Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Juan Iovanna"'
Autor:
Nicolas Fraunhoffer, Carlos Teyssedou, Patrick Pessaux, Martin Bigonnet, Nelson Dusetti, Juan Iovanna
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundThe utilization of modified FOLFIRINOX (mFFX) therapy has shown notable advancements in patient outcomes in both localized and metastatic PDAC. Nevertheless, the effectiveness of mFFX treatment comes at the cost of elevated toxicity, leadin
Externí odkaz:
https://doaj.org/article/5d3886b6d5794efa8c08f0bd0702209c
Autor:
Gareth Pollin, Angela J. Mathison, Thiago M. de Assuncao, Anju Thomas, Atefeh Zeighami, Ann Salmonson, Hongfei Liu, Guillermo Urrutia, Pallavi Vankayala, Stephen J. Pandol, Johnny C. Hong, Michael T. Zimmermann, Juan Iovanna, Victor X. Jin, Raul Urrutia, Gwen Lomberk
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Introduction: The Euchromatic Histone Methyl Transferase Protein 2 (EHMT2), also known as G9a, deposits transcriptionally repressive chromatin marks that play pivotal roles in the maturation and homeostasis of multiple organs. Recently, we have shown
Externí odkaz:
https://doaj.org/article/3ab3e4841b6348709cd8a96b6f115521
Autor:
Patricia Santofimia-Castaño, Nicolas Fraunhoffer, Xi Liu, Ivan Fernandez Bessone, Marina Pasca di Magliano, Stephane Audebert, Luc Camoin, Matias Estaras, Manon Brenière, Mauro Modesti, Gwen Lomberk, Raul Urrutia, Philippe Soubeyran, Jose Luis Neira, Juan Iovanna
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 3, Pp 475-505 (2024)
Abstract We find that NUPR1, a stress-associated intrinsically disordered protein, induced droplet formation via liquid–liquid phase separation (LLPS). NUPR1-driven LLPS was crucial for the creation of NUPR1-dependent stress granules (SGs) in pancr
Externí odkaz:
https://doaj.org/article/d6378f109e874a1da4c8222d7dc3b37c
Autor:
Charlie Saillard, Flore Delecourt, Benoit Schmauch, Olivier Moindrot, Magali Svrcek, Armelle Bardier-Dupas, Jean Francois Emile, Mira Ayadi, Vinciane Rebours, Louis de Mestier, Pascal Hammel, Cindy Neuzillet, Jean Baptiste Bachet, Juan Iovanna, Nelson Dusetti, Yuna Blum, Magali Richard, Yasmina Kermezli, Valerie Paradis, Mikhail Zaslavskiy, Pierre Courtiol, Aurelie Kamoun, Remy Nicolle, Jerome Cros
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Two tumor (Classical/Basal) and stroma (Inactive/active) subtypes of Pancreatic adenocarcinoma (PDAC) with prognostic and theragnostic implications have been described. These molecular subtypes were defined by RNAseq, a costly technique sens
Externí odkaz:
https://doaj.org/article/e304cfa2926e43c8878ffb49da0cc83f
Autor:
Nicolas Alejandro Fraunhoffer, Analía Meilerman Abuelafia, Brice Chanez, Martin Bigonnet, Odile Gayet, Julie Roques, Eduardo Chuluyan, Nelson Dusetti, Juan Iovanna
Publikováno v:
Cancer Communications, Vol 42, Iss 11, Pp 1212-1216 (2022)
Externí odkaz:
https://doaj.org/article/22b06ccf23c24506a8cd3b2ca74690ce
Publikováno v:
Cancer Communications, Vol 42, Iss 10, Pp 1028-1031 (2022)
Externí odkaz:
https://doaj.org/article/cf00c369bcef40f3b7345681e1e6e8e1
Autor:
Gabriela Reyes-Castellanos, Nadine Abdel Hadi, Scarlett Gallardo-Arriaga, Rawand Masoud, Julie Garcia, Sophie Lac, Abdessamad El Kaoutari, Tristan Gicquel, Mélanie Planque, Sarah-Maria Fendt, Laetitia Karine Linares, Odile Gayet, Fabienne Guillaumond, Nelson Dusetti, Juan Iovanna, Alice Carrier
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106899- (2023)
Summary: Pancreatic ductal adenocarcinoma (PDAC) remains one of the human cancers with the poorest prognosis. Interestingly, we found that mitochondrial respiration in primary human PDAC cells depends mainly on the fatty acid oxidation (FAO) to meet
Externí odkaz:
https://doaj.org/article/a215de16132949808608621f7b7c9ed6
Autor:
Nicolas A. Fraunhoffer, Aura I. Moreno Vega, Analía Meilerman Abuelafia, Marie Morvan, Emilie Lebarbier, Tristan Mary-Huard, Michael Zimmermann, Gwen Lomberk, Raul Urrutia, Nelson Dusetti, Yuna Blum, Remy Nicolle, Juan Iovanna
Publikováno v:
EBioMedicine, Vol 92, Iss , Pp 104602- (2023)
Summary: Background: Systems biology leveraging multi-OMICs technologies, is rapidly advancing development of precision therapies and matching patients to targeted therapies, leading to improved responses. A new pillar of precision oncology lies in t
Externí odkaz:
https://doaj.org/article/58837b6a19e4479d8baab9819e17647f
Autor:
Nicolas A. Fraunhoffer, Analía Meilerman Abuelafia, Martin Bigonnet, Odile Gayet, Julie Roques, Remy Nicolle, Gwen Lomberk, Raul Urrutia, Nelson Dusetti, Juan Iovanna
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-16 (2022)
Abstract Pancreatic ductal adenocarcinoma (PDAC), has recently been found to be a heterogeneous disease, although the extension of its diversity remains to be fully understood. Here, we harmonize transcriptomic profiles derived from both PDAC epithel
Externí odkaz:
https://doaj.org/article/a5b3a69ba8654764938ebaff607fad99
Autor:
Patricia Santofimia-Castaño, Can Huang, Xi Liu, Yi Xia, Stephane Audebert, Luc Camoin, Ling Peng, Gwen Lomberk, Raul Urrutia, Philippe Soubeyran, Jose Luis Neira, Juan Iovanna
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
NUPR1 binds to PARP1 and inhibits PARP1 activity in pancreatic cancer cells, with the NUPR1 inhibitor ZZW-115 abolishing the protective effect of NUPR1, inducing strong hyperPARylation and cell death by mitochondrial dysfunction.
Externí odkaz:
https://doaj.org/article/d4dff7ea9c1b4d8c96c31f2f85e4a617