Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors

Autor: Jürgen Brem, Tharindi Panduwawala, Jon Ulf Hansen, Joanne Hewitt, Edgars Liepins, Pawel Donets, Laura Espina, Alistair J. M. Farley, Kirill Shubin, Gonzalo Gomez Campillos, Paula Kiuru, Shifali Shishodia, Daniel Krahn, Robert K. Leśniak, Juliane Schmidt, Karina Calvopiña, María-Carmen Turrientes, Madeline E. Kavanagh, Dmitrijs Lubriks, Philip Hinchliffe, Gareth W. Langley, Ali F. Aboklaish, Anders Eneroth, Maria Backlund, Andrei G. Baran, Elisabet I. Nielsen, Michael Speake, Janis Kuka, John Robinson, Solveiga Grinberga, Lindsay Robinson, Michael A. McDonough, Anna M. Rydzik, Thomas M. Leissing, Juan Carlos Jimenez-Castellanos, Matthew B. Avison, Solange Da Silva Pinto, Andrew D. Pannifer, Marina Martjuga, Emma Widlake, Martins Priede, Iva Hopkins Navratilova, Marek Gniadkowski, Anna Karin Belfrage, Peter Brandt, Jari Yli-Kauhaluoma, Eric Bacque, Malcolm G. P. Page, Fredrik Björkling, Jonathan M. Tyrrell, James Spencer, Pauline A. Lang, Pawel Baranczewski, Rafael Cantón, Stuart P. McElroy, Philip S. Jones, Fernando Baquero, Edgars Suna, Angus Morrison, Timothy R. Walsh, Christopher J. Schofield

Publikováno v: Brem, J, Panduwawala, T, Hansen, J U, Hewitt, J, Liepins, E, Donets, P, Espina, L, Farley, A J M, Shubin, K, Campillos, G G, Kiuru, P, Shishodia, S, Krahn, D, Leśniak, R K, Schmidt Adrian, J, Calvopiña, K, Turrientes, M-C, Kavanagh, M E, Lubriks, D, Hinchliffe, P, Langley, G W, Aboklaish, A F, Eneroth, A, Backlund, M, Baran, A G, Nielsen, E I, Speake, M, Kuka, J, Robinson, J, Grinberga, S, Robinson, L, McDonough, M A, Rydzik, A M, Leissing, T M, Jimenez-Castellanos, J C, Avison, M B, Da Silva Pinto, S, Pannifer, A D, Martjuga, M, Widlake, E, Priede, M, Hopkins Navratilova, I, Gniadkowski, M, Belfrage, A K, Brandt, P, Yli-Kauhaluoma, J, Bacque, E, Page, M G P, Björkling, F, Tyrrell, J M, Spencer, J, Lang, P A, Baranczewski, P, Cantón, R, McElroy, S P, Jones, P S, Baquero, F, Suna, E, Morrison, A, Walsh, T R & Schofield, C J 2022, ' Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors ', Nature Chemistry, vol. 14, pp. 15-24 . https://doi.org/10.1038/s41557-021-00831-x

Carbapenems are vital antibiotics, but their efficacy is increasingly compromised by metallo-beta-lactamases (MBLs). Here we report the discovery and optimization of potent broad-spectrum MBL inhibitors. A high-throughput screen for NDM-1 inhibitors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b4fafe7a19ff7ed314c37086b73a558
https://research-information.bris.ac.uk/ws/files/323318874/IC_MBLinh_NatChem_accepted.pdf