Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Juan E. Castillo-Fernandez"'
Autor:
Colette Christiansen, Louis Potier, Tiphaine C. Martin, Sergio Villicaña, Juan E. Castillo-Fernandez, Massimo Mangino, Cristina Menni, Pei-Chien Tsai, Purdey J. Campbell, Shelby Mullin, Juan R. Ordoñana, Olga Monteagudo, Perminder S. Sachdev, Karen A. Mather, Julian N. Trollor, Kirsi H. Pietilainen, Miina Ollikainen, Christine Dalgård, Kirsten Kyvik, Kaare Christensen, Jenny van Dongen, Gonneke Willemsen, Dorret I. Boomsma, Patrik K.E. Magnusson, Nancy L. Pedersen, Scott G. Wilson, Elin Grundberg, Tim D. Spector, Jordana T. Bell
Publikováno v:
EBioMedicine, Vol 103, Iss , Pp 105096- (2024)
Summary: Background: Type 2 diabetes (T2D) susceptibility is influenced by genetic and environmental factors. Previous findings suggest DNA methylation as a potential mechanism in T2D pathogenesis and progression. Methods: We profiled DNA methylation
Externí odkaz:
https://doaj.org/article/8370902b51f14421bc193f373f4db351
Autor:
Jenny van Dongen, Scott D. Gordon, Allan F. McRae, Veronika V. Odintsova, Hamdi Mbarek, Charles E. Breeze, Karen Sugden, Sara Lundgren, Juan E. Castillo-Fernandez, Eilis Hannon, Terrie E. Moffitt, Fiona A. Hagenbeek, Catharina E. M. van Beijsterveldt, Jouke Jan Hottenga, Pei-Chien Tsai, BIOS Consortium, Genetics of DNA Methylation Consortium, Josine L. Min, Gibran Hemani, Erik A. Ehli, Franziska Paul, Claudio D. Stern, Bastiaan T. Heijmans, P. Eline Slagboom, Lucia Daxinger, Silvère M. van der Maarel, Eco J. C. de Geus, Gonneke Willemsen, Grant W. Montgomery, Bruno Reversade, Miina Ollikainen, Jaakko Kaprio, Tim D. Spector, Jordana T. Bell, Jonathan Mill, Avshalom Caspi, Nicholas G. Martin, Dorret I. Boomsma
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The mechanisms underlying how monozygotic (or identical) twins arise are yet to be determined. Here, the authors investigate this in an epigenome-wide association study, showing that monozygotic twinning has a characteristic DNA methylation signature
Externí odkaz:
https://doaj.org/article/4deb6641205f44abb1762c5892e3dccd
Autor:
Irma Karabegović, Eliana Portilla-Fernandez, Yang Li, Jiantao Ma, Silvana C. E. Maas, Daokun Sun, Emily A. Hu, Brigitte Kühnel, Yan Zhang, Srikant Ambatipudi, Giovanni Fiorito, Jian Huang, Juan E. Castillo-Fernandez, Kerri L. Wiggins, Niek de Klein, Sara Grioni, Brenton R. Swenson, Silvia Polidoro, Jorien L. Treur, Cyrille Cuenin, Pei-Chien Tsai, Ricardo Costeira, Veronique Chajes, Kim Braun, Niek Verweij, Anja Kretschmer, Lude Franke, Joyce B. J. van Meurs, André G. Uitterlinden, Robert J. de Knegt, M. Arfan Ikram, Abbas Dehghan, Annette Peters, Ben Schöttker, Sina A. Gharib, Nona Sotoodehnia, Jordana T. Bell, Paul Elliott, Paolo Vineis, Caroline Relton, Zdenko Herceg, Hermann Brenner, Melanie Waldenberger, Casey M. Rebholz, Trudy Voortman, Qiuwei Pan, Myriam Fornage, Daniel Levy, Manfred Kayser, Mohsen Ghanbari
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
While coffee and tea consumption has been associated with risk of diseases, their mechanisms of action remain elusive. Here the authors present a large EWAS on coffee and tea consumption in cohorts of European and African-American ancestries, finding
Externí odkaz:
https://doaj.org/article/e843a6cca5f04b56a0da0b8c84340c1a
Autor:
Pei-Chien Tsai, Craig A. Glastonbury, Melissa N. Eliot, Sailalitha Bollepalli, Idil Yet, Juan E. Castillo-Fernandez, Elena Carnero-Montoro, Thomas Hardiman, Tiphaine C. Martin, Alice Vickers, Massimo Mangino, Kirsten Ward, Kirsi H. Pietiläinen, Panos Deloukas, Tim D. Spector, Ana Viñuela, Eric B. Loucks, Miina Ollikainen, Karl T. Kelsey, Kerrin S. Small, Jordana T. Bell
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-21 (2018)
Abstract Background Tobacco smoking is a risk factor for multiple diseases, including cardiovascular disease and diabetes. Many smoking-associated signals have been detected in the blood methylome, but the extent to which these changes are widespread
Externí odkaz:
