Zobrazeno 1 - 10
of 428
pro vyhledávání: '"Juan C Troncoso"'
Autor:
Vijay R Varma, Youjin Wang, Yang An, Sudhir Varma, Murat Bilgel, Jimit Doshi, Cristina Legido-Quigley, João C Delgado, Anup M Oommen, Jackson A Roberts, Dean F Wong, Christos Davatzikos, Susan M Resnick, Juan C Troncoso, Olga Pletnikova, Richard O'Brien, Eelko Hak, Brenda N Baak, Ruth Pfeiffer, Priyanka Baloni, Siamak Mohmoudiandehkordi, Kwangsik Nho, Rima Kaddurah-Daouk, David A Bennett, Shahinaz M Gadalla, Madhav Thambisetty
Publikováno v:
PLoS Medicine, Vol 18, Iss 5, p e1003615 (2021)
BackgroundWhile Alzheimer disease (AD) and vascular dementia (VaD) may be accelerated by hypercholesterolemia, the mechanisms underlying this association are unclear. We tested whether dysregulation of cholesterol catabolism, through its conversion t
Externí odkaz:
https://doaj.org/article/2c8a7f7dbbcf4006bcc57756f0be9c11
Autor:
Uma V Mahajan, Vijay R Varma, Michael E Griswold, Chad T Blackshear, Yang An, Anup M Oommen, Sudhir Varma, Juan C Troncoso, Olga Pletnikova, Richard O'Brien, Timothy J Hohman, Cristina Legido-Quigley, Madhav Thambisetty
Publikováno v:
PLoS Medicine, Vol 17, Iss 10, p e1003439 (2020)
[This corrects the article DOI: 10.1371/journal.pmed.1003012.].
Externí odkaz:
https://doaj.org/article/c26c92150a414324b984fc7a7fd94c11
Autor:
Michael J Tisza, Diana V Pastrana, Nicole L Welch, Brittany Stewart, Alberto Peretti, Gabriel J Starrett, Yuk-Ying S Pang, Siddharth R Krishnamurthy, Patricia A Pesavento, David H McDermott, Philip M Murphy, Jessica L Whited, Bess Miller, Jason Brenchley, Stephan P Rosshart, Barbara Rehermann, John Doorbar, Blake A Ta'ala, Olga Pletnikova, Juan C Troncoso, Susan M Resnick, Ben Bolduc, Matthew B Sullivan, Arvind Varsani, Anca M Segall, Christopher B Buck
Publikováno v:
eLife, Vol 9 (2020)
Although millions of distinct virus species likely exist, only approximately 9000 are catalogued in GenBank's RefSeq database. We selectively enriched for the genomes of circular DNA viruses in over 70 animal samples, ranging from nematodes to human
Externí odkaz:
https://doaj.org/article/18258a977dad4b58af65b3c54e4dcb03
Autor:
Uma V Mahajan, Vijay R Varma, Michael E Griswold, Chad T Blackshear, Yang An, Anup M Oommen, Sudhir Varma, Juan C Troncoso, Olga Pletnikova, Richard O'Brien, Timothy J Hohman, Cristina Legido-Quigley, Madhav Thambisetty
Publikováno v:
PLoS Medicine, Vol 17, Iss 1, p e1003012 (2020)
BackgroundThere is growing evidence that Alzheimer disease (AD) is a pervasive metabolic disorder with dysregulation in multiple biochemical pathways underlying its pathogenesis. Understanding how perturbations in metabolism are related to AD is crit
Externí odkaz:
https://doaj.org/article/33544d8fb8e74884a376477c2e37891f
Autor:
Esther S Oh, Kaj Blennow, George E Bigelow, Sharon K Inouye, Edward R Marcantonio, Karin J Neufeld, Paul B Rosenberg, Juan C Troncoso, Nae-Yuh Wang, Henrik Zetterberg, Frederick E Sieber, Constantine G Lyketsos
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0204695 (2018)
BACKGROUND:There is strong association of Alzheimer's disease (AD) pathology with gait disorder and falls in older adults without dementia. The goal of the study was to examine the prevalence and severity of AD pathology in older adults without demen
Externí odkaz:
https://doaj.org/article/efffaacbc9934cb0a0576bfd04be3ae7
Autor:
