Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Juan Fafián-Labora"'
Autor:
Junquera López-Seijas, Diego Miranda-Balbuena, Alba Iglesias-Fente, Marta Sacristán-Santos, Natalia Carballo-Pedrares, María C. Arufe, Ana Rey-Rico, Juan Fafián-Labora
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 302-317 (2023)
Senescence is a process characterized by a prolonged irreversible cell-cycle arrest. The accumulation of senescent cells in tissues is related to aging and to the development of age-related diseases. Recently, gene therapy has emerged as a powerful t
Externí odkaz:
https://doaj.org/article/b6c4196608cc44c4a45f2d2b4b9cc5e7
Autor:
Juan Fafián-Labora, Miriam Morente-López, María José Sánchez-Dopico, Onno J. Arntz, Fons A. J. van de Loo, Javier De Toro, María C. Arufe
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-12 (2020)
Abstract Introduction This study assessed whether mesenchymal stem cell (MSC)-derived extracellular vesicles influenced ageing and pluripotency markers in cell cultures where they are added. Methods MSC-derived extracellular vesicles from old and you
Externí odkaz:
https://doaj.org/article/39565356b48f49d88502227fa058383f
Study of Ferroptosis Transmission by Small Extracellular Vesicles in Epithelial Ovarian Cancer Cells
Autor:
Carmen Alarcón-Veleiro, Rocío Mato-Basalo, Sergio Lucio-Gallego, Andrea Vidal-Pampín, María Quindós-Varela, Thamer Al-Qatarneh, Germán Berrecoso, Ángel Vizoso-Vázquez, María C. Arufe, Juan Fafián-Labora
Publikováno v:
Antioxidants, Vol 12, Iss 1, p 183 (2023)
Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. The current treatment for EOC involves surgical debulking of the tumors followed by a combination of chemotherapy. While most patients achieve complete remission, many EOCs will
Externí odkaz:
https://doaj.org/article/69f55f7371ba4c22b8a59f19387490fe
Autor:
Michela Borghesan, Juan Fafián-Labora, Olga Eleftheriadou, Paula Carpintero-Fernández, Marta Paez-Ribes, Gema Vizcay-Barrena, Avital Swisa, Dror Kolodkin-Gal, Pilar Ximénez-Embún, Robert Lowe, Belen Martín-Martín, Hector Peinado, Javier Muñoz, Roland A. Fleck, Yuval Dor, Ittai Ben-Porath, Anna Vossenkamper, Daniel Muñoz-Espin, Ana O’Loghlen
Publikováno v:
Cell Reports, Vol 27, Iss 13, Pp 3956-3971.e6 (2019)
Summary: Senescence is a cellular phenotype present in health and disease, characterized by a stable cell-cycle arrest and an inflammatory response called senescence-associated secretory phenotype (SASP). The SASP is important in influencing the beha
Externí odkaz:
https://doaj.org/article/b729ed53c3154141a7268dbbac8c71b2
Autor:
Rocío Mato-Basalo, Miriam Morente-López, Onno J Arntz, Fons A. J. van de Loo, Juan Fafián-Labora, María C. Arufe
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7, p 3367 (2021)
Mesenchymal stem cells have an important potential in the treatment of age-related diseases. In the last years, small extracellular vesicles derived from these stem cells have been proposed as cell-free therapies. Cellular senescence and proinflammat
Externí odkaz:
https://doaj.org/article/9e69c9545c8447e498683ac6ef82eca2
Autor:
Jesús Mateos, Juan Fafián-Labora, Miriam Morente-López, Iván Lesende-Rodriguez, Lorenzo Monserrat, María A Ódena, Eliandre de Oliveira, Javier de Toro, María C Arufe
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205878 (2018)
Hutchinson-Gilford progeria syndrome (HGPS) is a very rare fatal disease characterized for accelerated aging. Although the causal agent, a point mutation in LMNA gene, was identified more than a decade ago, the molecular mechanisms underlying HGPS ar
Externí odkaz:
https://doaj.org/article/20f030c0b4a04c5185b412556ff0e6ea
Autor:
Maribel Marquina, Javier A. Collado, Magdiel Pérez-Cruz, Pablo Fernández-Pernas, Juan Fafián-Labora, Francisco J. Blanco, Rafael Máñez, María C. Arufe, Cristina Costa
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Xenogeneic chondrocytes and allogeneic mesenchymal stem cells (MSC) are considered a potential source of cells for articular cartilage repair. We here assessed the immune response triggered by xenogeneic chondrocytes when injected intraarticularly, a
Externí odkaz:
https://doaj.org/article/031b0eb1d96c4e9eb681f6d388aa2bc8
Publikováno v:
Frontiers in Molecular Biosciences, Vol 4 (2017)
Extracellular vesicles are a heterogeneous and dynamic group of lipid bilayer membrane nanoparticles that can be classified into three different groups depending on their cellular origin: exosomes, microvesicles, and apoptotic bodies. They are produc
Externí odkaz:
https://doaj.org/article/e6add19e7add484d87703e225e4e875b
Autor:
Ana O'Loghlen, Juan Fafián-Labora
Publikováno v:
RUC. Repositorio da Universidade da Coruña
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[Abstract] Intercellular communication refers to the different ways through which cells communicate with each other and transfer a variety of messages. These communication methods involve a number of different processes that occur individually or sim
Autor:
Michela Borghesan, Ana O'Loghlen, O Eleftheriadou, T Mitchell, Juan Fafián-Labora, Thomas D. Nightingale, Paula Carpintero-Fernández, Maria D. Mayan
SUMMARYDuring this last decade the development of pro-senescence therapies has become an attractive strategy as cellular senescence acts as a barrier against tumour progression. In this context, CDK4/6 inhibitors induce senescence and have showed eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c2b10ba6b9c00bf020f6e1db0bd764d
https://doi.org/10.1101/2021.11.30.470520
https://doi.org/10.1101/2021.11.30.470520