Zobrazeno 1 - 10
of 451
pro vyhledávání: '"Juan L. Iovanna"'
Autor:
Sébastien Vachenc, Jessica Gobbo, Sarah El Moujarrebe, Isabelle Desmoulins, Marine Gilabert, Michelle Beau-Faller, Emmanuel Mitry, Nicolas Girard, Aurélie Bertaut, Nelson Dusetti, Juan L. Iovanna, Rahima Yousfi, Fabien Pierrat, Roman Bruno, Adèle Cueff, Romain Boidot, Philippe Genne
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background Nowadays, evaluation of the efficacy and the duration of treatment, in context of monitoring patients with solid tumors, is based on the RECIST methodology. With these criteria, resistance and/or insensitivity are defined as tumor
Externí odkaz:
https://doaj.org/article/c0d3b85ada7445039f9d9e0a54d385a5
Autor:
Tara L. Hogenson, Hao Xie, William J. Phillips, Merih D. Toruner, Jenny J. Li, Isaac P. Horn, Devin J. Kennedy, Luciana L. Almada, David L. Marks, Ryan M. Carr, Murat Toruner, Ashley N. Sigafoos, Amanda N. Koenig-Kappes, Rachel L.O. Olson, Ezequiel J. Tolosa, Cheng Zhang, Hu Li, Jason D. Doles, Jonathan Bleeker, Michael T. Barrett, James H. Boyum, Benjamin R. Kipp, Amit Mahipal, Joleen M. Hubbard, Temperance J. Scheffler Hanson, Gloria M. Petersen, Surendra Dasari, Ann L. Oberg, Mark J. Truty, Rondell P. Graham, Michael J. Levy, Mojun Zhu, Daniel D. Billadeau, Alex A. Adjei, Nelson Dusetti, Juan L. Iovanna, Tanios S. Bekaii-Saab, Wen Wee Ma, Martin E. Fernandez-Zapico
Publikováno v:
JCI Insight, Vol 7, Iss 22 (2022)
BACKGROUND A patient-derived organoid (PDO) platform may serve as a promising tool for translational cancer research. In this study, we evaluated PDO’s ability to predict clinical response to gastrointestinal (GI) cancers.METHODS We generated PDOs
Externí odkaz:
https://doaj.org/article/f973dfbdbe53458f81a1c8da0742e768
Autor:
Angela J. Mathison, Romica Kerketta, Thiago Milech de Assuncao, Elise Leverence, Atefeh Zeighami, Guillermo Urrutia, Timothy J. Stodola, Marina Pasca di Magliano, Juan L. Iovanna, Michael T. Zimmermann, Gwen Lomberk, Raul Urrutia
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-29 (2021)
Abstract Background Pancreatic ductal adenocarcinoma initiation is most frequently caused by Kras mutations. Results Here, we apply biological, biochemical, and network biology methods to validate GEMM-derived cell models using inducible KrasG12D exp
Externí odkaz:
https://doaj.org/article/ef75ec357b034f33b2c29cbe89799f9e
Autor:
Angélina Acier, Magali Godard, Fanny Gassiot, Pascal Finetti, Marion Rubis, Jonathan Nowak, François Bertucci, Juan L. Iovanna, Richard Tomasini, Pascaline Lécorché, Guillaume Jacquot, Michel Khrestchatisky, Jamal Temsamani, Cédric Malicet, Sophie Vasseur, Fabienne Guillaumond
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Acier et al. investigated a peptide cargo system, the Fc(A680)-VH4127, that targets PDAC through the LDLR cell-surface receptor. The Fc(A680)-VH4127 was found to specifically target spontaneous pancreatic tumors in KICmice, as well as metastatic panc
Externí odkaz:
https://doaj.org/article/5ab9785210c145ccb6dcb8b2d12b4fdb
Autor:
Alessio Bonucci, Martina Palomino-Schätzlein, Paula Malo de Molina, Arantxa Arbe, Roberta Pierattelli, Bruno Rizzuti, Juan L. Iovanna, José L. Neira
