Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Juan Félix Espinosa"'
Publikováno v:
Biophysical Techniques in Drug Discovery ISBN: 9781782627333
This book chapter describes the basic principles of NMR-based techniques for detecting ligand binding and uses examples of the application of these techniques in drug discovery programs for screening, hit validation and optimization to illustrate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::503f17bd30fb3a565f57c1db6c6397a9
https://doi.org/10.1039/9781788010016-00023
https://doi.org/10.1039/9781788010016-00023
Publikováno v:
Magnetic resonance in chemistry : MRC. 55(4)
Autor:
Juan Félix Espinosa, Ivan Collado, Darryle Darwin Schoepp, Ann E. Kingston, Bryan G. Johnson, Angel Mazon, Concepcion Pedregal, Jaime Blanco-Urgoiti, Rebecca A. Wright
Publikováno v:
Journal of Medicinal Chemistry. 45:3619-3629
The asymmetric synthesis and biological activity of (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine 7 and its epimer at the C3' center 6 are described. Compound 7 is a highly potent and selective agonist for group 2 metabotropric glutama
Autor:
Jesús Jiménez-Barbero, Lore Brade, Thomas Haselhorst, Tobias Sokolowski, Juan-Félix Espinosa, Thomas Peters, Helmut Brade, Paul Kosma
Publikováno v:
Biochemistry. 38:6449-6459
The recognition reactions between a synthetic disaccharide alpha-Kdo-(2-->4)-alpha-Kdo-(2-->O)-allyl and two monoclonal antibodies (mAbs) were studied by NMR, yielding two distinct bound conformations of the carbohydrate ligand. One mAb, S23-24, reco
Autor:
Juan-Félix Espinosa, Olivier Jarreton, Marta Bruix, Jean-Marie Beau, Jesús Jiménez-Barbero, Troels Skrydstrup
Publikováno v:
Chemistry - A European Journal. 5:442-448
Autor:
Jesús Jiménez-Barbero, Olivier Jarreton, Juan-Félix Espinosa, Troels Skrydstrup, Jean-Marie Beau
Publikováno v:
Chemistry - A European Journal. 5:430-441
The mannosyl pyridylsulfone 1 undergoes a remarkably efficient coupling reaction with the 2-deoxy-C2-formyl glycoside 2 in the presence of samarium diiodide to provide the corresponding C-disaccharide in high yield. This represents the first step in
Autor:
Jesús Jiménez-Barbero, A. Vian, A. Imberty, E. Montero, Manuel Martín-Lomas, † Juan-Félix Espinosa, J. L. Garcia, Hansjörg Dietrich, Richard R. Schmidt, F. J. Canada
Publikováno v:
Journal of the American Chemical Society. 120:1309-1318
The enzyme-bound conformation of C-lactose, an Escherichia coli β-galactosidase inhibitor has been determined by NMR spectroscopy. It is demonstrated that the enzyme selects a high-energy conformat...
Autor:
Misericordia Fernández-Saiz, Yi Yi Zhong, Antonio Lorente, Jean-Marie Lehn, W. David Wilson, Juan Félix Espinosa
Publikováno v:
Tetrahedron Letters. 37:4417-4420
As a result of efforts to mimic the activity of RNase A we report the syntheses of two novel molecules 1 and 2 containing imidazole residues conjugated to an acridine, a well known intercalator and as such these molecules simultaneously have substrat
Autor:
Juan-Félix Espinosa, Manuel Martín-Lomas, Richard R. Schmidt, F. Javier Cañada, Jesús Jiménez-Barbero, Hansjörg Dietrich, Juan Luis Asensio
Publikováno v:
Angewandte Chemie International Edition in English. 35:303-306
Autor:
Juan-Félix Espinosa, Jesús Jiménez-Barbero, Manuel Martín-Lomas, F. Javier Cañada, Hansjörg Dietrich, Richard R. Schmidt, Juan Luis Asensio
Publikováno v:
Angewandte Chemie. 108:323-326