Structural model for differential cap maturation at growing microtubule ends

Autor: Juan Estévez-Gallego, Fernando Josa-Prado, Siou Ku, Ruben M Buey, Francisco A Balaguer, Andrea E Prota, Daniel Lucena-Agell, Christina Kamma-Lorger, Toshiki Yagi, Hiroyuki Iwamoto, Laurence Duchesne, Isabel Barasoain, Michel O Steinmetz, Denis Chrétien, Shinji Kamimura, J Fernando Díaz, Maria A Oliva

Publikováno v: eLife, Vol 9 (2020)

Microtubules (MTs) are hollow cylinders made of tubulin, a GTPase responsible for essential functions during cell growth and division, and thus, key target for anti-tumor drugs. In MTs, GTP hydrolysis triggers structural changes in the lattice, which

Externí odkaz: https://doaj.org/article/eb49d1e2fe6445b783e2a3c85b0c7bbb

Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands

Autor: Francisco de Asís Balaguer, Tobias Mühlethaler, Juan Estévez-Gallego, Enrique Calvo, Juan Francisco Giménez-Abián, April L. Risinger, Erik J. Sorensen, Christopher D. Vanderwal, Karl-Heinz Altmann, Susan L. Mooberry, Michel O. Steinmetz, María Ángela Oliva, Andrea E. Prota, J. Fernando Díaz

Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 6, p 1392 (2019)

It has been proposed that one of the mechanisms of taxane-site ligand-mediated tubulin activation is modulation of the structure of a switch element (the M-loop) from a disordered form in dimeric tubulin to a folded helical structure in microtubules.

Externí odkaz: https://doaj.org/article/abae6ee18f044a3685a5886a0f71911a

Diphenyl ether derivatives occupy the expanded binding site of cyclohexanedione compounds at the colchicine site in tubulin by movement of the αT5 loop

Autor: Sandra Liekens, Solange Martins, María-José Camarasa, Marta Gargantilla, Juan Estévez-Gallego, Oskía Bueno, María-Jesús Pérez-Pérez, J. Fernando Díaz, Eva-María Priego

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Microtubule targeting agents represent a very active arena in the development of anticancer agents. In particular, compounds binding at the colchicine site in tubulin are being deeply studied, and the structural information recently available on this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e272fdcdac1046df0736414443138ee1
https://doi.org/10.1016/j.ejmech.2019.03.045

Structural model for differential cap maturation at growing microtubule ends

Autor: Isabel Barasoain, Andrea E. Prota, J. Fernando Díaz, Francisco de Asís Balaguer, Christina Kamma-Lorger, Siou Ku, María A. Oliva, Rubén M. Buey, Toshiki Yagi, Laurence Duchesne, Denis Chrétien, Daniel Lucena-Agell, Shinji Kamimura, Juan Estévez-Gallego, Michel O. Steinmetz, Hiroyuki Iwamoto, Fernando Josa-Prado

Publikováno v: eLife
eLife, eLife Sciences Publication, 2020, 9, pp.e50155. ⟨10.7554/eLife.50155⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname
'eLife ', vol: 9, pages: e50155-1-e50155-26 (2020)
eLife, Vol 9 (2020)
eLife, 2020, 9, pp.e50155. ⟨10.7554/eLife.50155⟩

26 p.-5 fig.-5 tab.
Microtubules (MTs) are hollow cylinders made of tubulin, a GTPase responsible for essential functions during cell growth and division, and thus, key target for anti-tumor drugs. In MTs, GTP hydrolysis triggers structural chan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77f00c01fd31baf004ef430cbc4a55d6
https://hal.archives-ouvertes.fr/hal-02552246/file/hal-02552246.pdf

Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands

Autor: María A. Oliva, Karl-Heinz Altmann, Erik J. Sorensen, Juan Estévez-Gallego, Andrea E. Prota, Juan F. Giménez-Abián, J. Fernando Díaz, April L. Risinger, Michel O. Steinmetz, Christopher D. Vanderwal, Tobias Mühlethaler, Enrique Calvo, Francisco de Asís Balaguer, Susan L. Mooberry

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
International Journal of Molecular Sciences, 20 (6)
International Journal of Molecular Sciences
Volume 20
Issue 6
Repisalud
Instituto de Salud Carlos III (ISCIII)
International Journal of Molecular Sciences, Vol 20, Iss 6, p 1392 (2019)

It has been proposed that one of the mechanisms of taxane-site ligand-mediated tubulin activation is modulation of the structure of a switch element (the M-loop) from a disordered form in dimeric tubulin to a folded helical structure in microtubules.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f9cfd00b1f1ee769e381ac20f964e74
http://hdl.handle.net/10261/178957