Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Juan F. Rodriguez Alcazar"'
Autor:
Brendon D. Parsons, Daniel Medina-Luna, Michal Scur, Marinella Pinelli, Gayani S. Gamage, Rebecca A. Chilvers, Yannick Hamon, Ibrahim H.I. Ahmed, Stéphane Savary, Andrew P. Makrigiannis, Nancy E. Braverman, Juan F. Rodriguez-Alcazar, Eicke Latz, Tobias K. Karakach, Francesca Di Cara
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113744- (2024)
Summary: Peroxisome biogenesis disorders (PBDs) represent a group of metabolic conditions that cause severe developmental defects. Peroxisomes are essential metabolic organelles, present in virtually every eukaryotic cell and mediating key processes
Externí odkaz:
https://doaj.org/article/a066126b3d614f75b0ca3c0d6ec4d610
Autor:
Florian Hoss, James L. Mueller, Francisca Rojas Ringeling, Juan F. Rodriguez-Alcazar, Rebecca Brinkschulte, Gerald Seifert, Rainer Stahl, Lori Broderick, Chris D. Putnam, Richard D. Kolodner, Stefan Canzar, Matthias Geyer, Hal M. Hoffman, Eicke Latz
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Leucine-rich repeat (LRR) domains are commonly present in immune regulatory proteins. Here the authors show that LRR exonic modularity and alternative splicing of an LRR-containing protein, NLRP3, modulate the ratio of functional/afunctional NLRP3 is
Externí odkaz:
https://doaj.org/article/e8556fbf0c984427a366f6b71e4114ec
Autor:
Inga V. Hochheiser, Heide Behrmann, Matthias Geyer, Gregor Hagelueken, Eicke Latz, Anja Kopp, Elmar Behrmann, Juan F. Rodriguez-Alcazar
Publikováno v:
Science advances. 8(19)
SUMMARYInflammasomes sense intrinsic and extrinsic danger signals to trigger inflammatory responses and pyroptotic cell death. Homotypic pyrin domain (PYD) interactions of inflammasome forming Nod-like receptors with the adaptor protein ASC mediate o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c4c7e177b1c1bec520da25d0246c08d
https://pubmed.ncbi.nlm.nih.gov/35559676
https://pubmed.ncbi.nlm.nih.gov/35559676
Autor:
Roisin McManus, Max P. Komes, Angelika Griep, Francesco Santarelli, Stephanie Schwartz, Juan Ramon Perea, Michelle-Amirah Khalil, Mario Lauterbach, Lea Heinemann, Titus Schlüter, Juan F. Rodriguez Alcazar, Susanne F. Schmidt, Jasper Spitzer, Peri Noori, Alberto Maillo, David Gomez-Cabrero, Jesper Tegnér, Karsten Hiller, Eicke Latz, Michael T. Heneka
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a253573ae0c6aede58a4840d859c449
https://doi.org/10.2139/ssrn.4178538
https://doi.org/10.2139/ssrn.4178538
Autor:
Bernardo S. Franklin, Christine Schmitt-Mabmunyo, Marco A. Ataide, Wolfgang Kastenmüller, Gudrun Engels, Juan F. Rodriguez-Alcazar, Natalio Garbi, Eicke Latz
Publikováno v:
The journal of immunology 202(2), 550-558 (2018). doi:10.4049/jimmunol.1800107
Charcot–Leyden crystals (CLCs) are Galectin-10 protein crystals that can form after eosinophils degranulate. CLCs can appear and persist in tissues from patients with eosinophilic disorders, such as asthma, allergic reactions, and fungal and helmin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26ddb9d40b91187427c65411993cfeab
https://doi.org/10.4049/jimmunol.1800107
https://doi.org/10.4049/jimmunol.1800107
Autor:
Gerald Seifert, Florian Hoss, Stefan Canzar, Juan F. Rodriguez-Alcazar, Matthias Geyer, Francisca Rojas Ringeling, Hal M. Hoffman, Rainer Stahl, Christopher D. Putnam, James L. Mueller, Lori Broderick, Eicke Latz, Richard D. Kolodner, Rebecca Brinkschulte
Publikováno v:
Nature Communications 10(1), 3238 (2019). doi:10.1038/s41467-019-11076-1
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature communications, vol 10, iss 1
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature communications, vol 10, iss 1
Leucine-rich repeat (LRR) domains are evolutionarily conserved in proteins that function in development and immunity. Here we report strict exonic modularity of LRR domains of several human gene families, which is a precondition for alternative splic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7956af9e03ff5838d792045b0e2b2f9f
Publikováno v:
Cellular and molecular life sciences 74(7), 1211-1229 (2016). doi:10.1007/s00018-016-2396-6
The inflammasome adapter ASC links activated inflammasome sensors to the effector molecule pro-caspase-1. Recruitment of pro-caspase-1 to ASC promotes the autocatalytic activation of caspase-1, which leads to the release of pro-inflammatory cytokines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::003ddcb053708f149370c316c6eaf07d
https://pubmed.ncbi.nlm.nih.gov/27761594
https://pubmed.ncbi.nlm.nih.gov/27761594