Development of Novel ROCK Inhibitors via 3D-QSAR and Molecular Docking Studies: A Framework for Multi-Target Drug Design

Autor: Milan Beljkas, Milos Petkovic, Ana Vuletic, Ana Djuric, Juan Francisco Santibanez, Tatjana Srdic-Rajic, Katarina Nikolic, Slavica Oljacic

Publikováno v: Pharmaceutics, Vol 16, Iss 10, p 1250 (2024)

Background/Objectives: Alterations in the actin cytoskeleton correlates to tumor progression and affect critical cellular processes such as adhesion, migration and invasion. Rho-associated coiled-coil-containing protein kinases (ROCK1 and ROCK2), imp

Externí odkaz: https://doaj.org/article/bd8868677c294249b17ff5df1ce6bb25

The Roles of Mesenchymal Stromal/Stem Cells in Tumor Microenvironment Associated with Inflammation

Autor: Drenka Trivanović, Jelena Krstić, Ivana Okić Djordjević, Slavko Mojsilović, Juan Francisco Santibanez, Diana Bugarski, Aleksandra Jauković

Publikováno v: Mediators of Inflammation, Vol 2016 (2016)

State of tumor microenvironment (TME) is closely linked to regulation of tumor growth and progression affecting the final outcome, refractoriness, and relapse of disease. Interactions of tumor, immune, and mesenchymal stromal/stem cells (MSCs) have b

Externí odkaz: https://doaj.org/article/2d32cfea93824788a9c1c9a9e8c7b3f7

Stratus Ocean Reference Station (20 degrees S, 85 degrees W), mooring recovery and deployment cruise, R/V Ron Brown cruise 04-11, December 5 - December 24, 2004

Autor: Keir Colbo, Robert Weller, Jeff Lord, Jason Smith, Paul Bouchard, Chris Fairall, Frank Bradley, Dan Wolfe, Efthymios Serpetzoglou, Jason Tomlinson, Alvaro Gustave Vera Tisandie, Juan Francisco Santibanez Bustos

Publikováno v: Stratus Ocean Reference Station (20 degrees S, 85 degrees W), mooring recovery and deployment cruise, R/V Ron Brown cruise 04-11, December 5-December 24, 2004

Funding was provided by the National Oceanic and Atmospheric Administration under Contract Number NA17RJ1225.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31994b6840ea12f1d89b918b4d75c4f4
https://doi.org/10.1575/1912/74

Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation

Autor: Ang Lin, Sven Brandau, Stephan Lang, Luca Cassetta, Kirsten Bruderek, Joanna Skrzeczynska-Moncznik, Oktawia Osiecka, Xiaoying Hu, Ida Marie Rundgren, Kim Santegoets, Utku Horzum, Ana Godinho-Santos, Gennadiy Zelinskyy, Thalia Garcia-Tellez, Sunčica Bjelica, Bartłomiej Taciak, Astrid Olsnes Kittang, Benedikt Höing, Michael Dixon, Verena Müller, Jochen Sven Utikal, Derya Karakoç, Kerim Bora Yilmaz, Emilia Górka, Olympia Evdoxia Anastasiou, Christine Bourgeois, Robert Badura, Monika Kapinska-Mrowiecka, Mirjana Gotic, Mark ter Laan, Esther Kers-Rebel, Magdalena Król, Juan Francisco Santibañez, Michaela Müller-Trutwin, Ulf Dittmer, Ana Espada de Sousa, Güneş Esendağlı, Gosse Adema, Karin Loré, Elisabeth Ersvær, Viktor Umansky, Jeffrey W Pollard, Joanna Cichy

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)

Background Myeloid-derived suppressor cells (MDSC) are a functional myeloid cell subset that includes myeloid cells with immune suppressive properties. The presence of MDSC has been reported in the peripheral blood of patients with several malignant

Externí odkaz: https://doaj.org/article/a204127dcd8f4fbba35c1dcd217e919e

Doxycycline Inhibits IL-17-Stimulated MMP-9 Expression by Downregulating ERK1/2 Activation: Implications in Myogenic Differentiation

Autor: Hristina Obradović, Jelena Krstić, Tamara Kukolj, Drenka Trivanović, Ivana Okić Đorđević, Slavko Mojsilović, Aleksandra Jauković, Gordana Jovčić, Diana Bugarski, Juan Francisco Santibañez

Publikováno v: Mediators of Inflammation, Vol 2016 (2016)

Interleukin 17 (IL-17) is a cytokine with pleiotropic effects associated with several inflammatory diseases. Although elevated levels of IL-17 have been described in inflammatory myopathies, its role in muscle remodeling and regeneration is still unk

Externí odkaz: https://doaj.org/article/b99bf065f0844b7a8938bc475cfc5426