https://doaj.org/article/3bba2d6c73104eca9851fbbee9580cd6
Autor:
Jordana T. Bell, Claudio D. Stern, Scott D. Gordon, Erik A. Ehli, Silvère M. van der Maarel, Jonathan Mill, Gibran Hemani, Hamdi Mbarek, Juan E. Castillo-Fernandez, Tim D. Spector, Allan F. McRae, Catharina E. M. van Beijsterveldt, Jouke-Jan Hottenga, Veronika V. Odintsova, Nicholas G. Martin, Jaakko Kaprio, Eilis Hannon, P. Eline Slagboom, Gonneke Willemsen, Bastiaan T. Heijmans, Sara N. Lundgren, Josine L. Min, Jenny van Dongen, Miina Ollikainen, Dorret I. Boomsma, Pei-Chien Tsai, Karen Sugden, Charles E. Breeze, Terrie E. Moffitt, Bruno Reversade, Lucia Daxinger, Franziska Paul, Fiona A. Hagenbeek, Eco J. C. de Geus, Grant W. Montgomery, T.D. Spector, Avshalom Caspi
Publikováno v:
Nature communications, 12(1):5618. Nature Publishing Group
Nature Communications
Nature Communications, 12(1):5618, 1-14. Nature Publishing Group
Hemani, G 2021, ' Identical twins carry a persistent epigenetic signature of early genome programming ', Nature Communications, vol. 12, no. 1, 5618 . https://doi.org/10.1038/s41467-021-25583-7
Nature Communications, 12(1). NATURE PORTFOLIO
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
van Dongen, J, Gordon, S D, Odintsova, V V, Mbarek, H, Hagenbeek, F A, van Beijsterveldt, C E M, Jan Hottenga, J, de Geus, E J C, Willemsen, G, Boomsma, D I, Genetics of DNA Methylation Consortium & BIOS Consortium 2021, ' Identical twins carry a persistent epigenetic signature of early genome programming ', Nature Communications, vol. 12, no. 1, 5618, pp. 1-14 . https://doi.org/10.1038/s41467-021-25583-7, https://doi.org/10.1038/s41467-021-25583-7
Nature Communications
Nature Communications, 12(1):5618, 1-14. Nature Publishing Group
Hemani, G 2021, ' Identical twins carry a persistent epigenetic signature of early genome programming ', Nature Communications, vol. 12, no. 1, 5618 . https://doi.org/10.1038/s41467-021-25583-7
Nature Communications, 12(1). NATURE PORTFOLIO
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
van Dongen, J, Gordon, S D, Odintsova, V V, Mbarek, H, Hagenbeek, F A, van Beijsterveldt, C E M, Jan Hottenga, J, de Geus, E J C, Willemsen, G, Boomsma, D I, Genetics of DNA Methylation Consortium & BIOS Consortium 2021, ' Identical twins carry a persistent epigenetic signature of early genome programming ', Nature Communications, vol. 12, no. 1, 5618, pp. 1-14 . https://doi.org/10.1038/s41467-021-25583-7, https://doi.org/10.1038/s41467-021-25583-7
The mechanisms underlying how monozygotic (or identical) twins arise are yet to be determined. Here, the authors investigate this in an epigenome-wide association study, showing that monozygotic twinning has a characteristic DNA methylation signature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c8782e417f5a11b5e6694746e20eb68
https://pure.amc.nl/en/publications/identical-twins-carry-a-persistent-epigenetic-signature-of-early-genome-programming(73725bc1-8f93-4e02-88e9-189d0ad79157).html
https://pure.amc.nl/en/publications/identical-twins-carry-a-persistent-epigenetic-signature-of-early-genome-programming(73725bc1-8f93-4e02-88e9-189d0ad79157).html
Autor:
Juan E. Castillo-Fernandez, Riccardo E. Marioni, Andrea A. Baccarelli, Luigi Ferrucci, Steve Horvath, Joel Schwartz, Daniel Levy, Luke C. Pilling, Rahul Gondalia, James S. Pankow, Naomi R. Wray, Allan C. Just, Ian J. Deary, Toshiko Tanaka, Melanie Waldenberger, Wen Zhang, Gao Xu, Allan F. McRae, Phil S. Tsaho, Holger Prokisch, James D. Stewart, Tim Assimes, Rory P. Wilson, Cavin K. Ward-Caviness, John M. Starr, Weihua Guan, Yun Li, Devin Absher, Pantel S. Vokonas, Peter M. Visscher, Mike Mendelson, Ann Zenobia Moore, Agha Golareh, Chunyu Liu, Jan Bressler, Eric A. Whitsel, Ake T. Lu, Pei-Chien Tsai, Joanne M. Murabito, Lifang Hou, Tim D. Spector, Annette Peters, Guosheng Zhang, Tianxiao Huan, Elena Colicino, Jordana T. Bell, Stefania Bandinelli, Brian H. Chen, Douglas P. Kiel
Publikováno v:
Aging (Albany NY)
Aging 12, 14092-14124 (2020)
