Expression of alternative NADH dehydrogenases (NDH‐2) in the phytopathogenic fungus Ustilago maydis

Autor: Deyamira Matuz‐Mares, Genaro Matus‐Ortega, Christian Cárdenas‐Monroy, Lucero Romero‐Aguilar, Juan Carlos Villalobos‐Rocha, Héctor Vázquez‐Meza, Guadalupe Guerra‐Sánchez, Antonio Peña‐Díaz, Juan Pablo Pardo

Publikováno v: FEBS Open Bio, Vol 8, Iss 8, Pp 1267-1279 (2018)

Type 2 alternative NADH dehydrogenases (NDH‐2) participate indirectly in the generation of the electrochemical proton gradient by transferring electrons from NADH and NADPH into the ubiquinone pool. Due to their structural simplicity, alternative N

Externí odkaz: https://doaj.org/article/83b8be2bd7144a098004047cd7a9202e

Benzoic Acid Derivatives with Trypanocidal Activity: Enzymatic Analysis and Molecular Docking Studies toward Trans-Sialidase

Autor: Muhammad Kashif, Antonio Moreno-Herrera, Juan Carlos Villalobos-Rocha, Benjamín Nogueda-Torres, Jaime Pérez-Villanueva, Karen Rodríguez-Villar, José Lius Medina-Franco, Peterson de Andrade, Ivone Carvalho, Gildardo Rivera

Publikováno v: Molecules, Vol 22, Iss 11, p 1863 (2017)

Chagas, or American trypanosomiasis, remains an important public health problem in developing countries. In the last decade, trans-sialidase has become a pharmacological target for new anti-Chagas drugs. In this work, the aims were to design and find

Externí odkaz: https://doaj.org/article/5572517c40ae4c0ebd337d77f6a7cc9a

Esters of quinoxaline-7-carboxylate-1,4-di-N-oxide as Trichomonas vaginalis triosephosphate isomerase inhibitors

Autor: Rosa Moo-Puc, Claudia G. Benítez-Cardoza, José Luis Vique-Sánchez, Juan Carlos Villalobos-Rocha, Antonio Monge, Gildardo Rivera, Alma D Paz-González, Isidro Palos

Publikováno v: Acta Pharmaceutica, Vol 71, Iss 3, Pp 485-495 (2021)
Acta Pharmaceutica
Volume 71
Issue 3

Trichomoniasis is a public health problem worldwide. Trichomoniasis treatment consists of the use of nitroimidazole derivatives; however, therapeutic ineffectiveness occurs in 5 to 20 % of the cases. Therefore, it is essential to propose new pharmaco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::853e71cf958df08941cfbf70128c133d
https://doi.org/10.2478/acph-2021-0032

Computational drug repositioning for chagas disease using protein-ligand interaction profiling

Autor: V. Joachim Haupt, Carlos A. García-Pérez, Citlali Vázquez, Juan Carlos Villalobos-Rocha, Emma Saavedra, Sebastian Salentin, Alfredo Juárez-Saldivar, Nuria E. Campillo, Verónica Herrera-Mayorga, Francisco Reyes-Espinosa, Gildardo Rivera, Michael Schroeder

Publikováno v: Int. J. Mol. Sci. 21:4270 (2020)
Digital.CSIC. Repositorio Institucional del CSIC
instname
International Journal of Molecular Sciences
Volume 21
Issue 12
International Journal of Molecular Sciences, Vol 21, Iss 4270, p 4270 (2020)

Chagas disease, caused by Trypanosoma cruzi (T. cruzi), affects nearly eight million people worldwide. There are currently only limited treatment options, which cause several side effects and have drug resistance. Thus, there is a great need for a no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80aec3565ac9f21c45640b40f2f1c34b
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=59506

A Practical Green Synthesis and Biological Evaluation of Benzimidazoles Against Two Neglected Tropical Diseases: Chagas and Leishmaniasis

Autor: Gildardo Rivera, Luvia Enid Sánchez-Torres, Bimal K. Banik, Benjamín Nogueda-Torres, Selina Samano, Debashis Bandyopadhyay, Juan Carlos Villalobos-Rocha

Publikováno v: Current medicinal chemistry. 24(41)

Antimicrobial resistance is an ever-increasing problem throughout the world and has already reached severe proportions. Two very common neglected tropical diseases are Chagas' disease and leishmaniasis. Chagas' disease is a severe health problem, mai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c56048242545a88fc5ca45951a8f1d
https://pubmed.ncbi.nlm.nih.gov/23317160