Výsledky vyhledávání - "Juan Carlos Aledo"

Akademický článek

Phylogenies from unaligned proteomes using sequence environments of amino acid residues

Autor: Juan Carlos Aledo

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)

Abstract Alignment-free methods for sequence comparison and phylogeny inference have attracted a great deal of attention in recent years. Several algorithms have been implemented in diverse software packages. Despite the great number of existing meth

Externí odkaz: https://doaj.org/article/08c8ecb7884e4a5a9a932303cf230baf

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Akademický článek

renz: An R package for the analysis of enzyme kinetic data

Autor: Juan Carlos Aledo

Publikováno v: BMC Bioinformatics, Vol 23, Iss 1, Pp 1-10 (2022)

Abstract Background Complex enzymatic models are required for analyzing kinetic data derived under conditions that may not satisfy the assumptions associated with Michaelis–Menten kinetics. To analyze these data, several software packages have been

Externí odkaz: https://doaj.org/article/661dde36d57040b995f7370c3f525d84

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Akademický článek

Proteome-Wide Structural Computations Provide Insights into Empirical Amino Acid Substitution Matrices

Autor: Pablo Aledo, Juan Carlos Aledo

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 1, p 796 (2023)

The relative contribution of mutation and selection to the amino acid substitution rates observed in empirical matrices is unclear. Herein, we present a neutral continuous fitness-stability model, inspired by the Arrhenius law (qij=aije−ΔΔGij). T

Externí odkaz: https://doaj.org/article/5ef76ec2aea4452cae9b9b0b624f776c

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Akademický článek

A Census of Human Methionine-Rich Prion-like Domain-Containing Proteins

Autor: Juan Carlos Aledo

Publikováno v: Antioxidants, Vol 11, Iss 7, p 1289 (2022)

Methionine-rich prion-like proteins can regulate liquid–liquid phase separation processes in response to stresses. To date, however, very few proteins have been identified as methionine-rich prion-like. Herein, we have performed a computational sur

Externí odkaz: https://doaj.org/article/fc09c4c13dca4fc8abbd0f4dac335ac2

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Akademický článek

The Role of Methionine Residues in the Regulation of Liquid-Liquid Phase Separation

Autor: Juan Carlos Aledo

Publikováno v: Biomolecules, Vol 11, Iss 8, p 1248 (2021)

Membraneless organelles are non-stoichiometric supramolecular structures in the micron scale. These structures can be quickly assembled/disassembled in a regulated fashion in response to specific stimuli. Membraneless organelles contribute to the spa

Externí odkaz: https://doaj.org/article/0f30fafc22f34422ba0a00cee1ff2a98

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Akademický článek

Inferring Methionine Sulfoxidation and serine Phosphorylation crosstalk from Phylogenetic analyses

Autor: Juan Carlos Aledo

Publikováno v: BMC Evolutionary Biology, Vol 17, Iss 1, Pp 1-13 (2017)

Abstract Background The sulfoxidation of methionine residues within the phosphorylation motif of protein kinase substrates, may provide a mechanism to couple oxidative signals to changes in protein phosphorylation. Herein, we hypothesize that if the

Externí odkaz: https://doaj.org/article/771c2e5cd6f248bd9886e985382e485d

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