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
The intracellular environment is crowded with macromolecules, including sugars, proteins and nucleic acids. In the cytoplasm, crowding effects are capable of excluding up to 40% of the volume available to any macromolecule when compared to dilute con
Externí odkaz:
https://doaj.org/article/4e34d3b00ad74a308779a911a133b13e
Autor:
Guillermo Urrutia, Thiago Milech de Assuncao, Angela J. Mathison, Ann Salmonson, Romica Kerketta, Atefeh Zeighami, Timothy J. Stodola, Volkan Adsay, Burcin Pehlivanoglu, Michael B. Dwinell, Michael T. Zimmermann, Juan L. Iovanna, Raul Urrutia, Gwen Lomberk
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, painful disease with a 5-year survival rate of only 9%. Recent evidence indicates that distinct epigenomic landscapes underlie PDAC progression, identifying the H3K9me pathway as important to
Externí odkaz:
https://doaj.org/article/27246750f4cb4ec1b8c2a0e0e807cec6
Autor:
Masatoshi Murayama, Hirohito Hirata, Makoto Shiraki, Juan L. Iovanna, Takayoshi Yamaza, Toshio Kukita, Toshihisa Komori, Takeshi Moriishi, Masaya Ueno, Tadatsugu Morimoto, Masaaki Mawatari, Akiko Kukita
Publikováno v:
Journal of Cellular Physiology. 238:566-581
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0611b306efb81d20fcf2073a331d8d9
https://doi.org/10.1002/jcp.30949
https://doi.org/10.1002/jcp.30949
Autor:
Matias Estaras, Candido Ortiz-Placin, Alba Castillejo-Rufo, Miguel Fernandez-Bermejo, Gerardo Blanco, Jose M. Mateos, Daniel Vara, Pedro L. Gonzalez-Cordero, Sandra Chamizo, Diego Lopez, Adela Rojas, Isabel Jaen, Noelia de Armas, Gines M. Salido, Juan L. Iovanna, Patricia Santofimia-Castaño, Antonio Gonzalez
Publikováno v:
Journal of Physiology and Biochemistry. 79:235-249
We have investigated the effects of melatonin on major pathways related with cellular proliferation and energetic metabolism in pancreatic stellate cells. In the presence of melatonin (1 mM, 100 µM, 10 µM, or 1 µM), decreases in the phosphorylatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e394beab6bd1c2ed56ff7362c1f7eebe
https://doi.org/10.1007/s13105-022-00930-4
https://doi.org/10.1007/s13105-022-00930-4
Autor:
Bruno Rizzuti, Wenjun Lan, Patricia Santofimia-Castaño, Zhengwei Zhou, Adrián Velázquez-Campoy, Olga Abián, Ling Peng, José L. Neira, Yi Xia, Juan L. Iovanna
Publikováno v:
Biomolecules, Vol 11, Iss 10, p 1453 (2021)
Intrinsically disordered proteins (IDPs) are emerging as attractive drug targets by virtue of their physiological ubiquity and their prevalence in various diseases, including cancer. NUPR1 is an IDP that localizes throughout the whole cell, and is in
Externí odkaz:
https://doaj.org/article/829723173f8e4f40b6d8c2b7f62f353f
Autor:
Patricia Santofimia-Castaño, Bruno Rizzuti, Yi Xia, Olga Abian, Ling Peng, Adrián Velázquez-Campoy, Juan L. Iovanna, José L. Neira
Publikováno v:
Molecular & Cellular Oncology, Vol 6, Iss 5 (2019)
Intrinsically disordered proteins (IDPs) do not have a well-defined structure, but they have key biological tasks in cancer development. By using the disordered cancer-related protein NUPR1 as a proof-of-concept, we have developed a new multidiscipli
Externí odkaz:
https://doaj.org/article/4dc7a46fc6c242d39cd335fd3d3ecb22