Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Juan Juan Zhao"'
Autor:
Juan-Juan Zhao, Xin-Yu Sun, Sai-Ning Tian, Zong-Ze Zhao, Meng-Di Yin, Mei Zhao, Feng Zhang, Si-Ang Li, Zhi-Xue Yang, Wei Wen, Tao Cheng, An Gong, Jian-Ping Zhang, Xiao-Bing Zhang
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-23 (2024)
Abstract Background CRISPR-Cas9 technology has advanced in vivo gene therapy for disorders like hemophilia A, notably through the successful targeted incorporation of the F8 gene into the Alb locus in hepatocytes, effectively curing this disorder in
Externí odkaz:
https://doaj.org/article/6b00ee3c16a94b60a7273e094f61df57
Autor:
Zi-Jun Quan, Si-Ang Li, Zhi-Xue Yang, Juan-Juan Zhao, Guo-Hua Li, Feng Zhang, Wei Wen, Tao Cheng, Xiao-Bing Zhang
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 21, Iss 6, Pp 1221-1236 (2023)
To achieve the enormous potential of gene-editing technology in clinical therapies, one needs to evaluate both the on-target efficiency and unintended editing consequences comprehensively. However, there is a lack of a pipelined, large-scale, and eco
Externí odkaz:
https://doaj.org/article/420cff9498ce4ae0b14827b32d3370f6
Autor:
Zhi-Xue Yang, Ya-Wen Fu, Juan-Juan Zhao, Feng Zhang, Si-Ang Li, Mei Zhao, Wei Wen, Lei Zhang, Tao Cheng, Jian-Ping Zhang, Xiao-Bing Zhang
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 21, Iss 6, Pp 1206-1220 (2023)
A series of clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR associated protein 9 (Cas9) systems have been engineered for genome editing. The most widely used Cas9 is SpCas9 from Streptococcus pyogenes and SaCas9 from Staphyl
Externí odkaz:
https://doaj.org/article/dd9a845d89064b8db6bec0665d9eb342
Autor:
Yi-Jing Tao, Juan-Juan Zhao, Li-Hua Rao, Song Yang, Guo-Liang Zhang, Meng-Meng Guo, Chao Chen, Lin Xu, Peng Lyu
Publikováno v:
Chinese Medical Journal, Vol 134, Iss 15, Pp 1855-1865 (2021)
Abstract. Background:. Endotoxin tolerance (ET) is a protective phenomenon in which pre-treatment with a tolerance dose of lipopolysaccharide (LPS) leads to dramatically elevated survival. Accumulating evidence has shown that peripheral T cells contr
Externí odkaz:
https://doaj.org/article/ac67b5437a2f45bf900d3694d4b0dabb
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 142, Iss , Pp 111995- (2021)
The clinical application of cisplatin was mainly limited by severe nephrotoxicity. Danshensu was the main pharmacological active diterpenoids which extracted from the roots of Salvia milthiorriza Bunge. This study is aimed to investigate the protecti
Externí odkaz:
https://doaj.org/article/82f17844cd394385b18e41828d39fccf
Publikováno v:
BMC Pregnancy and Childbirth, Vol 19, Iss 1, Pp 1-10 (2019)
Abstract Background Gestational diabetes mellitus (GDM) is a risk factor for diabetes mellitus. The 75-g, 2-h oral glucose tolerance test is recommended for mothers with a history of GDM to screen for diabetes in the postnatal period. The aim of this
Externí odkaz:
https://doaj.org/article/5234b4942cdb458f83076130cb6d15ce
Autor:
Feng Zhang, Tao Cheng, Jing Xu, Guo-Hua Li, Juan-Juan Zhao, Mei Zhao, Xiao-Bing Zhang, Meng-Di Yin, Yi-Dan Sun, Xin-Yu Sun, Beldon Zhang, Jian-Ping Zhang, Fei-Ying Meng, Si-Ang Li
Publikováno v:
Human Gene Therapy. 33:404-420
Hemophilia A (HA) is a monogenic disease characterized by plasma clotting factor 8 (F8) deficiency due to F8 mutation. We have been attempting to cure HA permanently using a CRISPR-Cas9 gene-editing strategy. Here, we induced targeted integration of
Autor:
Xing-Cai Wang, Jia-Ni Zhang, Juan-Juan Zhao, Xiao-Meng Guo, Shu-Fang Li, Qing-Xia Zheng, Ping-Ping Liu, Peng Lu, Hai-Yan Fu, Yong-Jie Yu, Yuanbin She
Publikováno v:
Analytical Chemistry.
Data-dependent acquisition (DDA) mode in ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS) can provide massive amounts of MS
Autor:
Juan Fu, Ya-Wen Fu, Juan-Juan Zhao, Zhi-Xue Yang, Si-Ang Li, Guo-Hua Li, Zi-Jun Quan, Feng Zhang, Jian-Ping Zhang, Xiao-Bing Zhang, Chang-Kai Sun
Publikováno v:
Stem Cell Reviews and Reports. 18:1822-1833
Highly efficient gene knockout (KO) editing of CRISPR–Cas9 has been achieved in iPSCs, whereas homology-directed repair (HDR)-mediated precise gene knock-in (KI) and high-level expression are still bottlenecks for the clinical applications of iPSCs
Publikováno v:
Insect Science. 29:539-549
Nutritional mutualism between insects and symbiotic bacteria is widespread. The various sap-feeding whitefly species within the Bemisia tabaci complex associate with the same obligate symbiont (Portiera) and multiple secondary symbionts. It is often