Výsledky vyhledávání - "Juan Carlos Drosos-Ramirez"

Akademický článek

Evaluación teórica de las propiedades electrónicas y estructurales que afectan a la conductividad eléctrica en copolímeros de furano-tiofeno

Autor: Jorge Luis Anaya Gil, Juan Carlos Drosos Ramirez, Javier Ernesto Vergara Lorduy, Juan Pablo Toro Rojas, Ricardo Vivas Reyes

Publikováno v: Revista Colombiana de Química, Vol 48, Iss 2, Pp 40-45 (2019)

Desde el punto de vista científico y tecnológico ha habido un gran interés en el uso de monosustituyentes de furano y tiofeno como polímeros conductores, debido a sus múltiples aplicaciones como OLED, amplificadores ópticos, nanotecnología, en

Externí odkaz: https://doaj.org/article/7a59723494b8472ebf297c192344d59a

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G-score: A function to solve the puzzle of modeling the protonation states of β-secretase binding pocket

Autor: Carlos Gueto-Tettay, Luis Pelaez-Bedoya, Alejandro Martinez-Consuegra, Juan Carlos Drosos-Ramirez

Publikováno v: Journal of Molecular Graphics and Modelling. 85:1-12

The population density concept has emerged as a proposal for the analysis of molecular dynamics results, the key characteristic of population density is the evaluation of the simultaneous occurrence of a set of relevant parameters for a system. Howev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bca36c707b50217a039fdcf764ec0b61
https://doi.org/10.1016/j.jmgm.2018.07.008

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Population density analysis for determining the protonation state of the catalytic dyad in BACE1-tertiary carbinamine-based inhibitor complex

Autor: Luis Pelaez-Bedoya, Juan Carlos Drosos-Ramirez, Carlos Gueto-Tettay

Publikováno v: Journal of Biomolecular Structure and Dynamics. 36:3557-3574

BACE1 is an aspartyl protease with a very relevant role in medicinal chemistry related to Alzheimer Disease since it has demonstrated to be a promising therapeutic target for inhibition and possible control for the progress of the peptide accumulatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2053ccb16517561dd032f9681fa35a46
https://doi.org/10.1080/07391102.2017.1393461

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Theoretical evaluation of the electronic and structural properties that affect the electrical conductivity in furan-thiophene copolymers

Autor: Juan Carlos Drosos Ramirez, Juan Pablo Toro Rojas, Javier Vergara Lorduy, Ricardo Vivas Reyes, Jorge Luis Anaya Gil

Publikováno v: Revista Colombiana de Química, Volume: 48, Issue: 2, Pages: 40-45, Published: 26 JUN 2019
Revista Colombiana de Química, Vol 48, Iss 2, Pp 40-45 (2019)

Resumen Desde el punto de vista científico y tecnológico ha habido un gran interés en el uso de monosustituyentes de furano y tiofeno como polímeros conductores, debido a sus múltiples aplicaciones como OLED, amplificadores ópticos, nanotecnolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4544f41b404799703ca80e8ce6096f
http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-28042019000200040&lng=en&tlng=en

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Determination of the protonation state for the catalytic dyad in β-secretase when bound to hydroxyethylamine transition state analogue inhibitors: A molecular dynamics simulation study

Autor: Juan Carlos Drosos-Ramirez, Roberto Pestana-Nobles, Carlos Gueto-Tettay

Publikováno v: Journal of Molecular Graphics and Modelling. 66:155-167

BACE1 is an aspartyl protease of pharmacological interest for its direct participation in Alzheimer's disease (AD) through β-amyloid peptide production. Two aspartic acid residues are present in the BACE1 catalytic region which can adopt multiple pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bda6852149fbfacb29d83ce10c0dbb8
https://doi.org/10.1016/j.jmgm.2016.04.003

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A PM7 dynamic residue-ligand interactions energy landscape of the BACE1 inhibitory pathway by hydroxyethylamine compounds. Part I: The flap closure process

Autor: Alejandro Martinez-Consuegra, Joshua Zuchniarz, Carlos Gueto-Tettay, Luis Roberto Gueto-Tettay, Juan Carlos Drosos-Ramirez

Publikováno v: Journal of molecular graphicsmodelling. 76

BACE1 is an enzyme of scientific interest because it participates in the progression of Alzheimer’s disease. Hydroxyethylamines (HEAs) are a family of compounds which exhibit inhibitory activity toward BACE1 at a nanomolar level, favorable pharmaco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4530de30828fd6003300afceb57210e
https://pubmed.ncbi.nlm.nih.gov/28746905

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A molecular dynamics study of the BACE1 conformational change from Apo to closed form induced by hydroxyethylamine derived compounds

Autor: Yeyson Fortich-Seca, Carlos Gueto-Tettay, Joshua Zuchniarz, Luis Roberto Gueto-Tettay, Juan Carlos Drosos-Ramirez

Publikováno v: Journal of molecular graphicsmodelling. 70

BACE1 is an aspartyl protease which is a therapeutic target for Alzheimer's disease (AD) because of its participation in the rate-limiting step in the production of Aβ-peptide, the accumulation of which produces senile plaques and, in turn, the neur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6379cabce180cf27d5725c5944e8395
https://pubmed.ncbi.nlm.nih.gov/27750187

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