Microglial targeted therapy relieves cognitive impairment caused by Cntnap4 deficiency

Autor: Wenlong Zhang, Huaqing Chen, Liuyan Ding, Jie Huang, Mengran Zhang, Yan Liu, Runfang Ma, Shaohui Zheng, Junwei Gong, Juan C. Piña‐Crespo, Yunlong Zhang

Publikováno v: Exploration, Vol 3, Iss 3, Pp n/a-n/a (2023)

Abstract Contactin‐associated protein‐like 4 (Cntnap4) is critical for GABAergic transmission in the brain. Impaired Cntnap4 function is implicated in neurological disorders, such as autism; however, the role of Cntnap4 on memory processing is po

Externí odkaz: https://doaj.org/article/455e5addb6bb436c9dd620117d03a645

Acute Ethanol Exposure Enhances Synaptic Plasticity in the Dorsal Striatum in Adult Male and Female Rats

Autor: John J. Woodward, Yosef Avchalumov, Chitra D. Mandyam, Juan C. Piña-Crespo

Publikováno v: Brain Plasticity

Background: Acute (ex vivo) and chronic (in vivo) alcohol exposure induces neuroplastic changes in the dorsal striatum, a critical region implicated in instrumental learning. Objective: Sex differences are evident in alcohol reward and reinforcement,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d5f8c533f79fee4af7c096ba6d4fa4
http://europepmc.org/articles/PMC7903017

Sexually dimorphic prelimbic cortex mechanisms play a role in alcohol dependence: protection by endostatin

Autor: Wulfran Trenet, Nancy Xing, Britta D. Sibley, Sucharita S. Somkuwar, Sumaiya Olia, Alison D. Kreisler, Juan C. Piña-Crespo, Jacob R Watson, Chitra D. Mandyam, Yosef Avchalumov, Tejash Bharadwaj, Marisa Roberto, Amin A Shayan

Publikováno v: Neuropsychopharmacology

Angiogenesis or proliferation of endothelial cells plays a role in brain microenvironment homeostasis. Previously we have shown enhanced expression of markers of angiogenesis in the medial prefrontal cortex during abstinence in an animal model of eth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::664e7a5aa60c2f14fee02da8afc75e20
https://europepmc.org/articles/PMC8429630/

α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss

Autor: Swagata Ghatak, Maria Talantova, Sara Sanz-Blasco, Mohd Waseem Akhtar, Jeffery W. Kelly, Stuart A. Lipton, William P. Lynch, Dorit Trudler, Juan C. Piña-Crespo, Karthik Bodhinathan, Yvonne S. Eisele

Publikováno v: J Neurosci

Synaptic and neuronal loss are major neuropathological characteristics of Parkinson's disease. Misfolded protein aggregates in the form of Lewy bodies, comprised mainly of α-synuclein (αSyn), are associated with disease progression, and have also b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d04f7556e99abdc9d37a9b1cbb4a39
https://pubmed.ncbi.nlm.nih.gov/33483428

Caveolin-1 Expression in the Dorsal Striatum Drives Methamphetamine Addiction-Like Behavior

Autor: Brian P. Head, Wulfran Trenet, Yosef Avchalumov, Alison D. Kreisler, Juan C. Piña-Crespo, Chitra D. Mandyam, Mahasweta Nayak

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 8219, p 8219 (2021)
International journal of molecular sciences, vol 22, iss 15
International Journal of Molecular Sciences
Volume 22
Issue 15

Dopamine D1 receptor (D1R) function is regulated by membrane/lipid raft-resident protein caveolin-1 (Cav1). We examined whether altered expression of Cav1 in the dorsal striatum would affect self-administration of methamphetamine, an indirect agonist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec7b8b59bdfda88fffbd0a2d041a39ae
https://doi.org/10.3390/ijms22158219