Zobrazeno 1 - 10
of 428
pro vyhledávání: '"Juan C. Troncoso"'
Autor:
Rogger P. Carmen-Orozco, William Tsao, Yingzhi Ye, Irika R. Sinha, Koping Chang, Vickie T. Trinh, William Chung, Kyra Bowden, Juan C. Troncoso, Seth Blackshaw, Lindsey R. Hayes, Shuying Sun, Philip C. Wong, Jonathan P. Ling
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-17 (2024)
Abstract Background Cytoplasmic inclusions and loss of nuclear TDP-43 are key pathological features found in several neurodegenerative disorders, suggesting both gain- and loss-of-function mechanisms of disease. To study gain-of-function, TDP-43 over
Externí odkaz:
https://doaj.org/article/57aa4877bd6841eeb1d7825c31059ce8
Autor:
Przemysław R. Kac, Fernando González-Ortiz, Andreja Emeršič, Maciej Dulewicz, Srinivas Koutarapu, Michael Turton, Yang An, Denis Smirnov, Agnieszka Kulczyńska-Przybik, Vijay R. Varma, Nicholas J. Ashton, Laia Montoliu-Gaya, Elena Camporesi, Izabela Winkel, Bogusław Paradowski, Abhay Moghekar, Juan C. Troncoso, Tammaryn Lashley, Gunnar Brinkmalm, Susan M. Resnick, Barbara Mroczko, Hlin Kvartsberg, Milica Gregorič Kramberger, Jörg Hanrieder, Saša Čučnik, Peter Harrison, Henrik Zetterberg, Piotr Lewczuk, Madhav Thambisetty, Uroš Rot, Douglas Galasko, Kaj Blennow, Thomas K. Karikari
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Blood phosphorylated tau (p-tau) biomarkers, including p-tau217, show high associations with Alzheimer’s disease (AD) neuropathologic change and clinical stage. Certain plasma p-tau217 assays recognize tau forms phosphorylated additionally
Externí odkaz:
https://doaj.org/article/cd9a96562fae4bf787bc8b6e650f5603
Autor:
Paolo Reho, Sara Saez-Atienzar, Paola Ruffo, Sultana Solaiman, Zalak Shah, Ruth Chia, Karri Kaivola, Bryan J. Traynor, Bension S. Tilley, Steve M. Gentleman, Angela K. Hodges, Dag Aarsland, Edwin S. Monuki, Kathy L. Newell, Randy Woltjer, Marilyn S. Albert, Ted M. Dawson, Liana S. Rosenthal, Juan C. Troncoso, Olga Pletnikova, Geidy E. Serrano, Thomas G. Beach, Hariharan P. Easwaran, Sonja W. Scholz
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Dementia with Lewy bodies (DLB) is a common form of dementia in the elderly population. We performed genome-wide DNA methylation mapping of cerebellar tissue from pathologically confirmed DLB cases and controls to study the epigenetic profil
Externí odkaz:
https://doaj.org/article/1f5a47a3a95d4835830f83e30874d417
Autor:
Chan Chen, Ramhari Kumbhar, Hu Wang, Xiuli Yang, Kundlik Gadhave, Cyrus Rastegar, Yasuyoshi Kimura, Adam Behensky, Sumasri Kotha, Grace Kuo, Sruthi Katakam, Deok Jeong, Liang Wang, Anthony Wang, Rong Chen, Shu Zhang, Lingtao Jin, Creg J. Workman, Dario A. A. Vignali, Olga Pletinkova, Hongpeng Jia, Weiyi Peng, David W. Nauen, Philip C. Wong, Javier Redding‐Ochoa, Juan C. Troncoso, Mingyao Ying, Valina L. Dawson, Ted M. Dawson, Xiaobo Mao
Publikováno v:
Advanced Science, Vol 11, Iss 16, Pp n/a-n/a (2024)
Abstract The spread of prion‐like protein aggregates is a common driver of pathogenesis in various neurodegenerative diseases, including Alzheimer's disease (AD) and related Tauopathies. Tau pathologies exhibit a clear progressive spreading pattern
Externí odkaz:
https://doaj.org/article/145c90cce75b4410b097bed388733661
Autor:
