Inhibition of astroglial hemichannels prevents synaptic transmission decline during spreading depression

Autor: Juan E. Tichauer, Matías Lira, Waldo Cerpa, Juan A. Orellana, Juan C. Sáez, Maximiliano Rovegno

Publikováno v: Biological Research, Vol 57, Iss 1, Pp 1-19 (2024)

Abstract Background Spreading depression (SD) is an intriguing phenomenon characterized by massive slow brain depolarizations that affect neurons and glial cells. This phenomenon is repetitive and produces a metabolic overload that increases secondar

Externí odkaz: https://doaj.org/article/cecf7704615944e397882f67e90d7298

Interferon-gamma ameliorates experimental autoimmune encephalomyelitis by inducing homeostatic adaptation of microglia

Autor: Juan E. Tichauer, Gabriel Arellano, Eric Acuña, Luis F. González, Nirmal R. Kannaiyan, Paola Murgas, Concepción Panadero-Medianero, Jorge Ibañez-Vega, Paula I. Burgos, Eileah Loda, Stephen D. Miller, Moritz J. Rossner, Peter J. Gebicke-Haerter, Rodrigo Naves

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Compelling evidence has shown that interferon (IFN)-γ has dual effects in multiple sclerosis and in its animal model of experimental autoimmune encephalomyelitis (EAE), with results supporting both a pathogenic and beneficial function. However, the

Externí odkaz: https://doaj.org/article/3d3b58825bbc464e9cd529da25273a52

Pannexin-1 channel opening is critical for COVID-19 pathogenesis

Autor: Geoffroy Lorin de la Grandmaison, Antonio Cibelli, David C. Spray, Juan E. Tichauer, Jean Dubuisson, Arielle Rosenberg, Ross H. Luu, Sandrine Belouzard, Eliana Scemes, Elisabeth Cramer-Bordé, Morgane Bomsel, Djillali Annane, Maximiliano Rovegno, Andrea Cottignies-Calamarte, Silvana Valdebenito, Eliseo A. Eugenin, Calude Capron

Publikováno v: iScience
iScience, Elsevier, 2021, pp.103478. ⟨10.1016/j.isci.2021.103478⟩
iScience, Vol 24, Iss 12, Pp 103478-(2021)
iScience, 2021, 24 (12), pp.103478. ⟨10.1016/j.isci.2021.103478⟩

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly rampaged worldwide, causing a pandemic of coronavirus disease (COVID -19), but the biology of SARS-CoV-2 remains under investigation. We demonstrate that both SARS-CoV-2 spike prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7d58ad9b51beb53b72c6f0ab951dccc
https://hal.archives-ouvertes.fr/hal-03456000

Transforming growth factor-β stimulates β amyloid uptake by microglia through Smad3-dependent mechanisms

Autor: Rommy von Bernhardi, Juan E. Tichauer

Publikováno v: JOURNAL OF NEUROSCIENCE RESEARCH
Artículos CONICYT
CONICYT Chile
instacron:CONICYT

Inflammatory cytokines and β amyloid (Aβ) induce activation of glial cells, leading to both protective and deleterious changes that are relevant for the pathogenesis of Alzheimer disease (AD). We have shown that astrocytes downregulate microglial c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98a31d29282954df6273b9762dcd58dd
https://doi.org/10.1002/jnr.23082

Age-dependent changes on tgf beta 1 smad3 pathway modify the pattern of microglial cell activation

Autor: Bernardita Soler, Laura Eugenín-von Bernhardi, Rommy von Bernhardi, Gigliola Ramírez, Betsi Flores, Juan E. Tichauer

Publikováno v: BRAIN, BEHAVIOR, AND IMMUNITY
Artículos CONICYT
CONICYT Chile
instacron:CONICYT

Aging is the main risk factor for Alzheimer's disease. Among other characteristics, it shows changes in inflammatory signaling that could affect the regulation of glial cell activation. We have shown that astrocytes prevent microglial cell cytotoxici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de41931311e85b87c73266bde64f5869