Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Juan C. Fontecilla-Camps"'
Autor:
Jason C. Crack, Patricia Amara, Eve de Rosny, Claudine Darnault, Melanie R. Stapleton, Jeffrey Green, Anne Volbeda, Juan C. Fontecilla-Camps, Nick E. Le Brun
Publikováno v:
Inorganics, Vol 11, Iss 12, p 450 (2023)
The Escherichia coli fumarate and nitrate reduction (FNR) regulator acts as the cell’s master switch for the transition between anaerobic and aerobic respiration, controlling the expression of >300 genes in response to O2 availability. Oxygen is pe
Externí odkaz:
https://doaj.org/article/7626079ad8894802abd31312e1cfe935
Autor:
Roman Rohac, Jason C. Crack, Eve de Rosny, Océane Gigarel, Nick E. Le Brun, Juan C. Fontecilla-Camps, Anne Volbeda
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
The crystal structure of the iron-sulfur protein NsrR from Streptomyces coelicolor bound to a gene operator fragment is reported and compared with other structures, giving insight into the structural determinants of DNA recognition by the NO sensor.
Externí odkaz:
https://doaj.org/article/b3514387f0f54ce683145e5562306895
Autor:
Mickaël V. Cherrier, Xavier Vernède, Daphna Fenel, Lydie Martin, Benoit Arragain, Emmanuelle Neumann, Juan C. Fontecilla-Camps, Guy Schoehn, Yvain Nicolet
Publikováno v:
Biomolecules, Vol 12, Iss 3, p 441 (2022)
Metalloproteins are involved in key cell processes such as photosynthesis, respiration, and oxygen transport. However, the presence of transition metals (notably iron as a component of [Fe-S] clusters) often makes these proteins sensitive to oxygen-i
Externí odkaz:
https://doaj.org/article/05ce7557a27e4bf797cb124b44be0a08
Autor:
Anne Volbeda, Erin L. Dodd, Claudine Darnault, Jason C. Crack, Oriane Renoux, Matthew I. Hutchings, Nick E. Le Brun, Juan C. Fontecilla-Camps
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
NsrR is a bacterial transcriptional regulator that acts as a nitric oxide (NO) sensor. Here, the authors present the crystal structure of NsrR, which reveals an unusual Fe-S cluster coordination and explains how NO exposure leads to the degradation o
Externí odkaz:
https://doaj.org/article/d75fcbfde85945c6bdbb68596b935661
Autor:
Christine Hajjar, Mickaël V. Cherrier, Gaëtan Dias Mirandela, Isabelle Petit-Hartlein, Marie José Stasia, Juan C. Fontecilla-Camps, Franck Fieschi, Jérôme Dupuy
Publikováno v:
mBio, Vol 8, Iss 6 (2017)
ABSTRACT Transmembrane NADPH oxidase (NOX) enzymes have been so far only characterized in eukaryotes. In most of these organisms, they reduce molecular oxygen to superoxide and, depending on the presence of additional domains, are called NOX or dual
Externí odkaz:
https://doaj.org/article/6cb90c7e1136436e82aedc8d6d255758
Autor:
Juan C. Fontecilla-Camps
Publikováno v:
Life, Vol 4, Iss 4, Pp 1013-1025 (2014)
Spark-tube experiments and analysis of meteorite contents have led to the widespread notion that abiotic organic molecules were the first life components. However, there is a contradiction between the abundance of simple molecules, such as the amino
Externí odkaz:
https://doaj.org/article/7bc3a730a09f4d5fa995777dfb649534
Autor:
Juan C. Fontecilla‐Camps
Publikováno v:
ChemBioChem
ChemBioChem, 2023, pp.e202300048. ⟨10.1002/cbic.202300048⟩
ChemBioChem, 2023, pp.e202300048. ⟨10.1002/cbic.202300048⟩
International audience; Examination of the genetic code (GeCo) reveals that amino acids coded by (A/U) codons display a large functional spectrum and bind RNA whereas, except for Arg, those coded by (G/C) codons do not. From a stereochemical viewpoin
Autor:
Juan C. Fontecilla-Camps, Anne Volbeda
Publikováno v:
Chemical Reviews
Chemical Reviews, 2022, ⟨10.1021/acs.chemrev.1c00869⟩
Chemical Reviews, 2022, ⟨10.1021/acs.chemrev.1c00869⟩
International audience; The activation energy barrier of biochemical reactions is normally lowered by an enzyme catalyst, which directly helps the weakening of the bond(s) to be broken. In many metalloenzymes, this is a first coordination sphere effe
Autor:
Juan C. Fontecilla‐Camps
Publikováno v:
ChemBioChem
ChemBioChem, 2022, 2022, pp.e202200064. ⟨10.1002/cbic.202200064⟩
ChemBioChem, 2022, 2022, pp.e202200064. ⟨10.1002/cbic.202200064⟩
International audience; ATP is generally defined as the "energy currency" of the cell. Its phosphoanhydride P-O bonds are often considered to be "high energy" linkages that release free energy when broken, and its hydrolysis is described as "strongly
Publikováno v:
Encyclopedia of Inorganic and Bioinorganic Chemistry
Encyclopedia of Inorganic and Bioinorganic Chemistry, 1, Wiley Online Library, 2020, 9781119951438. ⟨10.1002/9781119951438.eibc2704⟩
Encyclopedia of Inorganic and Bioinorganic Chemistry, 1, Wiley Online Library, 2020, 9781119951438. ⟨10.1002/9781119951438.eibc2704⟩
International audience; Protein-coordinated iron–sulfur clusters play multiple crucial functions in biological processes. One of these functions is the response to effectors that regulate gene expression. This response can be very variable. Several