Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Juan Fernando Martinez-Leal"'
Autor:
Carlos M. Galmarini, Maud Martin, Benjamin Pierre Bouchet, María José Guillen-Navarro, Marta Martínez-Diez, Juan Fernando Martinez-Leal, Anna Akhmanova, Pablo Aviles
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-13 (2018)
Abstract Background Vascular supply of tumors is one of the main targets for cancer therapy. Here, we investigated if plocabulin (PM060184), a novel marine-derived microtubule-binding agent, presents antiangiogenic and vascular-disrupting activities.
Externí odkaz:
https://doaj.org/article/4fe7b6e93f754ee2b44db4a385002479
Autor:
Patricia G. Cruz, Carmen Cuevas, Marta Pérez, Juan Fernando Martinez Leal, Antonio Hernández Daranas
Publikováno v:
ACS Omega, Vol 3, Iss 4, Pp 3760-3767 (2018)
ACS Omega
Digital.CSIC. Repositorio Institucional del CSIC
instname
ACS Omega
Digital.CSIC. Repositorio Institucional del CSIC
instname
Two new brominated bis(indole) alkaloids, dragmacidins I (1) and J (2), showing low micromolar cytostatic activity, along with three known congeners were isolated from the Tanzanian sponge Dragmacidon sp. and their structures determined by the analys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34cfc7072cdeea66522ca3fa24986d08
https://doaj.org/article/f5e6874ea6b942efbeb93ed77badcb84
https://doaj.org/article/f5e6874ea6b942efbeb93ed77badcb84
Autor:
Dustin G. Brown, Tove Hultman, Judith Weisz, H. Kim Lyerly, Paola A. Marignani, Ann-Karin Olsen, Rabindra Roy, Kim Moorwood, Masoud H. Manjili, Monica Vaccari, Jesse Roman, Hasiah Ab Hamid, Kalan R. Prudhomme, Periyadan K. Krishnakumar, Chenfang Dong, Tiziana Guarnieri, Leandro S. D'Abronzo, Gloria M. Calaf, Amelia K Charles, Emanuela Corsini, Yunus A. Luqmani, Graeme Williams, Louis Vermeulen, Pankaj Vadgama, Sarah N Bay, Véronique Maguer-Satta, Sabine A. S. Langie, Christian C. Naus, Le Jian, Gladys N. Nangami, Lorenzo Memeo, Stephanie C. Casey, Thomas Sanderson, Takemi Otsuki, Nichola Cruickshanks, William H. Bisson, Sudjit Luanpitpong, Jonathan Whitfield, Ahmed Lasfar, Yon Rojanasakul, A. Ivana Scovassi, Shelley A. Harris, Ferdinando Chiaradonna, Richard Ponce-Cusi, Gregory T. Wolf, Valérian Dormoy, Roslida Abd Hamid, Hyun Ho Park, Matilde E. Lleonart, William K. Decker, Maria Romano, Leroy Lowe, Fabio Marongiu, Jan Vondráček, Chiara Mondello, Luc Leyns, Josiah Ochieng, Pratima Nangia-Makker, Edward A. Ratovitski, Zhiwei Hu, Jayadev Raju, Hemad Yasaei, Rafaela Andrade-Vieira, Jordan Woodrick, Hideko Sone, Harini Krishnan, W. Kimryn Rathmell, Andrew Collins, Luoping Zhang, Barry J. Barclay, Amaya Azqueta, Laura Soucek, Marc A. Williams, David O. Carpenter, Roberta Palorini, Rita Nahta, Juan Fernando Martinez-Leal, Firouz Darroudi, Rita Dornetshuber-Fleiss, James E. Klaunig, Elizabeth P. Ryan, Qiang Shawn Cheng, Arthur Berg, Andrew Ward, Gudrun Koppen, Tao Chen, Petr Heneberg, Michael Gilbertson, Amedeo Amedei, Sakina E. Eltom, Ezio Laconi, Joseph Christopher, Hiroshi Kondoh, Neetu Singh, Danielle J Carlin, Marion Chapellier, Michalis V. Karamouzis, Rekha Mehta, Tae-Jin Lee, Annamaria Colacci, Venkata S. Sabbisetti, Mark Wade, Micheline Kirsch-Volders, Patricia Ostrosky-Wegman, Isabelle R. Miousse, Patricia A. Thompson, Philippa D. Darbre, Frederik J. van