Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Juan Carlos García Soriano"'
Autor:
Juan Carlos García-Soriano, Héctor de Lucio, Daniel Elvira-Blázquez, Mercedes Alcón-Calderón, Natalia Sanz del Olmo, Pedro A. Sánchez-Murcia, Paula Ortega, Francisco Javier de la Mata, Antonio Jiménez-Ruiz
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
Species of Leishmania and Trypanosoma genera are the causative agents of relevant parasitic diseases. Survival inside their hosts requires the existence of a potent antioxidant enzymatic machinery. Four iron superoxide dismutases have been described
Externí odkaz:
https://doaj.org/article/8b837ee27de94e09b9a3c10679f946f3
Autor:
Alejandro Revuelto, Isabel López-Martín, Héctor de Lucio, Juan Carlos García-Soriano, Nicola Zanda, Sonia de Castro, Federico Gago, Antonio Jiménez-Ruiz, Sonsoles Velázquez, María-José Camarasa
Publikováno v:
Pharmaceuticals, Vol 14, Iss 7, p 689 (2021)
Trypanothione disulfide reductase (TryR) is an essential homodimeric enzyme of trypanosomatid parasites that has been validated as a drug target to fight human infections. Using peptides and peptidomimetics, we previously obtained proof of concept th
Externí odkaz:
https://doaj.org/article/ae16e1932b9142b884536d0bb5ad011f
Autor:
Héctor de Lucio, Alejandro Revuelto, Alejandra A. Carriles, Sonia de Castro, Sonia García-González, Juan Carlos García-Soriano, Mercedes Alcón-Calderón, Pedro A. Sánchez-Murcia, Juan A. Hermoso, Federico Gago, María-José Camarasa, Antonio Jiménez-Ruiz, Sonsoles Velázquez
Publikováno v:
European journal of medicinal chemistry. 244
N-methylation of the triazole moiety present in our recently described triazole-phenyl-thiazole dimerization disruptors of Leishmania infantum trypanothione disulfide reductase (LiTryR) led to a new class of potent in- hibitors that target different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef646e59d43fd7ad91c8810435c36267
https://pubmed.ncbi.nlm.nih.gov/36332553
https://pubmed.ncbi.nlm.nih.gov/36332553
Autor:
Mercedes Alcón-Calderón, Héctor de Lucio, Juan Carlos García-Soriano, Alejandro Revuelto, Sonia de Castro, Celia López-Gutiérrez, Ana San-Félix, Ernesto Quesada, Federico Gago, María-José Camarasa, Antonio Jiménez-Ruiz, Sonsoles Velázquez
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Redox homeostasis in trypanosomatids is based on the low-molecular-weight trypanothione, an essential dithiol molecule that is synthetized by trypanothione synthetase (TryS) and maintained in its reduced state by trypa- nothione disulfide reductase (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffb3a98ac776176e5a689cd192aca99
http://hdl.handle.net/10261/279364
http://hdl.handle.net/10261/279364
Autor:
Carlos Aydillo, Daniel Plano, Carmen Sanmartín, Esther Moreno, Juan Carlos García Soriano, Mikel Etxebeste-Mitxeltorena, Antonio Jiménez-Ruiz, Socorro Espuelas
Publikováno v:
Antimicrob Agents Chemother
This work reports the synthesis and characterization by Fourier transform infrared spectroscopy (FTIR), (1)H, (13)C, and (79)Se nuclear magnetic resonance (NMR), mass spectrometry, and elemental analysis techniques as well as the in vitro evaluation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3112f4a58d5cf6658393585974c7afa
https://doi.org/10.1128/aac.00590-21
https://doi.org/10.1128/aac.00590-21
Autor:
Nicola Zanda, Sonia de Castro, Juan Carlos García-Soriano, Antonio Jiménez-Ruiz, Héctor de Lucio, Federico Gago, Alejandro Revuelto, María-José Camarasa, Isabel López-Martín, Sonsoles Velázquez
Publikováno v:
Pharmaceuticals
Volume 14
Issue 7
Pharmaceuticals, Vol 14, Iss 689, p 689 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Volume 14
Issue 7
Pharmaceuticals, Vol 14, Iss 689, p 689 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Trypanothione disulfide reductase (TryR) is an essential homodimeric enzyme of trypanosomatid parasites that has been validated as a drug target to fight human infections. Using peptides and peptidomimetics, we previously obtained proof of concept th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a9ce634fa455ae08cf88bb33627385
Autor:
Juan Carlos García-Soriano, Antonio Jiménez-Ruiz, Héctor de Lucio, Sonsoles Velázquez, Federico Gago, Alejandro Revuelto, María-José Camarasa, Pedro A. Sánchez-Murcia
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Journal of Medicinal Chemistry
instname
Journal of Medicinal Chemistry
Inhibition of Leishmania infantum trypanothione disulfide reductase (LiTryR) by disruption of its homodimeric interface has proved to be an alternative and unexploited strategy in the search for novel antileishmanial agents. Proof of concept was firs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca5784a0763c514320a850ea5fdb2fc
http://hdl.handle.net/10261/252819
http://hdl.handle.net/10261/252819
Publikováno v:
Dianas. 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19d44a765bd6f132fe17137015aaa71c
https://doi.org/10.37536/dianas.2020.9.1.82
https://doi.org/10.37536/dianas.2020.9.1.82
Publikováno v:
Dianas. 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4e0841c2592fcb116a54656d35b2bb1
https://doi.org/10.37536/dianas.2020.9.1.89
https://doi.org/10.37536/dianas.2020.9.1.89
Autor:
Ramón Alajarín, Juan J. Vaquero, Juan Carlos García-Soriano, Federico Gago, Héctor de Lucio, Javier García-Marín, Miguel A. Toro, Antonio Jiménez-Ruiz, Patricia Sánchez-Alonso
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Fifteen pyridazino-pyrrolo-quinoxalinium salts were synthesized and tested for their antiprotozoal activity against Leishmania infantum amastigotes. Eleven of them turned out to be leishmanicidal, with EC values in the nanomolar range, and displayed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b82360f923704ae2a98e5746ed1068d9
https://doi.org/10.1016/j.ejmech.2021.113915
https://doi.org/10.1016/j.ejmech.2021.113915