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pro vyhledávání: '"Juan Daniel Florez Weidinger"'
Autor:
Juan Daniel Florez Weidinger, Moritz Pfreundschuh, Diana Zörb, Ada Yee, Stephan Heyse, Felix Bärenz, Stephan Steigele
Publikováno v:
SLAS Discovery, Vol 29, Iss 5, Pp 100172- (2024)
The Cellular Thermal Shift Assay (CETSA) enables the study of protein-ligand interactions in a cellular context. It provides valuable information on the binding affinity and specificity of both small and large molecule ligands in a relevant physiolog
Externí odkaz:
https://doaj.org/article/075675c8c14844fba581ca65073a0d73
Autor:
Bharath Srinivasan, Juan Daniel Flórez Weidinger, Xiang Zhai, Guillaume Lemercier, Timothy Ikeda, Mark Brewer, Bairu Zhang, Stephan Heyse, Jonathan Wingfield, Stephan Steigele
Publikováno v:
SLAS Discovery, Vol 27, Iss 8, Pp 460-470 (2022)
Recent efforts for increasing the success in drug discovery focus on an early, massive, and routine mechanistic and/or kinetic characterization of drug-target engagement as part of a design-make-test-analyze strategy. From an experimental perspective
Externí odkaz:
https://doaj.org/article/a2126a1a1f8f429598c4f15e9ed9a831