Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Juan Carlos Murciano"'
Autor:
Victoria Stepanova, Juan-Carlos Murciano, Mortimer Poncz, Oscar A. Marcos-Contreras, Bi-Sen Ding, Douglas B. Cines, Sergei Zaitsev, Vladimir R. Muzykantov, John P. Atkinson, M. Anna Kowalska, Samira Tliba, Alice Kuo, Dirk Spitzer
Publikováno v:
Blood. 115:5241-5248
Plasminogen activators (PAs) are used to treat life-threatening thrombosis, but not for thromboprophylaxis because of rapid clearance, risk of bleeding, and central nervous system (CNS) toxicity. We describe a novel strategy that may help to overcome
Autor:
Sergei, Zaitsev, Sergei, Zaitzev, Dirk, Spitzer, Juan-Carlos, Murciano, Bi-Sen, Ding, Samira, Tliba, M Anna, Kowalska, Khalil, Bdeir, Alice, Kuo, Victoria, Stepanova, John P, Atkinson, Mortimer, Poncz, Douglas B, Cines, Vladimir R, Muzykantov
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 332:1022-1031
Chemical coupling to carrier red blood cells (RBCs) converts tissue type plasminogen activator (tPA) from a problematic therapeutic into a safe agent for thromboprophylaxis. The goal of this study was to develop a more clinically relevant recombinant
Publikováno v:
Journal of Controlled Release. 139:190-196
Coupling plasminogen activators to carrier red blood cells (RBC) prolongs their life-time in the circulation and restricts extravascular side effects, thereby allowing their utility for short-term thromboprophylaxis. Unlike constitutively active plas
Autor:
Douglas B. Cines, Sergei Zaitsev, Vladimir R. Muzykantov, Scott E. Kasner, Dmitriy N. Atochin, Paul L. Huang, Juan-Carlos Murciano, Kumkum Ganguly, Bi-Sen Ding, Kristina Danielyan
Publikováno v:
Circulation. 118:1442-1449
Background— Cerebrovascular thrombosis is a major source of morbidity and mortality after surgery, but thromboprophylaxis in this setting is limited because of the formidable risk of perioperative bleeding. Thrombolytics (eg, tissue-type plasminoge
Autor:
Vladimir R. Muzykantov, Douglas B. Cines, Juan-Carlos Murciano, Sergei Zaitsev, Ronald P. Taylor, Tatiana Krasik, Kristina Danielyan, Steven J.M. Jones, Kumkum Ganguly, Steven M. Pincus
Publikováno v:
Blood. 108:1895-1902
Plasminogen activators (PAs) are not used for thromboprophylaxis due to rapid clearance, bleeding, and extravascular toxicity. We describe a novel strategy that overcomes these limitations. We conjugated tissue-type PA (tPA) to a monoclonal antibody
Autor:
John W. Weisel, Jim Torbet, Vladimir R. Muzykantov, Amy Seagraves, Tomas Scheiner, Harry Ischiropoulos, Marc S. Penn, Leonor Thomson, Gaston Vilaire, Juan Carlos Murciano, Joel S. Bennett, Caryn Vadseth, Stanley L. Hazen, Chandrasekaran Nagaswami, José M. Souza
Publikováno v:
Journal of Biological Chemistry. 279:8820-8826
Formation of nitric oxide-derived oxidants has been linked to development of atherosclerosis and associated thrombotic complications. Although systemic levels of protein nitrotyrosine predict risk for coronary artery disease, neither specific protein
Autor:
Vladimir R. Muzykantov, Juan-Carlos Murciano, Michael Koval, Silvia Muro, Christine Gajewski, Xiumin Cui
Publikováno v:
American Journal of Physiology-Cell Physiology. 285:C1339-C1347
Nanotechnologies promise new means for drug delivery. ICAM-1 is a good target for vascular immunotargeting of nanoparticles to the perturbed endothelium, although endothelial cells do not internalize monomeric anti-ICAM-1 antibodies. However, couplin
Autor:
Douglas B. Cines, Sandra Medinilla, Juan-Carlos Murciano, Donald Eslin, Vladimir R. Muzykantov, Elena N. Atochina
Publikováno v:
Nature Biotechnology. 21:891-896
A fibrinolytic agent consisting of a tissue-type plasminogen activator (tPA) coupled to the surface of red blood cells (RBCs) can dissolve nascent clots from within the clot, in a Trojan horse-like strategy, while having minimal effects on preexistin
Autor:
Arnaud Scherpereel, Giuseppe G. Pietra, Rainer Wiewrodt, Harry Ischiropoulos, Sayed A. Shah, Charalambos C. Solomides, Melpo Christofidou-Solomidou, Vladimir R. Muzykantov, Steven M. Albelda, Juan-Carlos Murciano, Stephen J. Kennel
Publikováno v:
The American Journal of Pathology. 160:1155-1169
Oxidative endothelial stress, leukocyte transmigration, and pulmonary thrombosis are important pathological factors in acute lung injury/acute respiratory distress syndrome (ALI/ARDS). Vascular immunotargeting of the H 2 O 2 -generating enzyme glucos
Autor:
Khalil Bdeir, Juan-Carlos Murciano, John Tomaszewski, Lauren Koniaris, Jose Martinez, Douglas B. Cines, Vladimir R. Muzykantov, Abd Al-Roof Higazi
Publikováno v:
Blood. 96:1820-1826
The role of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) in fibrinolysis remains unsettled. The contribution of uPA may depend on the vascular location, the physical properties of the clot, and its impact on tissue function. To