Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Juan Carlos López, Alfonso"'
Autor:
Haroon Arshad, Juan Carlos López Alfonso, Raimo Franke, Katina Michaelis, Leonardo Araujo, Aamna Habib, Yuliya Zboromyrska, Eva Lücke, Emilia Strungaru, Manas K. Akmatov, Haralampos Hatzikirou, Michael Meyer-Hermann, Astrid Petersmann, Matthias Nauck, Mark Brönstrup, Ursula Bilitewski, Laurent Abel, Jorg Sievers, Jordi Vila, Thomas Illig, Jens Schreiber, Frank Pessler
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-18 (2019)
Abstract Background There continues to be a great need for better biomarkers and host-directed treatment targets for community-acquired pneumonia (CAP). Alterations in phospholipid metabolism may constitute a source of small molecule biomarkers for a
Externí odkaz:
https://doaj.org/article/3d9601556c6342fabedbc34fda639d5e
Autor:
Haroon Arshad, Anastasios Siokis, Raimo Franke, Aamna Habib, Juan Carlos López Alfonso, Yuliya Poliakova, Eva Lücke, Katina Michaelis, Mark Brönstrup, Michael Meyer-Hermann, Ursula Bilitewski, Jordi Vila, Laurent Abel, Thomas Illig, Jens Schreiber, Frank Pessler
Publikováno v:
Cells, Vol 11, Iss 15, p 2283 (2022)
Amino acids and their metabolites are key regulators of immune responses, and plasma levels may change profoundly during acute disease states. Using targeted metabolomics, we evaluated concentration changes in plasma amino acids and related metabolit
Externí odkaz:
https://doaj.org/article/a1f59016816e4cf3bbaba5e6c03a6d2d
Autor:
Michael Meyer-Hermann, Siegfried Weiss, Sara Leschner, Juan Carlos López Alfonso, Haralampos Hatzikirou
Intentional bacterial infections can produce efficacious antitumor responses in mice, rats, dogs, and humans. However, low overall success rates and intense side effects prevent such approaches from being employed clinically. In this work, we titered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::190ae0a952ad0c7d6fe85c4cf73e13fa
https://doi.org/10.1158/0008-5472.c.6509712
https://doi.org/10.1158/0008-5472.c.6509712
Autor:
Michael Meyer-Hermann, Siegfried Weiss, Sara Leschner, Juan Carlos López Alfonso, Haralampos Hatzikirou
(Table S1) Control parameter values considered in the tumor-effector cell recruitment model - (Table S2) Parameter values estimated from the set of experiments corresponding to infection loads of 10^3 bacteria. - (Table S3) Parameter values estimated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00a36780bf801db939a33b72ec2f8554
https://doi.org/10.1158/0008-5472.22417005.v1
https://doi.org/10.1158/0008-5472.22417005.v1
Autor:
Eric A. Welsh, Kamran Ahmed, James J. Mulé, Steven A. Eschrich, Heiko Enderling, Louis B. Harrison, Juan Carlos López Alfonso, Jamie K. Teer, Javier F. Torres-Roca, John L. Cleveland, G. Daniel Grass, Shari Pilon-Thomas
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 11, Pp 1110-1122 (2021)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 11, Pp 1110-1122 (2021)
Radiotherapy efficacy is the result of radiation-mediated cytotoxicity coupled with stimulation of antitumor immune responses. We develop an in silico 3-dimensional agent-based model of diverse tumor-immune ecosystems (TIES) represented as anti- or p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfebdcf53b0ba923344c6d38319c679c
https://doi.org/10.1016/j.neo.2021.09.003
https://doi.org/10.1016/j.neo.2021.09.003
Autor:
Clifton D. Fuller, Juan Carlos López Alfonso, Nikhil P. Joshi, Nicole Dorio, Jacob G. Scott, Neil M. Woody, Shlomo A. Koyfman, Peng Qi, Jeremy Donaghue, Eric Murray, David Majkszak, Kristy K. Brock, Shireen Parsai, Richard L.J. Qiu
Publikováno v:
Journal of Applied Clinical Medical Physics
Purpose Prior in silico simulations propose that Temporally Feathered Radiation Therapy (TFRT) may reduce toxicity related to head and neck radiation therapy. In this study we demonstrate a step‐by‐step guide to TFRT planning with modern treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a379d7bef03b9ca3644ce8d116347651
https://doi.org/10.1002/acm2.12893
https://doi.org/10.1002/acm2.12893
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89380 (2014)
Tumor heterogeneity is widely considered to be a determinant factor in tumor progression and in particular in its recurrence after therapy. Unfortunately, current medical techniques are unable to deduce clinically relevant information about tumor het
Externí odkaz:
https://doaj.org/article/105b740db235414c98bbca630a8e2a3a
Autor:
Pietro, Mascheroni, Symeon, Savvopoulos, Juan Carlos López, Alfonso, Michael, Meyer-Hermann, Haralampos, Hatzikirou
Publikováno v:
Communications medicine. 1
In clinical practice, a plethora of medical examinations are conducted to assess the state of a patient's pathology producing a variety of clinical data. However, investigation of these data faces two major challenges. Firstly, we lack the knowledge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b30e727ec79cf6a7bbc594727b68f816
https://pubmed.ncbi.nlm.nih.gov/35602187
https://pubmed.ncbi.nlm.nih.gov/35602187
Autor:
Markus Cornberg, Jennifer Debarry, Wen-Juei Jeng, Sebastian Binder, Paul Gineste, Maximilian Wübbolding, Chun-Yen Lin, Juan Carlos López Alfonso, Heiner Wedemeyer, Anke R. M. Kraft, Michael Meyer Hermann, Benjamin Maasoumy, Rong-Nan Chien, Christine S. Falk, Christoph Höner zu Siederdissen
Publikováno v:
Hepatology communications
United States
Hepatology Communications
Hepatol Commun
United States
Hepatology Communications
Hepatol Commun
Soluble immune markers (SIMs) are associated with the risk of virological relapse in HBeAg‐negative patients with chronic hepatitis B after discontinuation of nucleos(t)ide analogue therapy. Machine learning identified a combination of five SIMs (I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5456ad8753059cf6e8cd6b2faf330e8f
https://hdl.handle.net/10033/622692
https://hdl.handle.net/10033/622692
Autor:
Pietro Mascheroni, Symeon Savvopoulos, Juan Carlos López Alfonso, Michael Meyer-Hermann, Haralampos Hatzikirou
In clinical practice, a plethora of medical examinations are conducted to assess the state of a patient’s pathology producing a variety of clinical data. However, exploiting these data faces the following challenges: (C1) we lack the knowledge of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9042074bd8ed775ecd51f6007a92c264