Výsledky vyhledávání - "Juan Carlos Amat"

Four-channel asymmetric Real-Time PCR hybridization probe assay: A rapid pre-screening method for critical BCR-ABL kinase domain mutations

Autor: Jordi Martinez-Serra, Carmen Ballester, Carmen Vidal, Josep Miquel Bauça, Sara SanFelix, Joan Besalduch, Teresa Bex, Juan Carlos Amat, Simona Soverini, Carmen Santos, Toni F. Marcús, Andrés Novo, Antonio Gutierrez, María Navarro-Palou, Teresa Ros

Publikováno v: Clinical Biochemistry. 45:345-351

Objectives Within the laboratory protocols, used for the study of BCR-ABL resistance mutations in chronic myeloid leukemia patients treated with Imatinib, direct sequencing remains the reference method. Since the incidence of patients with a mutation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21075cd18bf12e3b30dddababcc1fd07
https://doi.org/10.1016/j.clinbiochem.2011.12.026

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Yondelis® (ET-743, Trabectedin) sensitizes cancer cell lines to CD95-mediated cell death: New molecular insight into the mechanism of action

Autor: Carlos Saus, Antonio Gutierrez, Joan Besalduch, Joana M. Plazas, Rafael Ramos, Elena Maffiotte, Matias Diaz, Jordi Gines, Juan Carlos Amat, María Navarro-Palou, Jordi Martinez-Serra, Oliver Vögler, Regina Alemany, Teresa Ros, Teresa Bex, Javier Martín

Publikováno v: European Journal of Pharmacology. 658:57-64

Trabectedin, a naturally occurring substance isolated from the Caribbean marine invertebrate Ecteinascidia turbinata, is the active compound of the antitumor drug Yondelis®. The mechanism of action of Trabectedin has been attributed to interactions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::621ae3275a8a3ad3038f6724b55231d4
https://doi.org/10.1016/j.ejphar.2011.02.035

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Prognostic value of serum CA125 levels in diffuse large B-cell lymphoma: potential role of a new sex- and age-adjusted reference value

Autor: Jordi Martinez-Serra, Bernardino Barceló, Juan Besalduch, Rafael Yus Ramos, Antonia Sampol, Maria Dolores Bea, Juan Carlos Amat, Jose A. Rodriguez, Antonia Bautista, L. Viñas, J. Forteza-Rey, Guillermo A. González, Antonio Gutierrez, J. P. Martin

Publikováno v: International Journal of Laboratory Hematology. 32:582-589

Summary CA125, a tumor marker normally used to follow the clinical course of ovarian cancer, also may have a role in lymphoma. All available series were analyzed using the standard reference value 35 U/ml, but age and sex may influence serum CA125 (s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1faff788c1a7d6f59da05e8350deef13
https://doi.org/10.1111/j.1751-553x.2010.01225.x

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Inhibition of c-Myc Down-Regulation by Sustained Extracellular Signal-Regulated Kinase Activation Prevents the Antimetabolite Methotrexate- and Gemcitabine-Induced Differentiation in Non-Small-Cell Lung Cancer Cells

Autor: Joan Besalduch, Antonio Galmés, Jordi Gines, Antonia Sampol, Javier Martin, Jordi M. Serra, Lorenzo Serra-Moisés, Antonio Gutierrez, María A. Navarro, Carlos Saus, Juan Carlos Amat, Oliver Vögler, Regina Alemany, Teresa Ros

Publikováno v: Molecular Pharmacology. 73:1679-1687

Non-small-cell lung cancer (NSCLC) is characterized by severe resistance to chemotherapy. Here, we demonstrate that A549 adenocarcinoma cells permanently differentiate with the antimetabolites methotrexate (MTX) and gemcitabine (GE) when blocking the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c6474ca64a93603382b2dd42a5345c
https://doi.org/10.1124/mol.107.043372

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Fluorescence resonance energy transfer-based real-time polymerase chain reaction method without DNA extraction for the genotyping of F5, F2, F12, MTHFR, and HFE

Autor: Antonio Gutierrez, Joan Besalduch, Jordi Martinez-Serra, Oliver Vögler, Aina Abelló, Aina Noguera, Antoni Nicolàs, Juan Robles, Regina Alemany, Teresa Ros, Juan Carlos Amat

Publikováno v: Journal of Blood Medicine

Jordi Martinez-Serra,1 Juan Robles,2 Antoni Nicolàs,3 Antonio Gutierrez,1 Teresa Ros,1 Juan Carlos Amat,1 Regina Alemany,4 Oliver Vögler,4 Aina Abelló,2 Aina Noguera,2 Joan Besalduch1 1Department of Hematology, 2Department of Clinical Analysis, Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4282ca60173289595fa168f985b8ae
https://pubmed.ncbi.nlm.nih.gov/25028568

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Chronic myeloid leukemia with an e1a3 BCR-ABL fusion protein: transformation to lymphoid blast crisis

Autor: Izabela Orlinska, Antonio Gutierrez, Juan Carlos Amat, Maria Antonia Duran, Raquel Del Campo, Joan Besalduch, Leyre Bento, Magdalena Ginard, Jordi Martinez-Serra, Julio Iglesias, Carmen Vidal, Jose Luis Antich, Teresa Ros

Publikováno v: Biomarker Research

Chronic myelogenous leukemia (CML) results from the neoplastic transformation of a hematopoietic stem cell. CML is cytogenetically characterized by the presence of the Philadelphia chromosome (Ph’). Most patients with CML express e13a2 or e14a2 mRN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37209376e230b3e3ae35cef1bd289d54
https://doi.org/10.1186/2050-7771-2-14

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New real-time PCR-based method for the joint genotyping of JAK2 (V617F) with inherited thrombophilic F5 and F2 mutations

Autor: Jordi Martinez-Serra, Maria Antonia Duran, E. Maffiotte, Juan Besalduch, A. Gutierrez, Juan Carlos Amat

Publikováno v: Clinica chimica acta; international journal of clinical chemistry. 410(1-2)

Background During the last years the appearance of the acquired V617F mutation of the Janus Kinase 2 gene (JAK2) in patients suffering different thrombotic events has been described. We decided to develop a new and rapid multiplex real-time Polymeras

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f298cc82e77a8c2f05472751965c97
https://pubmed.ncbi.nlm.nih.gov/19778528

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NK and T-Cell Status as Well as Their Perforin Expression Is Related to Clinical Severity and Outcome in Difuse Large Cell Lymphoma

Autor: Roberto Villavicencio, Oliver Voegler, Jordi Martínez, Joan Besalduch, Antonia Bautista, Maria Antonia Duran, Carmen Ballester, Juan Carlos Amat, Maria Dolores Bea, Jose A. Rodriguez, Antonia Sampol, Cristina Linares, Julio Rifa, Miguel Morey, Antonio Gutierrez, Regina Alemany, Catalina Crespi

Publikováno v: Blood. 110:1574-1574

A variable degree of immune impairment is present in lymphomas, either as a cause or a consequence of the disease. There is preliminary evidence that this immune status is related to disease control and survival. Our objective was to analyze the rela

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec240482022f3e899300c5c8246a0357
https://doi.org/10.1182/blood.v110.11.1574.1574

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