Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Juan F, Quintana"'
Autor:
Matthew C. Sinton, Praveena R. G. Chandrasegaran, Paul Capewell, Anneli Cooper, Alex Girard, John Ogunsola, Georgia Perona-Wright, Dieudonné M Ngoyi, Nono Kuispond, Bruno Bucheton, Mamadou Camara, Shingo Kajimura, Cécile Bénézech, Neil A. Mabbott, Annette MacLeod, Juan F. Quintana
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract In the skin, Trypanosoma brucei colonises the subcutaneous white adipose tissue, and is proposed to be competent for forward transmission. The interaction between parasites, adipose tissue, and the local immune system is likely to drive the
Externí odkaz:
https://doaj.org/article/34a1cb8324534887a960552c5aa36b6f
Autor:
Juan F. Quintana, Matthew C. Sinton, Praveena Chandrasegaran, Agatha Nabilla Lestari, Rhiannon Heslop, Bachar Cheaib, John Ogunsola, Dieudonne Mumba Ngoyi, Nono-Raymond Kuispond Swar, Anneli Cooper, Neil A. Mabbott, Seth B. Coffelt, Annette MacLeod
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract African trypanosomes colonise the skin to ensure parasite transmission. However, how the skin responds to trypanosome infection remains unresolved. Here, we investigate the local immune response of the skin in a murine model of infection usi
Externí odkaz:
https://doaj.org/article/9a96c210c22f4f58b0bd9fc2f4ee75ce
Autor:
Juan F Quintana, Matthew C Sinton, Praveena Chandrasegaran, Lalit Kumar Dubey, John Ogunsola, Moumen Al Samman, Michael Haley, Gail McConnell, Nono-Raymond Kuispond Swar, Dieudonné Mumba Ngoyi, David Bending, Luis de Lecea, Annette MacLeod, Neil A Mabbott
Publikováno v:
PLoS Biology, Vol 21, Iss 11, p e3002389 (2023)
The meningeal space is a critical brain structure providing immunosurveillance for the central nervous system (CNS), but the impact of infections on the meningeal immune landscape is far from being fully understood. The extracellular protozoan parasi
Externí odkaz:
https://doaj.org/article/253eccf81f604fb09b7c9c3cff71ce65
Autor:
Juan F. Quintana, Praveena Chandrasegaran, Matthew C. Sinton, Emma M. Briggs, Thomas D. Otto, Rhiannon Heslop, Calum Bentley-Abbot, Colin Loney, Luis de Lecea, Neil A. Mabbott, Annette MacLeod
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Detailed insight into how the brain responds to Trypanosoma brucei infection is lacking. Here, single cell and spatial transcriptomics are integrated to characterise this response, identifying a unique crosstalk between microglia and plasma cells.
Externí odkaz:
https://doaj.org/article/20ce49abd0174cbcba8717412cc4cc41
Autor:
Juan F. Quintana, Matthew C. Sinton, Jay Gopalakrishnan, Praveena Chandrasegaran, Agatha Nabilla Lestari
Publikováno v:
F1000Research, Vol 12 (2023)
Background: Sleeping sickness is caused by the extracellular parasite Trypanosoma brucei and is associated with neuroinflammation and neuropsychiatric disorders, including disruption of sleep/wake patterns, and is now recognised as a circadian disord
Externí odkaz:
https://doaj.org/article/dd3e821bfb2741bd9dca8425a92729dd
Autor:
Matthew C. Sinton, Praveena R. G. Chandrasegaran, Paul Capewell, Anneli Cooper, Alex Girard, John Ogunsola, Georgia Perona-Wright, Dieudonné M Ngoyi, Nono Kuispond, Bruno Bucheton, Mamadou Camara, Shingo Kajimura, Cécile Bénézech, Neil A. Mabbott, Annette MacLeod, Juan F. Quintana
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/51277c3f39fe43e394b3a5b030e6202a
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Externí odkaz:
https://doaj.org/article/32505cf251c3465889783d0151db9870
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104797- (2022)
Summary: Rapid imaging of large biological tissue specimens such as ultrathick sections of mouse brain cannot easily be performed with a standard microscope. Optical mesoscopy offers a solution, but thus far imaging has been too slow to be useful for
Externí odkaz:
https://doaj.org/article/cf0d7b5a78b34c8da92a3d10084e2d9c
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Human African Trypanosomiasis (HAT) is a disease caused by the extracellular parasite Trypanosoma brucei that affects the central nervous system (CNS) during the chronic stage of the infection, inducing neuroinflammation, coma, and death if left untr
Externí odkaz:
https://doaj.org/article/52a28ba5debd41e696d15b4ba0d43f69
Autor:
Alexandre Girard, Anneli Cooper, Samuel Mabbott, Barbara Bradley, Steven Asiala, Lauren Jamieson, Caroline Clucas, Paul Capewell, Francesco Marchesi, Matthew P Gibbins, Franziska Hentzschel, Matthias Marti, Juan F Quintana, Paul Garside, Karen Faulds, Annette MacLeod, Duncan Graham
Publikováno v:
PLoS Pathogens, Vol 17, Iss 11, p e1010060 (2021)
Human African Trypanosomiasis (HAT) has been responsible for several deadly epidemics throughout the 20th century, but a renewed commitment to disease control has significantly reduced new cases and motivated a target for the elimination of Trypanoso
Externí odkaz:
https://doaj.org/article/77d6c85f7c8a4ff8b7be5e61060b8aa3