SMaRT modulation of tau isoforms rescues cognitive and motor impairments in a preclinical model of tauopathy

Autor: Javier Andrés Muñiz, Carolina Lucía Facal, Leandro Urrutia, Ramiro Clerici-Delville, Ana Damianich, Juan E. Ferrario, Germán Falasco, María Elena Avale

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)

Tau is a microtubule-associated protein predominantly expressed in neurons, which participates in microtubule polymerization and axonal transport. Abnormal tau metabolism leads to neurodegenerative diseases named tauopathies, such as Alzheimer’s di

Externí odkaz: https://doaj.org/article/36ed0e9e232c4960b582dd1a46c7cdb2

Regulation of Pleiotrophin and Fyn in the striatum of rats undergoing L-DOPA-induced dyskinesia

Autor: Mariano D. Saborido, Oscar S. Gershanik, Juan E. Ferrario, Gimena Gomez, Irene R. E. Taravini, M. Alejandra Bernardi

Publikováno v: Neuroscience Letters. 666:5-10

L-DOPA is the gold standard pharmacological therapy for symptomatic treatment of Parkinson´s disease (PD), however, its long-term use is associated with the emergence of L-DOPA-induced dyskinesia (LID). Understanding the underlying molecular mechani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226e9edbbc29325f36c08eba5f5bdd1a
https://doi.org/10.1016/j.neulet.2017.12.024

Yerba mate (Ilex paraguariensis) favors survival and growth of dopaminergic neurons in culture

Autor: Irene Rita Eloisa Taravini, Alejandra Bernardi, Marcela Schenk, Pedro Ballestero, Oscar S. Gershanik, Roy Rivero, Sandra N. Guerrero, Mariana Inés Ferrario, Gimena Gomez, Elena Avale, Juan E. Ferrario

The infusion from Ilex paraguariensis (popularly known as Yerba mate [YM]) produces the very popular South American beverage called mate (pronounced as “mateI” or maté), and its intake has been inversely associated with the development of Parkin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9be5653a2eab6a089f0619ebb3583cb
Wiley Online Library

Modulation of Tau Isoforms Imbalance Precludes Tau Pathology and Cognitive Decline in a Mouse Model of Tauopathy

Autor: Sonia Espindola, Jean-Marc Gallo, Juan E. Ferrario, Ana Damianich, Juan E. Belforte, Maria Elena Avale, Manuela Sartor, Rodrigo Javier Alvarez

Publikováno v: Espíndola, S L, Damianich, A, Alvarez, R J, Sartor, M, Belforte, J E, Ferrario, J E, Gallo, J-M & Avale, M E 2018, ' Modulation of Tau Isoforms Imbalance Precludes Tau Pathology and Cognitive Decline in a Mouse Model of Tauopathy ', Cell Reports, vol. 23, no. 3, pp. 709-715 . https://doi.org/10.1016/j.celrep.2018.03.079
Cell Reports, Vol 23, Iss 3, Pp 709-715 (2018)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
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The microtubule-associated protein tau regulates myriad neuronal functions, such as microtubule dynamics, axonal transport and neurite outgrowth. Tauopathies are neurodegenerative disorders characterized by the abnormal metabolism of tau, which accum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43a0dbce0308c51c0aeb258585fda120
https://www.sciencedirect.com/science/article/pii/S2211124718304406

Axon guidance in the developing ocular motor system and Duane retraction syndrome depends on Semaphorin signaling via alpha2-chimaerin

Autor: John K. Chilton, Oleg Lerner, James A. Van Allen, Pranetha Baskaran, Sarah Guthrie, Christopher Clark, Aenea C. Hendry, Mark Hintze, Juan E. Ferrario

Publikováno v: Proceedings of the National Academy of Sciences. 109:14669-14674

Eye movements depend on correct patterns of connectivity between cranial motor axons and the extraocular muscles. Despite the clinical importance of the ocular motor system, little is known of the molecular mechanisms underlying its development. We h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5925b4e4cfe37e336477fa66f3bc6de
https://doi.org/10.1073/pnas.1116481109