu-Tang Gao, Karun Mutreja, Allan Hildesheim, Chirag Nepal, Catterina Ferreccio, Michael Dean, Bin Zhu, Jill Koshiol, DongHyuk Lee, Jesper B. Andersen, Mary E. Olanich

Publikováno v: J Hepatol

Background & Aims Gallbladder cancer (GBC) is the most common type of biliary tract cancer, but the molecular mechanisms involved in gallbladder carcinogenesis remain poorly understood. In this study, we applied integrative genomics approaches to cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e20a633252d139f551e221a4c5370b54
https://doi.org/10.1016/j.jhep.2020.11.033

MicroRNA-27a-3p targets FoxO signalling to induce tumour-like phenotypes in bile duct cells

Autor: Lea Duwe, Patricia Munoz-Garrido, Monika Lewinska, Juan Lafuente-Barquero, Letizia Satriano, Dan Høgdall, Andrzej Taranta, Boye S. Nielsen, Awaisa Ghazal, Matthias S. Matter, Jesus M. Banales, Blanca I. Aldana, Yu-Tang Gao, Jens U. Marquardt, Lewis R. Roberts, Rui C. Oliveira, Jill Koshiol, Colm J. O'Rourke, Jesper B. Andersen

Publikováno v: Duwe, L, Munoz-Garrido, P, Lewinska, M, Lafuente-Barquero, J, Satriano, L, Høgdall, D, Taranta, A, Nielsen, B S, Ghazal, A, Matter, M S, Banales, J M, Aldana, B I, Gao, Y-T, Marquardt, J U, Roberts, L R, Oliveira, R C, Koshiol, J, O'Rourke, C J & Andersen, J B 2022, ' MicroRNA-27a-3p targets FoxO signalling to induce tumour-like phenotypes in bile duct cells ', Journal of Hepatology, vol. 78 . https://doi.org/10.1016/j.jhep.2022.10.012
Journal of Hepatology

Background & Aims: Cholangiocarcinoma (CCA) is a heterogeneous and lethal malignancy, the molecular origins of which remain poorly understood. MicroRNAs (miRs) target diverse signalling pathways, functioning as potent epigenetic regulators of transcr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e66c0650516d2ceadf1aaae8cfc9a5
https://curis.ku.dk/portal/da/publications/microrna27a3p-targets-foxo-signalling-to-induce-tumourlike-phenotypes-in-bile-duct-cells(e2e06416-2bd3-4e90-9573-ab895519c481).html

Harmful DNA:RNA hybrids are formed in cis and in a Rad51-independent manner

Autor: Marta San Martin-Alonso, María L. García-Rubio, Juan Lafuente-Barquero, Belén Gómez-González, Andrés Aguilera

Publikováno v: idUS: Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
Digital.CSIC. Repositorio Institucional del CSIC
instname
idUS. Depósito de Investigación de la Universidad de Sevilla
eLife, Vol 9 (2020)
eLife

DNA:RNA hybrids constitute a well-known source of recombinogenic DNA damage. The current literature is in agreement with DNA:RNA hybrids being produced co-transcriptionally by the invasion of the nascent RNA molecule produced in cis with its DNA temp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc52f2b2735b9e561aea25cf67a1ebe6
https://doi.org/10.7554/elife.56674

Harmful DNA:RNA hybrids are formed in cis and in a Rad51-independent manner

Autor: Belén Gómez-González, Andrés Aguilera, Marta San Martin-Alonso, Juan Lafuente-Barquero

DNA:RNA hybrids constitute a well-known source of recombinogenic DNA damage. The current literature is in agreement with DNA:RNA hybrids being produced co-transcriptionally by the invasion of the nascent RNA molecule producedin ciswith its DNA templa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7d0394b3536e5e162112cd53f708f8