Vijay R Varma, Anup M Oommen, Sudhir Varma, Ramon Casanova, Yang An, Ryan M Andrews, Richard O'Brien, Olga Pletnikova, Juan C Troncoso, Jon Toledo, Rebecca Baillie, Matthias Arnold, Gabi Kastenmueller, Kwangsik Nho, P Murali Doraiswamy, Andrew J Saykin, Rima Kaddurah-Daouk, Cristina Legido-Quigley, Madhav Thambisetty
Publikováno v:
PLoS Medicine, Vol 15, Iss 1, p e1002482 (2018)
BACKGROUND:The metabolic basis of Alzheimer disease (AD) is poorly understood, and the relationships between systemic abnormalities in metabolism and AD pathogenesis are unclear. Understanding how global perturbations in metabolism are related to sev
Externí odkaz:
https://doaj.org/article/22f7f44d5e424f9fae92e9cc4533ed09
Autor:
Mei-Fang Xiao, Desheng Xu, Michael T Craig, Kenneth A Pelkey, Chun-Che Chien, Yang Shi, Juhong Zhang, Susan Resnick, Olga Pletnikova, David Salmon, James Brewer, Steven Edland, Jerzy Wegiel, Benjamin Tycko, Alena Savonenko, Roger H Reeves, Juan C Troncoso, Chris J McBain, Douglas Galasko, Paul F Worley
Publikováno v:
eLife, Vol 6 (2017)
Memory loss in Alzheimer’s disease (AD) is attributed to pervasive weakening and loss of synapses. Here, we present findings supporting a special role for excitatory synapses connecting pyramidal neurons of the hippocampus and cortex with fast-spik
Externí odkaz:
https://doaj.org/article/c08345d0049e4dd1b942103924533d4a
Autor:
Rogger P. Carmen-Orozco, William Tsao, Yingzhi Ye, Irika R. Sinha, Koping Chang, Vickie T. Trinh, William Chung, Kyra Bowden, Juan C. Troncoso, Seth Blackshaw, Lindsey R. Hayes, Shuying Sun, Philip C. Wong, Jonathan P. Ling
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-17 (2024)
Abstract Background Cytoplasmic inclusions and loss of nuclear TDP-43 are key pathological features found in several neurodegenerative disorders, suggesting both gain- and loss-of-function mechanisms of disease. To study gain-of-function, TDP-43 over
Externí odkaz:
https://doaj.org/article/57aa4877bd6841eeb1d7825c31059ce8
Autor:
Maxime WC Rousseaux, Maria de Haro, Cristian A Lasagna-Reeves, Antonia De Maio, Jeehye Park, Paymaan Jafar-Nejad, Ismael Al-Ramahi, Ajay Sharma, Lauren See, Nan Lu, Luis Vilanova-Velez, Tiemo J Klisch, Thomas F Westbrook, Juan C Troncoso, Juan Botas, Huda Y Zoghbi
Publikováno v:
eLife, Vol 5 (2016)
Several neurodegenerative diseases are driven by the toxic gain-of-function of specific proteins within the brain. Elevated levels of alpha-synuclein (α-Syn) appear to drive neurotoxicity in Parkinson's disease (PD); neuronal accumulation of tau is
Externí odkaz:
https://doaj.org/article/93410c1594ba4a58af0e34be80ba8d24
Autor:
Przemysław R. Kac, Fernando González-Ortiz, Andreja Emeršič, Maciej Dulewicz, Srinivas Koutarapu, Michael Turton, Yang An, Denis Smirnov, Agnieszka Kulczyńska-Przybik, Vijay R. Varma, Nicholas J. Ashton, Laia Montoliu-Gaya, Elena Camporesi, Izabela Winkel, Bogusław Paradowski, Abhay Moghekar, Juan C. Troncoso, Tammaryn Lashley, Gunnar Brinkmalm, Susan M. Resnick, Barbara Mroczko, Hlin Kvartsberg, Milica Gregorič Kramberger, Jörg Hanrieder, Saša Čučnik, Peter Harrison, Henrik Zetterberg, Piotr Lewczuk, Madhav Thambisetty, Uroš Rot, Douglas Galasko, Kaj Blennow, Thomas K. Karikari
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Blood phosphorylated tau (p-tau) biomarkers, including p-tau217, show high associations with Alzheimer’s disease (AD) neuropathologic change and clinical stage. Certain plasma p-tau217 assays recognize tau forms phosphorylated additionally
Externí odkaz:
https://doaj.org/article/cd9a96562fae4bf787bc8b6e650f5603