Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Juan Crespo-Barreto"'
Autor:
Bertrand Perroud, Paymaan Jafar-Nejad, William R Wikoff, Jennifer R Gatchel, Lu Wang, Dinesh K Barupal, Juan Crespo-Barreto, Oliver Fiehn, Huda Y Zoghbi, Rima Kaddurah-Daouk
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70610 (2013)
We have shown that lithium treatment improves motor coordination in a spinocerebellar ataxia type 1 (SCA1) disease mouse model (Sca1(154Q/+)). To learn more about disease pathogenesis and molecular contributions to the neuroprotective effects of lith
Externí odkaz:
https://doaj.org/article/177e8a4078eb4c0795d7a9002d0001a0
Publikováno v:
PLoS Genetics, Vol 6, Iss 7, p e1001021 (2010)
Spinocerebellar ataxia type 1 (SCA1) is a dominantly inherited neurodegenerative disease caused by expansion of a CAG repeat that encodes a polyglutamine tract in ATAXIN1 (ATXN1). Molecular and genetic data indicate that SCA1 is mainly caused by a ga
Externí odkaz:
https://doaj.org/article/49e72915fe0040d79f21b647436d7f30
Autor:
Anna R. Panchenko, Stanley Lipkowitz, Andrew L. Cangelosi, Juan Crespo-Barreto, Benjamin A. Shoemaker, Ke Ma, Stephen C. Kales, Minghui Li
Fig. S1. The distribution of unfolding and binding free energy changes for Single, Recurrent and Random class mutations for all states in CBL activation cycle. Fig.S2. The distribution of local RMSD of mutant structures for Single, Recurrent and Rand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb546c494c2f73006222586e7feb390
https://doi.org/10.1158/0008-5472.22409519.v1
https://doi.org/10.1158/0008-5472.22409519.v1
Autor:
Anna R. Panchenko, Stanley Lipkowitz, Andrew L. Cangelosi, Juan Crespo-Barreto, Benjamin A. Shoemaker, Ke Ma, Stephen C. Kales, Minghui Li
Detailed description of methods for computational modeling and analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca8c934d75e8eafa86e7076d2ad1688
https://doi.org/10.1158/0008-5472.22409516.v1
https://doi.org/10.1158/0008-5472.22409516.v1
Autor:
Anna R. Panchenko, Stanley Lipkowitz, Andrew L. Cangelosi, Juan Crespo-Barreto, Benjamin A. Shoemaker, Ke Ma, Stephen C. Kales, Minghui Li
Oncogenic mutations in the monomeric Casitas B-lineage lymphoma (Cbl) gene have been found in many tumors, but their significance remains largely unknown. Several human c-Cbl (CBL) structures have recently been solved, depicting the protein at differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34514988a1daef25bcffcf099d6e7902
https://doi.org/10.1158/0008-5472.c.6507806
https://doi.org/10.1158/0008-5472.c.6507806
Autor:
June Feng, Connie S Sosnoff, John T Bernert, Benjamin C Blount, Yao Li, Arseima Y Del Valle-Pinero, Heather L Kimmel, Dana M van Bemmel, Sharyn M Rutt, Juan Crespo-Barreto, Nicolette Borek, Kathryn C Edwards, Ricky Alexander, Stephen Arnstein, Charles Lawrence, Andrew Hyland, Maciej L Goniewicz, Imran Rehmani, Brittany Pine, Vincent Pagnotti, Erin Wade, James Sandlin, Zuzheng Luo, Sujeewa Piyankarage, Dorothy K Hatsukami, Stephen S Hecht, Kevin P Conway, Lanqing Wang
Publikováno v:
Nicotine Tob Res
Introduction The Population Assessment of Tobacco and Health (PATH) Study is a longitudinal cohort study on tobacco use behavior, attitudes and beliefs, and tobacco-related health outcomes, including biomarkers of tobacco exposure in the U.S. populat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27da9b06cc51aefbeda2326964208e60
https://doi.org/10.1093/ntr/ntab206
https://doi.org/10.1093/ntr/ntab206
Publikováno v:
Human & Experimental Toxicology. 35:1149-1160
Nicotinamide riboside (NR) is a naturally occurring form of vitamin B3 present in trace amounts in some foods. Like niacin, it has been shown to be a precursor in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). The safety of Niagen™,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84189e4d47aee117aef2142d442c3a32
https://doi.org/10.1177/0960327115626254
https://doi.org/10.1177/0960327115626254
Autor:
Alan M. Krensky, Carol Clayberger, Seok Joo Kwon, Juan Crespo-Barreto, Dong Seok Kim, Tianhong Wang, Wei Zhang
Publikováno v:
J Immunol
Kruppel-like factor (KLF) 13 is a transcription factor that positively regulates expression of the chemokine RANTES 3–5 d after activation of T cells. In this study, we document a key role for KLF13 in the expression of IL-4 in CD4+ T cells. Gene e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::446ca2ef7215d9b38a2e744349fabb07
https://doi.org/10.4049/jimmunol.1302830
https://doi.org/10.4049/jimmunol.1302830
Autor:
Yan Gao, Angela N. Carter, Hyojin Kang, Chad A. Shaw, Juan Crespo-Barreto, Harry T. Orr, Peng Yu, Caleigh Mandel-Brehm, Huda Y. Zoghbi, Adriano Flora, John D. Fryer
Publikováno v:
Science. 334:690-693
Spinocerebellar ataxia type 1 (SCA1) is a fatal neurodegenerative disease caused by expansion of a translated CAG repeat in Ataxin-1 (ATXN1). To determine the long-term effects of exercise, we implemented a mild exercise regimen in a mouse model of S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::061dfb57c3e563f028335936ee4bbacc
https://doi.org/10.1126/science.1212673
https://doi.org/10.1126/science.1212673
Autor:
Milton J. Finegold, Huda Y. Zoghbi, John D. Fryer, Juan Crespo-Barreto, Harry T. Orr, Aaron B. Bowman, Jeong Soo Hong, Farrah Kheradmand, Juliette J. Kahle, Hyojin Kang, Yoontae Lee, Yan Gao
Publikováno v:
Developmental Cell. 21:746-757
Summary Although expansion of CAG repeats in ATAXIN1 ( ATXN1 ) causes Spinocerebellar ataxia type 1, the functions of ATXN1 and ATAXIN1-Like (ATXN1L) remain poorly understood. To investigate the function of these proteins, we generated and characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87256c63cad9dff5878c9fe20afa5219
https://doi.org/10.1016/j.devcel.2011.08.017
https://doi.org/10.1016/j.devcel.2011.08.017