222-G Beyond PD-L1: unraveling the enigma of immunotherapy response in PD-L1 negative

Autor: Juan Gumuzio, Lissete Sanchez-Magraner, James Miles, Fernando Aguirre, Peter J Parker, Veronique Calleja

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)

Externí odkaz: https://doaj.org/article/796bea07b0844bb7b31a8bd99341e37a

The LSD1 inhibitor iadademstat (ORY-1001) targets SOX2-driven breast cancer stem cells: a potential epigenetic therapy in luminal-B and HER2-positive breast cancer subtypes

Autor: Juan Gumuzio, Joaquim Bosch-Barrera, Joan Brunet, Tomás Alarcón, José Antonio Encinar, Elisabet Cuyàs, Sara Verdura, Begoña Martin-Castillo, Angel G. Martin, Javier A. Menendez

Publikováno v: Aging, 2020, vol. 12, núm. 6, p. 4794-4814
Articles publicats (D-CM)
Cuyàs, Elisabet Gumuzio, Juan Verdura, Sara Brunet i Vidal, Joan Bosch Barrera, Joaquim Martin Castillo, Begoña Alarcón, Tomás Encinar, José Antonio Martin, Ángel G. Menéndez Menéndez, Javier Abel 2020 The LSD1 inhibitor iadademstat (ORY-1001) targets SOX2-driven breast cancer stem cells: a potential epigenetic therapy in luminal-B and HER2-positive breast cancer subtypes Aging 12 6 4794 4814
DUGiDocs – Universitat de Girona
instname
RECERCAT (Dipòsit de la Recerca de Catalunya)
Aging (Albany NY)
Dipòsit Digital de la UB
Universidad de Barcelona
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Recercat. Dipósit de la Recerca de Catalunya
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona

Altres ajuts: Fundació Oncolliga Girona, Generalitat Valenciana (PROMETEO/2016/006) SOX2 is a core pluripotency-associated transcription factor causally related to cancer initiation, aggressiveness, and drug resistance by driving the self-renewal an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d98ab54e19cbc63daa5fc721a8a00d2
https://doi.org/10.18632/aging.102887

Extra Virgin Olive Oil Contains a Phenolic Inhibitor of the Histone Demethylase LSD1/KDM1A

Autor: Fabiana S. Scornik, Laura Llorach-Parés, Antonio Segura-Carretero, David Carreras, Elisabet Cuyàs, Elisabet Selga, Javier A. Menendez, Juan Gumuzio, Melchor Sanchez-Martinez, Ramon Brugada, Guillermo J. Pérez, Jesús Lozano-Sánchez, Joaquim Bosch-Barrera, José Antonio Encinar, Angel G. Martin, Sara Verdura

Publikováno v: Nutrients
Nutrients, Vol 11, Iss 7, p 1656 (2019)
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Cuyàs, Elisabet Gumuzio, Juan Lozano Sánchez, Jesús Carreras, David Verdura, Sara Llorach Parés, Laura Sanchez Martinez, Melchor Selga Coma, Elisabet Pérez, Guillermo J. Scornik, Fabiana S. Brugada, Ramon Bosch Barrera, Joaquim Segura Carretero, Antonio Martin, Ángel G. Encinar, José Antonio Menéndez Menéndez, Javier Abel 2019 Extra virgin olive oil contains a phenolic inhibitor of the histone demethylase LSD1/KDM1A Nutrients 11 7 1656
Nutrients, 2019, vol. 11, núm. 7, p. 1656
Articles publicats (D-CM)
DUGiDocs – Universitat de Girona

The lysine-specific histone demethylase 1A (LSD1) also known as lysine (K)-specific demethylase 1A (KDM1A) is a central epigenetic regulator of metabolic reprogramming in obesity-associated diseases, neurological disorders, and cancer. Here, we evalu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59b9870960263ab0c890c5d9b1668874
https://pubmed.ncbi.nlm.nih.gov/31331073

Abstract 5038: Ready to use 3D spheroid cultures as a standard tool to screen for compounds targeting cancer

Autor: Estibaliz Ruiz, Juan Gumuzio, Inés Prieto, Angel G. Martin, Olatz Leis

Publikováno v: Cancer Research. 78:5038-5038

The cancer stem cell (CSC) concept has important implications not only for our understanding of carcinogenesis, but also for the development of cancer therapeutics. There is a growing body of preclinical evidence showing that cancer stem cells contri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc81f6024d3644f9dce18008c1713f61
https://doi.org/10.1158/1538-7445.am2018-5038