Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Juan C. de la Rosa"'
Autor:
Elena Sandoval, Maria Santos Martinez-Martinez, Beatriz Hernández Díaz, Esther Fernández, Maria Jose Lafuente-Monasterio, Jeremy N. Burrows, Simon J. F. Macdonald, Sara Prats, John N. Haselden, Gerard Drewes, Pablo Castañeda, Francisco J. Gamo, J. Vidal, Jose Ignacio Martin Hernando, Benigno Crespo, Margarita Puente, David Matthew Wilson, Paul Bamborough, María Luisa León, Maria Jesus Almela, Sonja Ghidelli-Disse, Rubén M. Gómez, Jaime de Mercado, Carolyn Selenski, Jose M. Coteron, Anne Rodríguez, Cristina de Cozar, Michael J Witty, Juan C. de la Rosa, Paul Willis, Iñigo Angulo-Barturen, María J. Chaparro, Lourdes Rueda, Félix Calderón, Nicholas Cammack, Santiago Ferrer-Bazaga, Sophie Huss, María T. Fraile, María Belén Jiménez Díaz
Publikováno v:
Journal of Medicinal Chemistry. 60:6880-6896
Since the appearance of resistance to the current front-line antimalarial treatments, ACTs (artemisinin combination therapies), the discovery of novel chemical entities to treat the disease is recognized as a major global health priority. From the GS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acfce1c3bf707c62527d304e5e25cb21
https://doi.org/10.1021/acs.jmedchem.6b01441
https://doi.org/10.1021/acs.jmedchem.6b01441
Autor:
María Luisa León, Esperanza Herreros, Santiago Ferrer, Jeremy N. Burrows, Félix Calderón, Milagros Lorenzo, Adolfo García-Pérez, Jorge Fernández, Beatriz Hernández Díaz, María T. Fraile, Iñigo Angulo-Barturen, Jesús Chicharro, Jose M. Fiandor, Juan C. de la Rosa, Mercedes García, Anas Saadeddin, Margarita Puente, Jose M. Bueno, Araceli Mallo
Publikováno v:
Journal of medicinal chemistry. 61(8)
Malaria is still one of the most prevalent parasitic infections in the world, with half of the world's population at risk for malaria. The effectiveness of current antimalarial therapies, even that of the most recent class of antimalarial drugs (arte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3440fda70b393d49dfa59715f5b0016b
https://pubmed.ncbi.nlm.nih.gov/29589932
https://pubmed.ncbi.nlm.nih.gov/29589932
Autor:
Paul Willis, Elena Sandoval, Carolyn Selenski, Michael J Witty, Maria Jesus Almela, Jaime de Mercado, Sonja Ghidelli-Disse, Jeremy N. Burrows, Simon J. F. Macdonald, Anne Rodríguez, Santiago Ferrer-Bazaga, Cristina de Cozar, Beatriz Hernández Díaz, Paul Bamborough, Sara Prats, Rubén M. Gómez, María Belén Jiménez Díaz, Maria Jose Lafuente-Monasterio, Iñigo Angulo-Barturen, Margarita Puente, David M. Wilson, Jose M. Coteron, Juan C. de la Rosa, Pablo Castañeda, María Luisa León, Francisco J. Gamo, Jose Ignacio Martin Hernando, John N. Haselden, María J. Chaparro, Sophie Huss, María T. Fraile, Lourdes Rueda, Félix Calderón, Nicholas Cammack, Maria Santos Martinez-Martinez, Gerard Drewes, J. Vidal, Benigno Crespo, Esther Fernández
Publikováno v:
Journal of medicinal chemistry. 60(23)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca0175d454f38a34fcaa02c5eae30f5
https://pubmed.ncbi.nlm.nih.gov/28806082
https://pubmed.ncbi.nlm.nih.gov/28806082
Akademický článek
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Autor:
Sara Prats, Jorge Solana, Esther Fernández, Félix Calderón, Francisco-Javier Gamo, Jeremy N. Burrows, Teresa Mulet, Michael J Witty, Jaume Vidal-Mas, Juan C. de la Rosa, María Belén Jiménez-Díaz
Publikováno v:
ACS Medicinal Chemistry Letters. 3:373-377
From the 13 533 chemical structures published by GlaxoSmithKline in 2010, we identified 47 quality starting points for lead optimization. One of the most promising hits was the TCMDC-139046, a molecule presenting an indoline core, which is well-known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee45f1de28bb414475339d15f5903c4a
https://doi.org/10.1021/ml300008j
https://doi.org/10.1021/ml300008j
Autor:
Mariola Gordo, Elena Sandoval, Jose M. Coteron, Jiri Gut, Beatriz Hernández Díaz, María J. Chaparro, Jennifer Legac, Santiago Ferrer, David Catterick, Julia Castro, Juan Miguel, Maria L. Marco, Pilar Ventosa, Philip J. Rosenthal, Vicente Muñoz, Jose M. Fiandor, José Ruiz, Juan C. de la Rosa, Francisco J. Gamo, Esther Porras, Esther Fernández, Laura Fernández de las Heras
Publikováno v:
Journal of Medicinal Chemistry. 53:6129-6152
Falcipain-2 and falcipain-3 are papain-family cysteine proteases of the malaria parasite Plasmodium falciparum that are responsible for host hemoglobin hydrolysis to provide amino acids for parasite protein synthesis. Different heteroarylnitrile deri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26636cd9e1d7aaed39cee9baeb817bce
https://doi.org/10.1021/jm100556b
https://doi.org/10.1021/jm100556b
Autor:
Mariola Gordo, María J. Chaparro, María Belén Jiménez-Díaz, Esther Fernández, María Santos Martínez, Albane Kessler, Isabel Castellote, Francisco-Javier Gamo, Lourdes Rueda, Adolfo García-Pérez, Juan C. de la Rosa, Laura M. Sanz, Julia Castro-Pichel, Simon J. F. Macdonald
Publikováno v:
ACS medicinal chemistry letters. 2(11)
Rapid triaging of three series of related hits selected from the Tres Cantos Anti-Malarial Set (TCAMS) are described. A triazolopyrimidine series was deprioritized due to delayed inhibition of parasite growth. A lactic acid series has derivatives wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::357f36d32318de14c47a9c6d4bf33f16
https://pubmed.ncbi.nlm.nih.gov/24900273
https://pubmed.ncbi.nlm.nih.gov/24900273
Autor:
Beatriz Hernández Díaz, Esther Porras, Esther Fernández, José Ruiz, María J. Chaparro, Francisco J. Gamo, Julia Castro, Elena Sandoval, Juan C. de la Rosa, Jose M. Fiandor, Laura Fernández de las Heras, Jiri Gut, Jennifer Legac, David Catterick, Mariola Gordo, Jose M. Coteron, Santiago Ferrer, Philip J. Rosenthal, Maria L. Marco, Juan Miguel, Vicente Muñoz, Pilar Ventosa
Publikováno v:
Journal of Medicinal Chemistry. 53:7885-7886
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78e0b88e8f139ac93afc7e0328dd16cf
https://doi.org/10.1021/jm101228f
https://doi.org/10.1021/jm101228f
Autor:
Jose M. CoteroÌn, David Catterick, Julia Castro, MariÌa J. Chaparro, Beatriz DiÌaz, Esther FernaÌndez, Santiago Ferrer, Francisco J. Gamo, Mariola Gordo, Jiri Gut, Laura de las Heras, Jennifer Legac, Maria Marco, Juan Miguel, Vicente MunÌoz, Esther Porras, Juan C. de la Rosa, Jose R. Ruiz, Elena Sandoval, Pilar Ventosa
Publikováno v:
Journal of Medicinal Chemistry; Aug2010, Vol. 53 Issue 16, p6129-6152, 24p