Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Juan Ignacio Jimenez-Loygorri"'
Autor:
Raquel Gomez-Sintes, Qisheng Xin, Juan Ignacio Jimenez-Loygorri, Mericka McCabe, Antonio Diaz, Thomas P. Garner, Xiomaris M. Cotto-Rios, Yang Wu, Shuxian Dong, Cara A. Reynolds, Bindi Patel, Pedro de la Villa, Fernando Macian, Patricia Boya, Evripidis Gavathiotis, Ana Maria Cuervo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Gomez-Sintes et al. have developed small molecules that selectively activate chaperone-mediated autophagy by stabilizing the interaction between retinoic acid receptor alpha and its co-repressor N-CoR1. They demonstrate the protective effect of boost
Externí odkaz:
https://doaj.org/article/31e22769f6804f2d8f96a489a0f64889
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-17 (2024)
Abstract Background Age-related macular degeneration (AMD) is the leading cause of blindness in elderly people in the developed world, and the number of people affected is expected to almost double by 2040. The retina presents one of the highest meta
Externí odkaz:
https://doaj.org/article/f15f134846cf48cf9a7bbee7e37d29af
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Mitochondrial quality control is finely tuned by mitophagy, the selective degradation of mitochondria through autophagy, and mitochondrial biogenesis. Removal of damaged mitochondria is essential to preserve cellular bioenergetics and prevent detrime
Externí odkaz:
https://doaj.org/article/8757b0b161ac4034a8ce93a997419857
Autor:
Juan Ignacio Jiménez-Loygorri, Beatriz Villarejo-Zori, Álvaro Viedma-Poyatos, Juan Zapata-Muñoz, Rocío Benítez-Fernández, María Dolores Frutos-Lisón, Francisco A. Tomás-Barberán, Juan Carlos Espín, Estela Area-Gómez, Aurora Gomez-Duran, Patricia Boya
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Macroautophagy decreases with age, and this change is considered a hallmark of the aging process. It remains unknown whether mitophagy, the essential selective autophagic degradation of mitochondria, also decreases with age. In our analysis
Externí odkaz:
https://doaj.org/article/28bf1444304f436f93a7c072feecb944
Autor:
Raquel Gomez-Sintes, Qisheng Xin, Juan Ignacio Jimenez-Loygorri, Mericka McCabe, Antonio Diaz, Thomas P. Garner, Xiomaris M. Cotto-Rios, Yang Wu, Shuxian Dong, Cara A. Reynolds, Bindi Patel, Pedro de la Villa, Fernando Macian, Patricia Boya, Evripidis Gavathiotis, Ana Maria Cuervo
Publikováno v:
Nature communications. 13(1)
18 p.-8 fig.
Chaperone-mediated autophagy activity, essential in the cellular defense against proteotoxicity, declines with age, and preventing this decline in experimental genetic models has proven beneficial. Here, we have identified the mecha
Chaperone-mediated autophagy activity, essential in the cellular defense against proteotoxicity, declines with age, and preventing this decline in experimental genetic models has proven beneficial. Here, we have identified the mecha
Autor:
Juan Ignacio Jiménez-Loygorri, Beatriz Villarejo-Zori, Álvaro Viedma-Poyatos, Juan Zapata-Muñoz, Rocío Benítez-Fernández, María Dolores Frutos-Lisón, Francisco A. Tomás-Barberán, Juan Carlos Espín, Estela Area-Gómez, Aurora Gomez-Duran, Patricia Boya
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/f616f1b3148e4e6a9d735457dc48560f
Autor:
Álvaro Sahún-Español, Cristina Clemente, Juan Ignacio Jiménez-Loygorri, Elena Sierra-Filardi, Leticia Herrera-Melle, Aurora Gómez-Durán, Guadalupe Sabio, María Monsalve, Patricia Boya, Alicia G. Arroyo
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Vascular smooth muscle cell (VSMC) proliferation is essential for arteriogenesis to restore blood flow after artery occlusion, but the mechanisms underlying this response remain unclear. Based on our previous findings showing increased VSMC
Externí odkaz:
https://doaj.org/article/81136b27965542ae88667a51280b8dac
Publikováno v:
Cell Stress, Vol 4, Iss 5, Pp 95-98 (2020)
Externí odkaz:
https://doaj.org/article/79bbebd2f9fd4cb59cb7825c4ccf01cf