Mariyam Humayun, Lucy Zhang, Thomas D. Zaikos, Nivedha Kannapadi, Jose I. Suarez, David N. Hager, Juan C. Troncoso, Sung-Min Cho
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
Acute brain injury (ABI) and neuroinflammation is reported in COVID-19 and acute respiratory distress syndrome (ARDS). It remains unclear if COVID-19 plays an independent role in development of ABI compared to those with non-COVID-19 ARDS. We aimed t
Externí odkaz:
https://doaj.org/article/6c8e1776ed9c42ebb43dfa1a7d3cfed6
Autor:
Yiyao Huang, Tanina Arab, Ashley E. Russell, Emily R. Mallick, Rajini Nagaraj, Evan Gizzie, Javier Redding‐Ochoa, Juan C. Troncoso, Olga Pletnikova, Andrey Turchinovich, David A. Routenberg, Kenneth W. Witwer
Publikováno v:
Interdisciplinary Medicine, Vol 1, Iss 4, Pp n/a-n/a (2023)
Abstract Extracellular vesicles (EVs) are released from different cell types in the central nervous system (CNS) and play roles in regulating physiological and pathological functions. Although brain‐derived EVs (bdEVs) have been successfully collec
Externí odkaz:
https://doaj.org/article/1f8dd20d4e9c4d5cbb2131ee404424d1
Publikováno v:
Autopsy and Case Reports, Vol 13 (2023)
Internal watershed infarcts (IWIs) occur at the junction of the deep and superficial perforating arterial branches of the cerebrum. Despite documentation in the radiology literature, IWIs are rarely encountered at the time of autopsy. Here, we report
Externí odkaz:
https://doaj.org/article/b1b9983322f14ee08811c5238e794d8a
Autor:
Dong Won Kim, Kevin J. Tu, Alice Wei, Ashley J. Lau, Anabel Gonzalez-Gil, Tianyu Cao, Kerstin Braunstein, Jonathan P. Ling, Juan C. Troncoso, Philip C. Wong, Seth Blackshaw, Ronald L. Schnaar, Tong Li
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-23 (2022)
Abstract Background Amongst risk alleles associated with late-onset Alzheimer’s disease (AD), those that converged on the regulation of microglia activity have emerged as central to disease progression. Yet, how canonical amyloid-β (Aβ) and tau p
Externí odkaz:
https://doaj.org/article/ec442a6e4b7a4771a917c198f063d4ef
Autor:
Yura Jang, Thujitha Thuraisamy, Javier Redding‐Ochoa, Olga Pletnikova, Juan C. Troncoso, Zhen Zhang, Liana S. Rosenthal, Ted M. Dawson, Alexander Y. Pantelyat, Chan Hyun Na
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 11, Pp n/a-n/a (2022)
Abstract Background Progressive supranuclear palsy (PSP) is a neurodegenerative disorder clinically characterized by progressive postural instability, supranuclear gaze palsy, parkinsonism, and cognitive decline caused by degeneration in specific are
Externí odkaz:
https://doaj.org/article/5e0d29f74f0049ad92e603b339602920
Autor:
Vijay R. Varma, H. Büşra Lüleci, Anup M. Oommen, Sudhir Varma, Chad T. Blackshear, Michael E. Griswold, Yang An, Jackson A. Roberts, Richard O’Brien, Olga Pletnikova, Juan C. Troncoso, David A. Bennett, Tunahan Çakır, Cristina Legido-Quigley, Madhav Thambisetty
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 7, Iss 1, Pp 1-14 (2021)
Abstract The role of brain cholesterol metabolism in Alzheimer’s disease (AD) remains unclear. Peripheral and brain cholesterol levels are largely independent due to the impermeability of the blood brain barrier (BBB), highlighting the importance o
Externí odkaz:
https://doaj.org/article/9b5faa98d6754c758ecbe26dd59288c8