Zobrazeno 1 - 10 of 57 pro vyhledávání: '"Juan F. Espinosa"'
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Akademický článek
Activation of the human insulin receptor by non-insulin-related peptides
Autor: Nicholas S. Kirk, Qi Chen, Yingzhe Ginger Wu, Anastasia L. Asante, Haitao Hu, Juan F. Espinosa, Francisco Martínez-Olid, Mai B. Margetts, Faiz A. Mohammed, Vladislav V. Kiselyov, David G. Barrett, Michael C. Lawrence
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The regulation of plasma glucose levels is effected by insulin. Here, the authors reveal atomic detail of how peptides distinct from insulin bind to and activate the insulin receptor, with implications for design of small-molecule insulin mimetics.
Externí odkaz: https://doaj.org/article/1dab09f8cbff49e29577a56810f3b259
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3
Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences
Autor: José Francisco Soriano, Javier Agejas, Rosario Gonzalez, Ramón Rodríguez, Timothy B. Durham, Howard Barff Broughton, Juan F. Espinosa, Paloma Vidal, Ana B. Bueno, Robert Dean Dally, Hsiu-Chiung Yang, Alicia Marcos, David E. Timm, Gema Sanz, James R. McCarthy, Patric James Hahn
Publikováno v: Journal of Medicinal Chemistry. 60:9807-9820
NMR conformational analysis of a hydroxyethylamine peptide isostere developed as an aspartic protease inhibitor shows that it is a flexible architecture. Cyclization to form pyrrolidines, piperidines, or morpholines results in a preorganization of th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c3ae5f96ab4869e6ec456bade5b1dc
https://doi.org/10.1021/acs.jmedchem.7b01304
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5
Protein-Observed Fluorine NMR Is a Complementary Ligand Discovery Method to 1H CPMG Ligand-Observed NMR
Autor: William C. K. Pomerantz, Haitao Hu, Luis Pablo Calle, Juan F. Espinosa, Andrew K. Urick
Publikováno v: ACS Chem Biol
To evaluate its potential as a ligand discovery tool, we compare a newly developed 1D protein-observed fluorine NMR (PrOF NMR) screening method with the well-characterized ligand-observed (1)H CPMG NMR screen. We selected the first bromodomain of Brd
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa11549cb0bbc6583fec694cb78a2a4e
https://doi.org/10.1021/acschembio.6b00730
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6
Two-Site Evaluation of the Repeatability and Precision of an Automated Dual-Column Hydrogen/Deuterium Exchange Mass Spectrometry Platform
Autor: Manuel Molina-Martin, Juan F. Espinosa, Patrick R. Griffin, David J. Cummins, Alfonso Espada, Devrishi Goswami, Howard B. Broughton, Ryan Edward Stites, Bruce D. Pascal, Michael J. Chalmers, Jeffrey Alan Dodge, Scott J. Novick
Publikováno v: Analytical Chemistry. 88:6607-6614
Hydrogen/deuterium exchange coupled with mass spectrometry (HDX-MS) is an information-rich biophysical method for the characterization of protein dynamics. Successful applications of differential HDX-MS include the characterization of protein-ligand
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f4811489bad786b8766bf5b85c872c
https://doi.org/10.1021/acs.analchem.6b01650
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7
The L-type voltage-gated calcium channel modulates microglial pro-inflammatory activity
Autor: Juan F. Espinosa-Parrilla, M. Martínez-Moreno, Nicole Mahy, Manuel J. Rodriguez, Xavier Gasull
Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Under pathological conditions, microglia, the resident CNS immune cells, become reactive and release pro-inflammatory cytokines and neurotoxic factors. We investigated whether this phenotypic switch includes changes in the expression of the L-type vo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::700f81b42e2a98964a465444f7b5c1c9
https://doi.org/10.1016/j.mcn.2014.12.004
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9
Effects of Low Phytanic Acid-Concentrated DHA on Activated Microglial Cells: Comparison with a Standard Phytanic Acid-Concentrated DHA
Autor: Juan F. Espinosa-Parrilla, Sandra Ballesteros, Beatriz Martín-Fernández, María Belén Ruiz-Roso, Baltasar Ruiz-Roso, Natalia de las Heras, Vicente Lahera, José Carlos Quintela, Elena Olivares-Álvaro
Publikováno v: Neuromolecular medicine. 20(3)
Docosahexaenoic acid (DHA, 22:6 n-3) is an essential omega-3 (ω-3) long chain polyunsaturated fatty acid of neuronal membranes involved in normal growth, development, and function. DHA has been proposed to reduce deleterious effects in neurodegenera
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a1940c4cc3380487c1c6c431b109be
https://pubmed.ncbi.nlm.nih.gov/29846873
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10
Natural Docosahexaenoic Acid in the Triglyceride Form Attenuates In Vitro Microglial Activation and Ameliorates Autoimmune Encephalomyelitis in Mice
Autor: Joan Carles Domingo, Pilar Mancera, Marco Pugliese, Juan F. Espinosa-Parrilla, Blanca Wappenhans, Noemí Virgili, Felix Rueda, Begoña Cordobilla
Publikováno v: Nutrients, Vol 9, Iss 7, p 681 (2017)
Nutrients; Volume 9; Issue 7; Pages: 681
Recercat. Dipósit de la Recerca de Catalunya
instname
Nutrients
Dipòsit Digital de la UB
Universidad de Barcelona
Many neurodegenerative diseases are associated, at least in part, to an inflammatory process in which microglia plays a major role. The effect of the triglyceride form of the omega-3 polyunsaturated fatty acid docosahexaenoic acid (TG-DHA) was assaye
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac57ff16dce5f6f05c9785cb7901abf
http://www.mdpi.com/2072-6643/9/7/681
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