Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Juan F Aranda"'
Autor:
María Mittelbrunn, Elisa Carrasco, Juan F. Aranda, Enrique Gabandé-Rodríguez, Gabriela Desdín-Micó, Manuel M. Gómez de las Heras
Publikováno v:
Nature Reviews Immunology
Age-related T cell dysfunction can lead to failure of immune tolerance mechanisms, resulting in aberrant T cell-driven cytokine and cytotoxic responses that ultimately cause tissue damage. In this Review, we discuss the role of T cells in the onset a
Autor:
Julia Derk, Richard A. Friedman, Carmen Hurtado del Pozo, Meilun He, Ravichandran Ramasamy, Laura Frye, Ann Marie Schmidt, Juan F. Aranda, Hye Lim Noh, Peter Daya, Lakshmi Arivazhagan, Randall H. Friedline, Michael MacLean, Cynthia Shim, Henry H. Ruiz, Jason K. Kim
Publikováno v:
Cell Reports, Vol 28, Iss 3, Pp 773-791.e7 (2019)
Cell reports
Cell reports
SUMMARY Exquisite regulation of energy homeostasis protects from nutrient deprivation but causes metabolic dysfunction upon nutrient excess. In human and murine adipose tissue, the accumulation of ligands of the receptor for advanced glycation end pr
Autor:
Marta Dueñas, Mirentxu Santos, Juan F Aranda, Concha Bielza, Ana B Martínez-Cruz, Corina Lorz, Miquel Taron, Eva M Ciruelos, José L Rodríguez-Peralto, Miguel Martín, Pedro Larrañaga, Jubrail Dahabreh, George P Stathopoulos, Rafael Rosell, Jesús M Paramio, Ramón García-Escudero
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42494 (2012)
Mutations in the TP53 gene are very common in human cancers, and are associated with poor clinical outcome. Transgenic mouse models lacking the Trp53 gene or that express mutant Trp53 transgenes produce tumours with malignant features in many organs.
Externí odkaz:
https://doaj.org/article/aa4b88e29f75412e9bf812a4c6c27a2d
Autor:
Devi Thiagarajan, Nosirudeen Quadri, Lingjie Wang, Radha Ananthakrishnan, Ravichandran Ramasamy, Juan F. Aranda, Arthur S. Alberts, Gopalkrishna Sreejit, Qing Li, Karen M. O'Shea, Ann Marie Schmidt, Hylde Zirpoli
Publikováno v:
EBioMedicine, Vol 26, Iss C, Pp 165-174 (2017)
EBioMedicine
EBioMedicine
The biochemical, ionic, and signaling changes that occur within cardiomyocytes subjected to ischemia are exacerbated by reperfusion; however, the precise mechanisms mediating myocardial ischemia/reperfusion (I/R) injury have not been fully elucidated
Autor:
Carlos Fernández-Hernando, Cedric Langhi, Leigh Goedeke, Cristina M. Ramírez, Ángel Baldán, Juan F. Aranda, Yajaira Suárez, Ana Fernández-Hernando, Rafael de Cabo, Alberto Canfrán-Duque, Elisa Araldi, Noemi Rotllan
Publikováno v:
Atherosclerosis. 243:499-509
Recently, there has been significant interest in the therapeutic administration of miRNA mimics and inhibitors to treat cardiovascular disease. In particular, miR-27b has emerged as a regulatory hub in cholesterol and lipid metabolism and potential t
Autor:
Leigh Goedeke, Miguel A. Lasunción, Alberto Canfrán-Duque, Norma N. Anderson, Noemi Rotllan, Anders M. Näär, Alexandre Wagschal, Jay D. Horton, Elisa Araldi, Juan F. Aranda, Yajaira Suárez, Cristina M. Ramírez, Carlos Fernández-Hernando, Rafael de Cabo, Chin Sheng Lin
Publikováno v:
Nature Medicine. 21:1280-1289
The hepatic low-density lipoprotein receptor (LDLR) pathway is essential for clearing circulating LDL cholesterol (LDL-C). Whereas the transcriptional regulation of LDLR is well characterized, the post-transcriptional mechanisms that govern LDLR expr
Retrograde transport (RT) allows cells to retrieve receptors and other cellular cargoes for delivery to the Golgi apparatus, contributing to the maintenance of cellular homeostasis. This transport route is also commonly used by several bacterial toxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39043c0963b74dc4dc6ea0e8c3e53303
https://europepmc.org/articles/PMC5954181/
https://europepmc.org/articles/PMC5954181/
Autor:
Alberto Dávalos, Javier Martínez-Botas, Valentini Konstantinidou, Mercedes Klett-Mingo, Juan F. Aranda, Carlos Fernández-Hernando, Lidia Daimiel-Ruiz, Víctor Micó, Belén García, Jose M. Ordovas
Publikováno v:
Molecular Nutrition & Food Research. 59:1865-1878
Scope The increased prevalence of cardiovascular diseases (CVDs) has been hypothesized to be the result of an increased exposure to a host of atherogenic environmental factors, paramount among them being unhealthy dietary habits. Long-chain n-3 polyu
Publikováno v:
Current Opinion in Lipidology. 25:282-288
PURPOSE OF REVIEW The objective of this review article is to summarize the recent findings about the importance of microRNAs (miRNAs) in regulating lipoprotein metabolism. We highlight the recent findings that uncover the importance of miRNAs in cont
Autor:
Maria I. Garín, Carmen Segrelles, Juan F. Aranda, Mirentxu Santos, Corina Lorz, José M. Ariza, Ramón García-Escudero, Pilar Hernández, Jesús M. Paramio
Publikováno v:
Stem Cells. 32:1917-1928
Hair follicle stem cells (HF-SCs) alternate between periods of quiescence and proliferation, to finally differentiate into all the cell types that constitute the hair follicle. Also, they have been recently identified as cells of origin in skin cance