Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Juan Carlos Mobarec"'
Autor:
Ludovico Pipitò, Christopher A. Reynolds, Juan Carlos Mobarec, Owen Vickery, Giuseppe Deganutti
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1607 (2022)
After the SARS-CoV-2 Wuhan variant that gave rise to the pandemic, other variants named Delta, Omicron, and Omicron-2 sequentially became prevalent, with mutations spread around the viral genome, including on the spike (S) protein; in order to unders
Externí odkaz:
https://doaj.org/article/06893b8b736a45a8894b7152a92715d3
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 10, p e1002193 (2011)
Extensive experimental information supports the formation of ligand-specific conformations of G protein-coupled receptors (GPCRs) as a possible molecular basis for their functional selectivity for signaling pathways. Taking advantage of the recently
Externí odkaz:
https://doaj.org/article/576ce84612a84b07b553f83b0ae19740
Autor:
Giovanna Ghirlanda, Patrick M. Sexton, Juliana E. Milburn, Arthur Christopoulos, Maoqing Dong, Denise Wootten, Christopher A. Reynolds, Rafael Alcala-Torano, Juan Carlos Mobarec, Carolyn E. Clark, Sweta R. Raval, Kaleeckal G. Harikumar, Laurence J. Miller
Publikováno v:
Biochem Pharmacol
The secretin receptor is a prototypic class B GPCR with substantial and broad pharmacologic importance. The aim of this project was to develop a high affinity selective antagonist as a new and important pharmacologic tool and to aid stabilization of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a1704710372a14db4f7d2b7f9b7a4ca
https://europepmc.org/articles/PMC7299832/
https://europepmc.org/articles/PMC7299832/
Autor:
Caroline A. Hick, Juan Carlos Mobarec, Patrick M. Sexton, Thomas P. Sakmar, Cassandra Koole, Christopher A. Reynolds
Publikováno v:
The Journal of Biological Chemistry
The glucagon-like peptide-1 receptor (GLP-1R) is a key therapeutic target in the management of type II diabetes mellitus, with actions including regulation of insulin biosynthesis and secretion, promotion of satiety, and preservation of β-cell mass.
Autor:
Richard E. Weaver, Daniel Donnelly, Mark Wigglesworth, Juan Carlos Mobarec, Christopher A. Reynolds
Publikováno v:
Biochemical Pharmacology
Graphical abstract
TIP39 (“tuberoinfundibular peptide of 39 residues”) acts via the parathyroid hormone 2 receptor, PTH2, a Family B G protein-coupled receptor (GPCR). Despite the importance of GPCRs in human physiology and pharmacotherapy,
TIP39 (“tuberoinfundibular peptide of 39 residues”) acts via the parathyroid hormone 2 receptor, PTH2, a Family B G protein-coupled receptor (GPCR). Despite the importance of GPCRs in human physiology and pharmacotherapy,
Autor:
Laurence J. Miller, Patrick M. Sexton, John Simms, Kevin J. Smith, Juan Carlos Mobarec, Emilia Elizabeth Savage, Mengjie Liu, Philip E. Thompson, Denise Wootten, Arthur Christopoulos, Rohan Sridhar, Sebastian G.B. Furness, Christopher A. Reynolds, Cassandra Koole, Kavita Pabreja
Publikováno v:
Cell
Summary Ligand-directed signal bias offers opportunities for sculpting molecular events, with the promise of better, safer therapeutics. Critical to the exploitation of signal bias is an understanding of the molecular events coupling ligand binding t
Autor:
Valentina Rippa, Ilka B. Bischofs, Patricia Sauer, Juan Carlos Mobarec, Lorenz Adlung, Peter Kolb, Diana Wolf
Publikováno v:
Nucleic Acids Research
ComA-like transcription factors regulate the quorum response in numerous Gram-positive bacteria. ComA proteins belong to the tetrahelical helix-turn-helix superfamily of transcriptional activators, which bind as homodimers to inverted sequence repeat
Autor:
Juan Carlos Mobarec, Christopher A. Reynolds, Michael J. Woolley, John Simms, Alex C. Conner, David R. Poyner
The extracellular loop 2 (ECL2) region is the most conserved of the three ECL domains in family B G protein-coupled receptors (GPCRs) and has a fundamental role in ligand binding and activation across the receptor super-family. ECL2 is fundamental fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609a3b08b96c679c1e0365080ef49dd4
https://publications.aston.ac.uk/id/eprint/30885/1/Molecular_functions_of_ECL2_of_CGRP.pdf
https://publications.aston.ac.uk/id/eprint/30885/1/Molecular_functions_of_ECL2_of_CGRP.pdf
Autor:
Fiona H. Marshall, Juan Carlos Mobarec, Susan H. Brown, James C. Errey, Stephen P. Andrews, Jonathan S. Mason, Malcolm Peter Weir, Kelly N. Steele, Ali Jazayeri, Robert M. Cooke, A. O'Brien, Charlotte Fieldhouse, Iryna Teobald, Alastair J. H. Brown, Brown Giles Albert, Bortolato Andrea, John A. Christopher, Asma H. Baig, Chris de Graaf, Stacey M. Southall, Steve P. Watson, Krzysztof Okrasa, Miles Congreve
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:126611
A series of novel allosteric antagonists of the GLP-1 receptor (GLP-1R), exemplified by HTL26119, are described. SBDD approaches were employed to identify HTL26119, exploiting structural understanding of the allosteric binding site of the closely rel
Autor:
Simon J. Dowell, Cathryn Weston, Harriet A. Watkins, Graham Ladds, Ian Winfield, Rose Hodgson, Archna Shah, David R. Poyner, David A. Woodcock, Juan Carlos Mobarec, Matthew J. Harris, Christopher A. Reynolds
Publikováno v:
The Journal of Biological Chemistry
The calcitonin gene-related peptide (CGRP) family of G protein-coupled receptors (GPCRs) is formed through the association of the calcitonin receptor-like receptor (CLR) and one of three receptor activity-modifying proteins (RAMPs). Binding of one of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1d24ed56caf4393db55fbd6a5336e31
https://www.repository.cam.ac.uk/handle/1810/260854
https://www.repository.cam.ac.uk/handle/1810/260854