Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Juan D, Goutman"'
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 13 (2021)
Noise-induced hearing loss has gained relevance as one of the most common forms of hearing impairment. The anatomical correlates of hearing loss, principally cell damage and/or death, are relatively well-understood histologically. However, much less
Externí odkaz:
https://doaj.org/article/61032a31901d4372a5c4dd5ff8d84ac6
Publikováno v:
The Journal of Neuroscience. 41:6812-6821
For normal cochlear function, outer hair cells (OHCs) require a precise control of intracellular Ca2+ levels. In the absence of regulatory elements such as proteinaceous buffers or extrusion pumps, OHCs degenerate, leading to profound hearing impairm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41f6148439303d462d9a165fab33806d
https://doi.org/10.1523/jneurosci.3008-20.2021
https://doi.org/10.1523/jneurosci.3008-20.2021
Autor:
Nicolas Michalski, Juan D Goutman, Sarah Marie Auclair, Jacques Boutet de Monvel, Margot Tertrais, Alice Emptoz, Alexandre Parrin, Sylvie Nouaille, Marc Guillon, Martin Sachse, Danica Ciric, Amel Bahloul, Jean-Pierre Hardelin, Roger Bryan Sutton, Paul Avan, Shyam S Krishnakumar, James E Rothman, Didier Dulon, Saaid Safieddine, Christine Petit
Publikováno v:
eLife, Vol 6 (2017)
Hearing relies on rapid, temporally precise, and sustained neurotransmitter release at the ribbon synapses of sensory cells, the inner hair cells (IHCs). This process requires otoferlin, a six C2-domain, Ca2+-binding transmembrane protein of synaptic
Externí odkaz:
https://doaj.org/article/0573827227564a46bbf876f5400e53e1
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
J Physiol
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
J Physiol
Ribbon-class synapses in the ear achieve analog to digital transformation of a continuously graded membrane potential to all-or-none spikes. In mammals, several auditory nerve fibers (ANFs) carry information from each inner hair cell (IHC) to the bra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef9443da47d52c8dee006788770f6971
Wiley Online Library
Wiley Online Library
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Humans can recognize differences in sound intensity of up to 6 orders of magnitude. However, it is not clear how this is achieved and what enables our auditory systems to encode such a gradient. Özçete & Moser (2021) report in this issue that the k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ddd6d7ebd9a8c0f1218006e74d011db
https://www.embopress.org/doi/abs/10.15252/embj.2020107531
https://www.embopress.org/doi/abs/10.15252/embj.2020107531
Publikováno v:
J Neurosci
For normal cochlear function, outer hair cells (OHCs) require a precise control of intracellular Ca(2+) levels. In the absence of regulatory elements such as proteinaceous buffers or extrusion pumps, OHCs degenerate, leading to profound hearing impai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d0dc78475608ee0afe1f442b785bffbb
https://pubmed.ncbi.nlm.nih.gov/34253627
https://pubmed.ncbi.nlm.nih.gov/34253627
Autor:
Irina Marcovich, Agustín Eduardo Carpaneto Freixas, Sabina Domene, Lucia Salatino, Tais Castagnola, Paola V. Plazas, Marcelo J. Moglie, Juan D. Goutman, Carolina Wedemeyer, Sofía Gallino, Ana Belén Elgoyhen
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
The lateral line (LL) is a sensory system that allows fish and amphibians to detect water currents. LL responsiveness is modulated by efferent neurons which aid to distinguish between external and self-generated stimuli, maintaining sensitivity to re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc1ea04a10567ab29c79cc5774f650e9
http://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.1772-20.2020
http://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.1772-20.2020
For normal cochlear function, outer hair cells (OHCs) require a precise regulation of intracellular Ca2+ levels. Influx of Ca2+ occurs both at the stereocillia tips and through the basolateral membrane. In this latter compartment, two different origi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e79edabe63d4ddc3134f71ad491b3666
https://doi.org/10.1101/2020.08.02.233205
https://doi.org/10.1101/2020.08.02.233205
Autor:
Juan D. Goutman
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Inner hair cells (IHCs) in the cochlea are the mammalian phono-receptors, transducing sound energy into graded changes in membrane potentials, the so called “receptor potentials.” Ribbon synapses between IHCs and auditory nerve neurons are respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16da09eabce1d1ca80da8e3dcb1eaaaa
https://doi.org/10.1073/pnas.1706160114
https://doi.org/10.1073/pnas.1706160114
Autor:
Ana Belén Elgoyhen, Valeria C. Castagna, Luis E. Boero, Juan D. Goutman, María Eugenia Gómez-Casati, Mariano N. Di Guilmi
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Cochlear synaptopathy produced by exposure to noise levels that cause only transient auditory threshold elevations is a condition that affects many people and is believed to contribute to poor speech discrimination in noisy environments. These functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a02a7641a27bd122ca226ac0d7ae56e
http://www.jneurosci.org/content/38/34/7440.long
http://www.jneurosci.org/content/38/34/7440.long