Schooten, Sofia Pavanello, Igor Koturbash, Binhua P. Zhou, Ranjeet Kumar Sinha, Anna C. Salzberg, Mahara Valverde, Fahd Al-Mulla, Julia Kravchenko, Nicole Kleinstreuer, Carolyn J. Baglole, Menghang Xia, Samira A. Brooks, Amancio Carnero, Gunnar Brunborg, Sandra S. Wise, Daniel C. Koch, John Pierce Wise, Rabeah Al-Temaimi, Laetitia Gonzalez, Lisa J. McCawley, R. Brooks Robey, Gary S. Goldberg, Thierry Massfelder, Linda S M Gulliver, Olugbemiga Ogunkua, Emilio Rojas, Eun-Yi Moon, Lin Li, Silvana Papagerakis, Nik van Larebeke, Adela Lopez de Cerain Salsamendi, Staffan Eriksson, Simona Romano, Dean W. Felsher, Paramita M. Ghosh, Karine A. Cohen-Solal, Paul Dent, Jun Sun, Carmen Blanco-Aparicio, Riccardo Di Fiore, Chia-Wen Hsu, Mahin Khatami, Kannan Badri Narayanan, Francis Martin, Colleen S. Curran, Dale W. Laird, William H. Goodson, Abdul Manaf Ali, Valerie Odero-Marah, Michael J. Gonzalez, Renza Vento, Liang Tzung Lin, Clement G. Yedjou, Hosni Salem, Hsue-Yin Hsu, Zhenbang Chen, Nuzhat Ahmed, Gerard Wagemaker, Sandra Ryeom, Stefano Forte, Debasish Roy, Nancy B. Kuemmerle, Robert C. Castellino, Po Sing Leung, Wilhelm Engström
Publikováno v:
Carcinogenesis, 36 Suppl 1, S254-S296. Oxford University Press
Carcinogenesis
Carcinogenesis, Oxford University Press (OUP), 2015, 36 (Suppl 1), pp.S254-96. ⟨10.1093/carcin/bgv039⟩
Carcinogenesis, 2015, 36 (Suppl 1), pp.S254-96. ⟨10.1093/carcin/bgv039⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname
Carcinogenesis
Carcinogenesis, Oxford University Press (OUP), 2015, 36 (Suppl 1), pp.S254-96. ⟨10.1093/carcin/bgv039⟩
Carcinogenesis, 2015, 36 (Suppl 1), pp.S254-96. ⟨10.1093/carcin/bgv039⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname
Goodson, William H. et al.
© The Author 2015. Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Can
© The Author 2015. Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5823ab67c1d978d35e01104f2396538
https://doi.org/10.1093/carcin/bgv039
https://doi.org/10.1093/carcin/bgv039
Autor:
Juan A. Bueren-Calabuig, Verónica García-Hernández, María José Guillén-Navarro, Pablo Aviles, Victoria Moneo, Carmen Cuevas, Juan Fernando Martinez Leal, Andrea Negri, Luis F. García-Fernández, Marta Martínez-Diez, Alberto Domingo, Federico Gago, Carlos M. Galmarini
Publikováno v:
British Journal of Pharmacology. 161:1099-1110
BACKGROUND AND PURPOSE PM01183 is a new synthetic tetrahydroisoquinoline alkaloid that is currently in phase I clinical development for the treatment of solid tumours. In this study we have characterized the interactions of PM01183 with selected DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9201271ad37634575c06855022cd7a53
https://doi.org/10.1111/j.1476-5381.2010.00945.x
https://doi.org/10.1111/j.1476-5381.2010.00945.x
Autor:
Matilde E. Lleonart, Dustin G. Brown, Monica Vaccari, Roslida Abd Hamid, Hemad Yasaei, Carmen Blanco-Aparicio, Hosni Salem, Jayadev Raju, Rabindra Roy, Sandra S. Wise, Amedeo Amedei, A. Ivana Scovassi, Jordan Woodrick, Stefano Forte, Neetu Singh, Lorenzo Memeo, Chiara Mondello, Fahd Al-Mulla, Amancio Carnero, Rabeah Al-Temaimi, Hiroshi Kondoh, Annamaria Colacci, John Pierce Wise, Juan Fernando Martinez-Leal, William H. Bisson, Elizabeth P. Ryan
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Carnero, Amancio et al.
