Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Juan Ignacio, Felice"'
1
Phase 1 repolarization rate defines Ca2+ dynamics and contractility on intact mouse hearts
Autor: Ariel L. Escobar, Juan Ignacio Felice, Emiliano Medei, Micaela Lopez Alarcon, Ainhoa Rodriguez de Yurre
Publikováno v: SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
The Journal of general physiology, vol 151, iss 6
In the heart, Ca2+ influx through L-type Ca2+ channels triggers Ca2+ release from the sarcoplasmic reticulum. In most mammals, this influx occurs during the ventricular action potential (AP) plateau phase 2. However, in murine models, the influx thro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4983d6128594721ac5dba2fda15d5055
https://doi.org/10.1085/jgp.201812269
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2
Determinants of Ca2+ release restitution: Insights from genetically altered animals and mathematical modeling
Autor: Carlos Alfredo Valverde, Evangelia G. Kranias, Leandro A. Diaz-Zegarra, Jorge A. Negroni, Juan Ignacio Felice, Ernesto A. Aiello, Marilén Federico, Elena C. Lascano, Alejandra Cely-Ortiz, Alicia Mattiazzi, Julieta Palomeque, Xander H.T. Wehrens
Publikováno v: The Journal of General Physiology
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
The present work shows that SR Ca2+ load and RYR2 Ca2+ sensitivity are major determinants of Ca2+ release restitution (CRR) after each heartbeat. Mathematical modeling led us to speculate that the velocity of SR Ca2+ refilling might regulate CRR inde
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::badfe85072de9cb42229aa1660c69f52
https://doi.org/10.1085/jgp.201912512
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4
Phospholamban ablation rescues the enhanced propensity to arrhythmias of mice with CaMKII-constitutive phosphorylation of RyR2 at site S2814
Autor: Julieta Palomeque, Gabriela Mazzocchi, Evangelia G. Kranias, Alicia Mattiazzi, D. Fainstein, Darlene G. Skapura, Xander H.T. Wehrens, Mark McCauley, P. N. González, Leandro Matías Sommese, Jorge A. Negroni, P. Contreras, M. N. Di Carlo, Juan Ignacio Felice, Elena C. Lascano, Carlos Alfredo Valverde
Publikováno v: The Journal of Physiology. 594:3005-3030
Key points Mice with Ca(2+) -calmodulin-dependent protein kinase (CaMKII) constitutive pseudo-phosphorylation of the ryanodine receptor RyR2 at Ser2814 (S2814D(+/+) mice) exhibit a higher open probability of RyR2, higher sarcoplasmic reticulum (SR) C
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::746763441678051258a337b9ff0be179
https://doi.org/10.1113/jp271622
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5
Phase 1 repolarization rate defines Ca
Autor: María Micaela, López Alarcón, Ainhoa, Rodríguez de Yurre, Juan Ignacio, Felice, Emiliano, Medei, Ariel L, Escobar
Publikováno v: The Journal of General Physiology
Intact heart physiology assessed by local-field optical techniques helps decipher cardiac function at the organ level. Here, we found that the phase 1 repolarization rate of the mouse ventricular action potential defines contractility by regulating t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::04d7076373715a5395f99e38eb40e8b6
https://pubmed.ncbi.nlm.nih.gov/31000581
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6
Ablation of phospholamban rescues reperfusion arrhythmias but exacerbates myocardium infarction in hearts with Ca2+/calmodulin kinase II constitutive phosphorylation of ryanodine receptors
Autor: Juan Ignacio Felice, Mariano N Di Carlo, Enrique Leo Portiansky, Alejandra Cely-Ortiz, Carlos Alfredo Valverde, Alicia Elvira Consolini, Evangelia G. Kranias, Gabriela Mazzocchi, Alicia Mattiazzi, Xander H.T. Wehrens, Nehuen Salas, Susana M. Mosca, María Inés Ragone, Alejandro Ciocci Pardo
Publikováno v: SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Aims Abnormal Ca2+ release from the sarcoplasmic reticulum (SR), associated with Ca2+-calmodulin kinase II (CaMKII)-dependent phosphorylation of RyR2 at Ser2814, has consistently been linked to arrhythmogenesis and ischaemia/reperfusion (I/R)-induced
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb312af627bc1a43478e0f41e25969aa
http://sedici.unlp.edu.ar/handle/10915/124352
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7
Experimental assessment of a myocyte-based multiscale model of cardiac contractile dysfunction
Autor: Sandra Wray, Edmundo I. Cabrera-Fischer, Juan Ignacio Felice, Pierre Dauby, Elena C. Lascano, Sara Kosta, Jorge A. Negroni
Publikováno v: Journal of theoretical biology. 456
Cardiac contractile dysfunction (CD) is a multifactorial syndrome caused by different acute or progressive diseases which hamper assessing the role of the underlying mechanisms characterizing a defined pathological condition. Mathematical modeling ca
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::877e264ff9693a8c6b33703c2f7b5938
https://pubmed.ncbi.nlm.nih.gov/30063925
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10
Nitration of nitrobenzene in Fenton’s processes
Autor: Juan M. Triszcz, Daniela Nichela, Luciano Carlos, Juan Ignacio Felice, Fernando Sebastián García Einschlag
Publikováno v: Chemosphere. 80:340-345
Previous studies of nitrobenzene (NB) degradation by Fenton and photo-Fenton technologies have demonstrated the formation and accumulation of 1,3-dinitrobenzene (1,3-DNB) as a highly toxic reaction intermediate. In the present study, we analyze the c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b00da7c92e00ac6e9c135de1dea9780d
https://doi.org/10.1016/j.chemosphere.2010.03.034
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