Colicino, E, Marioni, R, Ward-Caviness, C, Gondalia, R, Guan, W, Chen, B H, Tsai, P-C, Huan, T, Xu, G, Agha, G, Schwartz, J, Vokonas, P, Just, A C, Starr, J, Mcrae, A F, Wray, N, Visscher, P, Bressler, J, Zhang, W, Toshiko, T, Moore, A Z, Pilling, L C, Zhang, G, Stewart, J, Li, Y, Hou, L, Castillo-Fernandez, J, Spector, T D, Kiel, D P, Murabito, J M, Liu, C, Mendelson, M, Assimes, T, Absher, D, Tsaho, P S, Lu, A T, Ferrucci, L, Wilson, R P, Waldenberger, M, Prokisch, H, Bandinelli, S, Bell, J T, Levy, D, Deary, I, Horvath, S, Pankow, J, Peters, A, Whitsel, E A & Baccarelli, A A 2020, ' Blood DNA methylation sites predict death risk in a longitudinal study of 12,300 individuals ', Aging, vol. 12, no. 14, pp. 14092—14124 . https://doi.org/10.18632/aging.103408
Aging 12, 14092-14124 (2020)
Colicino, E, Marioni, R, Ward-Caviness, C, Gondalia, R, Guan, W, Chen, B H, Tsai, P-C, Huan, T, Xu, G, Agha, G, Schwartz, J, Vokonas, P, Just, A C, Starr, J, Mcrae, A F, Wray, N, Visscher, P, Bressler, J, Zhang, W, Toshiko, T, Moore, A Z, Pilling, L C, Zhang, G, Stewart, J, Li, Y, Hou, L, Castillo-Fernandez, J, Spector, T D, Kiel, D P, Murabito, J M, Liu, C, Mendelson, M, Assimes, T, Absher, D, Tsaho, P S, Lu, A T, Ferrucci, L, Wilson, R P, Waldenberger, M, Prokisch, H, Bandinelli, S, Bell, J T, Levy, D, Deary, I, Horvath, S, Pankow, J, Peters, A, Whitsel, E A & Baccarelli, A A 2020, ' Blood DNA methylation sites predict death risk in a longitudinal study of 12,300 individuals ', Aging, vol. 12, no. 14, pp. 14092—14124 . https://doi.org/10.18632/aging.103408
DNA methylation has fundamental roles in gene programming and aging that may help predict mortality. However, no large-scale study has investigated whether site-specific DNA methylation predicts all-cause mortality. We used the Illumina-HumanMethylat
Autor:
Jordana T. Bell, George B. Ploubidis, Rachel Cooper, Juan E. Castillo-Fernandez, Jane Maddock, Andrew Wong, Diana Kuh, Rebecca Hardy, Marcus Richards, Ken K. Ong, Alissa Goodman
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Background DNA methylation (DNAm) age acceleration (AgeAccel) has been shown to be predictive of all-cause mortality but it is unclear what functional aspect/s of ageing it captures. We examine associations between four measures of AgeAccel in adults
Autor:
Jordana T. Bell, Juan E. Castillo-Fernandez, George B. Ploubidis, Meena Kumari, Therese Tillin, Esther Walton, Erin C. Dunn, Tom R. Gaunt, Kate Tilling, Alissa Goodman, Andrew D A C Smith, Hannah R Elliott, Caroline L Relton, Alun D. Hughes, Riccardo E. Marioni, Ian J. Deary, Tom Woofenden, Matthew Suderman, Simon R. Cox
Variation in DNA methylation (DNAm) is associated with multiple biological processes that track growth and development, ageing and age-related diseases. However, there is little understanding of what constitutes typical patterns of DNAm variation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e481a729ce208533e7bd5efe3ba1d73c
https://doi.org/10.1101/2021.09.18.460916
https://doi.org/10.1101/2021.09.18.460916
Autor:
Juan E. Castillo-Fernandez, Jordana T. Bell, Jane Maddock, Rebecca Hardy, George B. Ploubidis, Diana Kuh, Andrew Wong
Publikováno v:
Clinical Epigenetics
Background In the first study of its kind, we examine the association between growth and development in early life and DNAm age biomarkers in mid-life. Methods Participants were from the Medical Research Council National Survey of Health and Developm
Autor:
Lisa Schneper, Juan E. Castillo-Fernandez, Barbara E. Engelhardt, Isabella N. Grabski, Jordana T. Bell, Derek Aguiar, Sara McLanahan, Archit Verma, Daniel A. Notterman, De Vito R, Colter Mitchell
AO_SCPLOWBSTRACTC_SCPLOWThe Fragile Families Child Wellbeing Study (FFCWS) is a longitudinal cohort of ethnically diverse and primarily low socioeconomic status children and their families in the U.S. Here, we analyze DNA methylation data collected f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7473548a9e09a3d6423ca9084ffd0635
https://doi.org/10.1101/2021.05.20.444959
https://doi.org/10.1101/2021.05.20.444959