© The Author 2015. Carcinogenesis is thought to be a multistep process, with clonal evolution playing a central role in the process. Clonal evolution involves the repeated 'selection and succession' of rare variant cells
© The Author 2015. Carcinogenesis is thought to be a multistep process, with clonal evolution playing a central role in the process. Clonal evolution involves the repeated 'selection and succession' of rare variant cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b328b71258aa983bfa843786b025f67
http://hdl.handle.net/10261/142998
http://hdl.handle.net/10261/142998
Autor:
Amancio Carnero, David D. Beach, S. Rizzo, Juan Fernando Martinez-Leal, Jesús Gil, David Bernard, Gordon Peters, Dolores Martinez, David D. Hudson, Tapio Visakorpi
Publikováno v:
Oncogene. 24:5543-5551
Control of cell proliferation by Polycomb group proteins (PcG) is an important facet of cellular homeostasis and its disruption can promote tumorigenesis. We recently described CBX7 as a novel PcG protein controlling the growth of normal cells. In an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cfe67d322dfa48d74f80bc67a634278
https://doi.org/10.1038/sj.onc.1208735
https://doi.org/10.1038/sj.onc.1208735
Autor:
Moshe Oren, Miri Moas, Tanya M. Gottlieb, Dan Michael, Ruth Maya, Yoichi Taya, Jan Taplick, Avri Ben-Ze'ev, Rony Seger, Alexander Damalas, Juan Fernando Martinez Leal
Publikováno v:
Annals of the New York Academy of Sciences. 973:374-383
The p53 tumor suppressor protein provides a major anti-cancer defense mechanism, as underscored by the fact that the p53 gene is the most frequent target for genetic alterations in human cancer. Recent work has led to the realization that p53 lies at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d5ed13ab702932e599a47e67b0103ce
https://doi.org/10.1111/j.1749-6632.2002.tb04669.x
https://doi.org/10.1111/j.1749-6632.2002.tb04669.x
Autor:
Dan Michael, Yoichi Taya, Alexander Damalas, Jan Taplick, Ruth Maya, Avri Ben-Ze'ev, Moshe Oren, Juan Fernando Martinez Leal, Tanya M. Gottlieb, Rony Seger, Miri Moas
Publikováno v:
Biochemical Pharmacology. 64:865-871
The p53 tumor suppressor protein provides a major anti-cancer defense mechanism, as underscored by the fact that the p53 gene is the most frequent target for genetic alterations in human cancer. Recent work has led to the realization that p53 lies at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b6da9b4a798efe1976077e617bb94e2
https://doi.org/10.1016/s0006-2952(02)01149-8
https://doi.org/10.1016/s0006-2952(02)01149-8
Autor:
Moshe Oren, Inbal Simcha, Juan Fernando Martinez Leal, Jacob Zhurinsky, Benjamin Geiger, Alexander Damalas, Michael Shtutman, Avri Ben-Ze'ev
Publikováno v:
The EMBO Journal. 18:3054-3063
beta-catenin is a multifunctional protein, acting both as a structural component of the cell adhesion machinery and as a transducer of extracellular signals. Deregulated beta-catenin protein expression, due to mutations in the beta-catenin gene itsel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e53222d7e8bf3d26dc9734897c6074d
https://doi.org/10.1093/emboj/18.11.3054
https://doi.org/10.1093/emboj/18.11.3054
Autor:
Victoria Moneo, Alberto Domingo, Carmen Cuevas, María José Guillén-Navarro, Juan Fernando Martinez Leal, Carlos M. Galmarini, Luis F. García-Fernández, Juan A. Bueren-Calabuig, Verónica García-Hernández, Pablo M. Aviles, Federico Gago, Andrea Negri
Publikováno v:
Biochemical pharmacology. 78(2)
Zalypsis® is a new synthetic alkaloid tetrahydroisoquinoline antibiotic that has a reactive carbinolamine group. This functionality can lead to the formation of a covalent bond with the amino group of selected guanines in the DNA double helix, both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f54e0cc8f74c3b6bf92eb8cc3ad94251
https://pubmed.ncbi.nlm.nih.gov/19427997
https://pubmed.ncbi.nlm.nih.gov/19427997