Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Juan F Macias-Velasco"'
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-15 (2023)
Abstract Background Understanding how heterogeneous β-cell function impacts diabetes is imperative for therapy development. Standard single-cell RNA sequencing analysis illuminates some factors driving heterogeneity, but new strategies are required
Externí odkaz:
https://doaj.org/article/cb66e9ebff3f4a4795a0f4944d648a14
Autor:
Juan F Macias-Velasco, Celine L St Pierre, Jessica P Wayhart, Li Yin, Larry Spears, Mario A Miranda, Caryn Carson, Katsuhiko Funai, James M Cheverud, Clay F Semenkovich, Heather A Lawson
Publikováno v:
eLife, Vol 11 (2022)
Parent-of-origin effects are unexpectedly common in complex traits, including metabolic and neurological traits. Parent-of-origin effects can be modified by the environment, but the architecture of these gene-by-environmental effects on phenotypes re
Externí odkaz:
https://doaj.org/article/544b0a3b284647ab9a32696c108eb34a
Autor:
Mario A. Miranda, Caryn Carson, Celine L. St. Pierre, Juan F. Macias‐Velasco, Jing W. Hughes, Marcus Kunzmann, Heather Schmidt, Jessica P. Wayhart, Heather A. Lawson
Publikováno v:
Physiological Reports, Vol 8, Iss 20, Pp n/a-n/a (2020)
Abstract Maintenance of functional β‐cell mass is critical to preventing diabetes, but the physiological mechanisms that cause β‐cell populations to thrive or fail in the context of obesity are unknown. High fat‐fed SM/J mice spontaneously tr
Externí odkaz:
https://doaj.org/article/ac1457641c834e28b3bd00915e615bb4
Autor:
Caryn Carson, Juan F. Macias-Velasco, Subhadra Gunawardana, Mario A. Miranda, Sakura Oyama, Celine L. St. Pierre, Heather Schmidt, Jessica P. Wayhart, Heather A. Lawson
Publikováno v:
Cell Reports, Vol 33, Iss 1, Pp 108237- (2020)
Summary: We leverage the SM/J mouse to understand glycemic control in obesity. High-fat-fed SM/J mice initially develop poor glucose homeostasis relative to controls. Strikingly, their glycemic dysfunction resolves by 30 weeks of age despite persiste
Externí odkaz:
https://doaj.org/article/a6b2ac652f3f4af58c41b82a97fc3808
Background Understanding how heterogeneous β-cell function impacts diabetes is imperative for therapy development. Standard single-cell RNA sequencing analysis illuminates some factors driving heterogeneity, but new strategies are required to enhanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed5412dab2d238b7acd86d962041921b
https://doi.org/10.21203/rs.3.rs-1689634/v1
https://doi.org/10.21203/rs.3.rs-1689634/v1
Autor:
Juan F Macias-Velasco, Celine L St Pierre, Jessica P Wayhart, Li Yin, Larry Spears, Mario A Miranda, Caryn Carson, Katsuhiko Funai, James M Cheverud, Clay F Semenkovich, Heather A Lawson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c73ab05d13a5b03bea95a37b81c63c59
https://doi.org/10.7554/elife.72989.sa2
https://doi.org/10.7554/elife.72989.sa2
Autor:
Celine L. St. Pierre, Juan F. Macias-Velasco, Jessica P. Wayhart, Li Yin, Clay F. Semenkovich, Heather A. Lawson
Publikováno v:
Genome research. 32(6)
Allele-specific expression (ASE) is a phenomenon in which one allele is preferentially expressed over the other. Genetic and epigenetic factors cause ASE by altering the final composition of a gene's product, leading to expression imbalances that can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::535e22edbcca9d0ce8cc4487c3ead424
https://pubmed.ncbi.nlm.nih.gov/35501130
https://pubmed.ncbi.nlm.nih.gov/35501130
Autor:
Juan F Macias-Velasco, Celine L. St. Pierre, Li Yin, James M. Cheverud, Larry D. Spears, Jessica P Wayhart, Katsuhiko Funai, Mario A. Miranda, Heather A. Lawson, Clay F. Semenkovich, Caryn Carson
Publikováno v:
eLife. 11
Parent-of-origin effects are unexpectedly common in complex traits, including metabolic and neurological diseases. Parent-of-origin effects can be modified by the environment, but the architecture of these gene-by-environmental effects on phenotypes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d6d00393c87a91d0fbe9eec491d70f
https://pubmed.ncbi.nlm.nih.gov/35356864
https://pubmed.ncbi.nlm.nih.gov/35356864
Understanding how heterogeneous β-cell function and stress response impact diabetic etiology is imperative for therapy development. Standard single-cell RNA sequencing analysis illuminates some genetic underpinnings driving heterogeneity, but new st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11d89723b7c4643c9b7f5d7e0d6afacc
https://doi.org/10.1101/2021.07.15.452524
https://doi.org/10.1101/2021.07.15.452524
Publikováno v:
Am J Physiol Endocrinol Metab
Pancreatic β-cells perform glucose-stimulated insulin secretion, a process at the center of type 2 diabetes etiology. Efforts to understand how β-cells behave in healthy and stressful conditions have revealed a wide degree of morphological, functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f651c30d0b77b93c4e849f5abf2a9f
https://europepmc.org/articles/PMC8238131/
https://europepmc.org/articles/PMC8238131/