Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Juan Galceran"'
Autor:
Hassan Fazilaty, Luciano Rago, Khalil Kass Youssef, Oscar H. Ocaña, Francisco Garcia-Asencio, Aida Arcas, Juan Galceran, M. Angela Nieto
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
EMT is a developmental process that is aberrantly activated in metastasizing cancer cells, but how multiple transcription factors regulate EMT is unclear. Here, the authors uncover a gene regulatory network between Prrx1 and Snail1 that selects EMT m
Externí odkaz:
https://doaj.org/article/08e953ed2ee54167890462b34ebbf788
Autor:
Luciano Rago, Oscar H. Ocaña, Juan Galceran, M. Angela Nieto, Aida Arcas, Hassan Fazilaty, Khalil Kass Youssef, Francisco Garcia-Asencio
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
Dadun. Depósito Académico Digital de la Universidad de Navarra
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
Dadun. Depósito Académico Digital de la Universidad de Navarra
The Epithelial to Mesenchymal Transition (EMT) regulates cell plasticity during embryonic development and in disease. It is dynamically orchestrated by transcription factors (EMT-TFs), including Snail, Zeb, Twist and Prrx, all activated by TGF-β amo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3cd8d368aecb6b0ce0a0988e97eeaf5
http://hdl.handle.net/10261/203222
http://hdl.handle.net/10261/203222
Autor:
M. Angela Nieto, Giuseppe Merla, Santina Venuto, Eva Rodriguez-Aznar, Giuseppe Borsani, Tommaso Mazza, Eugenio Monti, Juan Galceran, Lucia Micale, Stefano Castellana, Marta Manzoni, Carmela Rinaldi, Barbara Mandriani
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Scientific Reports
instname
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Scientific Reports
To orchestrate the genomic response to cellular stress signals, p53 recognizes and binds to DNA containing specific and well-characterized p53-responsive elements (REs). Differences in RE sequences can strongly affect the p53 transactivation capacity
Publikováno v:
Genes & Development. 16:3173-3185
Lymphoid enhancer factor (LEF1), a nuclear mediator of Wnt signaling, is required for the formation of organs that depend on inductive interactions between epithelial and mesenchymal tissues. In previous tissue recombination experiments with normal a
Publikováno v:
Proceedings of the National Academy of Sciences. 98:8668-8673
Members of the LEF-1/TCF family of transcription factors have been implicated in mediating a nuclear response to Wnt signals by association with β-catenin. Consistent with this view, mice carrying mutations in either the Wnt3a gene or in both transc
Publikováno v:
Scopus-Elsevier
Wnt signaling is thought to be mediated via interactions between beta-catenin and members of the LEF-1/TCF family of transcription factors. Here we study the mechanism of transcriptional regulation by LEF-1 in response to a Wnt-1 signal under conditi
Autor:
Javier Fernandez-Martinez, Mireille Tora-Ponsioen, M. Angela Nieto, Eva M. Vela, Juan Galceran, Oscar H. Ocaña
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
10 pages.-- PMID: 19383720 [PubMed].-- Printed version published May 15, 2009.
Supporting information available at: http://jcs.biologists.org/cgi/content/full/122/10/1574/DC1
Notch signalling is used throughout the animal kingdom to spatial
Supporting information available at: http://jcs.biologists.org/cgi/content/full/122/10/1574/DC1
Notch signalling is used throughout the animal kingdom to spatial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::237e88a0001698b7fe1d1dcf3a5cd27a
http://hdl.handle.net/10261/17493
http://hdl.handle.net/10261/17493
Autor:
Tomoko Kokubu, Juan Galceran, Matthias B. Wahl, Chikara Kokubu, Takuo Kubota, Ulrich Heinzmann, Norio Sakai, Rudolf Grosschedl, Kenji Imai, Keiichi Ozono, Masanobu Kawai
Publikováno v:
Development
Development 131, 5469-5480 (2004)
Development 131, 5469-5480 (2004)
Here, we present evidence that Lrp6, a coreceptor for Wnt ligands, is required for the normal formation of somites and bones. By positional cloning,we demonstrate that a novel spontaneous mutation ringelschwanz(rs) in the mouse is caused by a point m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf33485da15ce1a2d340772f77ccacf7
https://hdl.handle.net/21.11116/0000-0007-AC87-F21.11116/0000-0007-AC89-D
https://hdl.handle.net/21.11116/0000-0007-AC87-F21.11116/0000-0007-AC89-D
Publikováno v:
Genes and Development
Wnt signaling, which is mediated by LEF1/TCF transcription factors, has been placed upstream of the Notch pathway in vertebrate somitogenesis. Here, we examine the molecular basis for this presumed hierarchy and show that a targeted mutation of Lef1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e02cfcb6bfd32f696b161e32988a7929
http://hdl.handle.net/10261/308953
http://hdl.handle.net/10261/308953
Publikováno v:
Advances in Down Syndrome Research ISBN: 9783211407769
The “Down syndrome critical region” of human chromosome 21 has been defined based on the analysis of rare cases of partial trisomy 21. Evidence is accumulating that DYRK1A, one of the 20 genes located in this region, is an important candidate gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b63402795842d34f7623371a394caee
https://doi.org/10.1007/978-3-7091-6721-2_12
https://doi.org/10.1007/978-3-7091-6721-2_12