Evaluating the pharmacological response in fluorescence microscopy images: The Δm algorithm.

Autor: Ana I Gómez, Marcos Cruz, Juan F López-Giménez

Publikováno v: PLoS ONE, Vol 14, Iss 2, p e0211330 (2019)

Current drug discovery procedures require fast and effective quantification of the pharmacological response evoked in living cells by agonist compounds. In the case of G-protein coupled receptors (GPCRs), the efficacy of a particular drug to initiate

Externí odkaz: https://doaj.org/article/8e07e5317573416eb87a1d8912dbe70b

His452Tyr polymorphism in the human 5-HT

Autor: Sandra M, Martín-Guerrero, Paula, Alonso, Alba, Iglesias, Marta, Cimadevila, José, Brea, M Isabel, Loza, Pedro, Casado, David, Martín-Oliva, Pedro R, Cutillas, Javier, González-Maeso, Juan F, López-Giménez

Publikováno v: Biochemical pharmacology. 185

Antipsychotic drugs remain the current standard for schizophrenia treatment. Although they directly recognize the orthosteric binding site of numerous monoaminergic G protein-coupled receptors (GPCRs), these drugs, and particularly second-generation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::47615c4d65f009315f179da2f7d2a5e4
https://pubmed.ncbi.nlm.nih.gov/33539816

Interclass GPCR heteromerization affects localization and trafficking

Autor: Stuart C. Sealfon, Urjita H. Shah, Rudy Toneatti, Miguel Fribourg, Paul T. Arsenovic, Juan F. López-Giménez, Justin M. Saunders, Daniel E. Conway, Jong M. Shin, Deanna L. Benson, William G.M. Janssen, Javier González-Maeso, Carl R. Mayer

Publikováno v: Sci Signal
Digital.CSIC. Repositorio Institucional del CSIC
instname

Membrane trafficking processes regulate G protein-coupled receptor (GPCR) activity. Although class A GPCRs are capable of activating G proteins in a monomeric form, they can also potentially assemble into functional GPCR heteromers. Here, we showed t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f42f6eacb2223840308c63fc49984472
http://hdl.handle.net/10261/227463

Poly(ADP-Ribose) Polymerase-1 inhibition potentiates cell death and phosphorylation of DNA damage response proteins in oxidative stressed retinal cells

Autor: Pedro R. Cutillas, Miguel A. Cuadros, Juan F. López-Giménez, Julio Navascués, David Martín-Oliva, María-Carmen Carrasco, José Antonio Muñoz-Gámez, Pedro Casado, Sandra M. Martín-Guerrero

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Oxidative stress (OxS) is involved in the development of cell injures occurring in retinal diseases while Poly(ADP-ribose) Polymerase-1 (PARP-1) is a key protein involved in the repair of the DNA damage caused by OxS. Inhibition of PARP-1 activity wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b707e4d35c4a6b1fcd0dec1ec6774759
http://hdl.handle.net/10261/213615

Dopaminergic control of ADAMTS2 expression through cAMP/CREB and ERK: molecular effects of antipsychotics

Autor: Juan F. López-Giménez, Javier González-Maeso, Fuencisla Pilar-Cuéllar, María Juncal-Ruiz, Fulgencio Ruso-Julve, J Javier Meana, Federico Mayor, Rosa Ayesa-Arriola, Benedicto Crespo-Facorro, Salvador Martinez, Raquel Garcia-Lopez, Agustín García-Blanco, José P. Vaqué, Alicia Estirado, Javier Vázquez-Bourgon, Elena Castro, Elsa M. Valdizán, Ana Pombero, Helena Pisonero, Álvaro Díaz, Emilio Garro-Martínez, Nuria García-Díaz

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Addi. Archivo Digital para la Docencia y la Investigación
Transl Psychiatry. 2019 Nov 18;9(1):306
Translational Psychiatry
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
Translational Psychiatry, Vol 9, Iss 1, Pp 1-12 (2019)
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)

© The Author(s) 2019.
A better understanding of the molecular mechanisms that participate in the development and clinical manifestations of schizophrenia can lead to improve our ability to diagnose and treat this disease. Previous data strongly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5816c247af99bd4fbe94c32d144a6825
http://hdl.handle.net/10261/204407