Zobrazeno 1 - 10
of 443
pro vyhledávání: '"Juan C, Celedón"'
Autor:
Kristina Gaietto, MD MPH, Yueh-Ying Han, PhD, Franziska J. Rosser, MD, MPH, Edna Acosta-Pérez, PhD, Erick Forno, MD, MPH, Glorisa Canino, PhD, Juan C. Celedón, MD, DrPH, FAAAAI
Publikováno v:
Journal of Allergy and Clinical Immunology: Global, Vol 3, Iss 2, Pp 100220- (2024)
Background: Why Puerto Rican youths have higher rates of severe asthma exacerbations (SAEs) than their non-Hispanic White peers is unclear. Objective: We aimed to identify risk factors associated with recurrent SAEs in Puerto Rican youths with asthma
Externí odkaz:
https://doaj.org/article/6bac08af6ff4441781762db8ae9fffda
Autor:
Kevin M. Mendez, Sofina Begum, Anshul Tiwari, Rinku Sharma, Qingwen Chen, Rachel S. Kelly, Nicole Prince, Mengna Huang, Priyadarshini Kachroo, Su H. Chu, Yulu Chen, Kathleen Lee-Sarwar, David I. Broadhurst, Stacey N. Reinke, Robert Gerszten, Clary Clish, Lydiana Avila, Juan C. Celedón, Craig E. Wheelock, Scott T. Weiss, Michael McGeachie, Jessica A. Lasky-Su
Publikováno v:
EBioMedicine, Vol 102, Iss , Pp 105025- (2024)
Summary: Background: Lung function trajectories (LFTs) have been shown to be an important measure of long-term health in asthma. While there is a growing body of metabolomic studies on asthma status and other phenotypes, there are no prospective stud
Externí odkaz:
https://doaj.org/article/1da55660eee84901b30e4550ba08f293
Autor:
Zhaozhong Zhu, Yijun Li, Robert J. Freishtat, Juan C. Celedón, Janice A. Espinola, Brennan Harmon, Andrea Hahn, Carlos A. Camargo, Liming Liang, Kohei Hasegawa
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Bronchiolitis is the most common lower respiratory infection in infants, yet its pathobiology remains unclear. Here we present blood DNA methylation data from 625 infants hospitalized with bronchiolitis in a 17-center prospective study, and
Externí odkaz:
https://doaj.org/article/3fa02ad0977a4a968bb8333fd7819fee
Autor:
Daniel Aguilar, Nathanaël Lemonnier, Erik Melén, Mariona Bustamante, Olena Gruzieva, Stefano Guerra, Thomas Keil, Gerard H. Koppelman, Juan C. Celedón, Josep M. Antó, Jean Bousquet
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract The concept of “one-airway-one-disease”, coined over 20 years ago, may be an over-simplification of the links between allergic diseases. Genomic studies suggest that rhinitis alone and rhinitis with asthma are operated by distinct pathwa
Externí odkaz:
https://doaj.org/article/c58c66e4654f449b80a63b2c58eabe0f
Publikováno v:
ERJ Open Research, Vol 9, Iss 6 (2023)
Background α-Klotho is a pleiotropic protein that may have anti-oxidative and anti-inflammatory properties in the lung, but its role in airflow obstruction or lung function is largely unknown. Methods This was a cross-sectional study of 6046 adults
Externí odkaz:
https://doaj.org/article/857c241c18d14aab9383267da31fe2ff
Autor:
Merlijn van Breugel, Cancan Qi, Zhongli Xu, Casper-Emil T. Pedersen, Ilya Petoukhov, Judith M. Vonk, Ulrike Gehring, Marijn Berg, Marnix Bügel, Orestes A. Carpaij, Erick Forno, Andréanne Morin, Anders U. Eliasen, Yale Jiang, Maarten van den Berge, Martijn C. Nawijn, Yang Li, Wei Chen, Louis J. Bont, Klaus Bønnelykke, Juan C. Celedón, Gerard H. Koppelman, Cheng-Jian Xu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Accurate prediction of the onset of childhood allergy is important to clarify the difference between various respiratory diseases. Here the authors propose that the methylation status of three sites in nasal DNA predicts the onset of childhood allerg
Externí odkaz:
https://doaj.org/article/c100626637b74ab19f631fe608beaa08
Autor:
Michimasa Fujiogi, Yoshihiko Raita, Marcos Pérez-Losada, Robert J. Freishtat, Juan C. Celedón, Jonathan M. Mansbach, Pedro A. Piedra, Zhaozhong Zhu, Carlos A. Camargo, Kohei Hasegawa
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Bronchiolitis is major cause of infection, morbidity and hospitalisation. Here the authors apply transcriptomic based assessment of the host response, microbiome composition and function, and associate this to bronchiolitis severity.
Externí odkaz:
https://doaj.org/article/eb3de97ea67e48ba9b6b652ed2a65779
Autor:
Jaehyun Joo, Angel C. Y. Mak, Shujie Xiao, Patrick M. Sleiman, Donglei Hu, Scott Huntsman, Celeste Eng, Mengyuan Kan, Avantika R. Diwakar, Jessica A. Lasky-Su, Scott T. Weiss, Joanne E. Sordillo, Ann C. Wu, Michelle Cloutier, Glorisa Canino, Erick Forno, Juan C. Celedón, Max A. Seibold, Hakon Hakonarson, L. Keoki Williams, Esteban G. Burchard, Blanca E. Himes
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Variability in response to short-acting β2-agonists (e.g., albuterol) among patients with asthma from diverse racial/ethnic groups may contribute to asthma disparities. We sought to identify genetic variants associated with bronchodilator r
Externí odkaz:
https://doaj.org/article/808f2b5b81bf46269caaa117e076f965
Autor:
Raimon Rios, Thiago Magalhães da Silva, Agostino Strina, Erick Forno, Ryan Costa, Juan C. Celedón, Maurício L. Barreto, Camila Alexandrina Figueiredo
Publikováno v:
Heliyon, Vol 9, Iss 2, Pp e13659- (2023)
Genetic variants in filaggrin (FLG) are key in eczema and are less common in Africans than in Europeans and Asians. Here we examined the association between FLG Single Nucleotide Polymorphisms (SNPs) and eczema in a population of admixed Brazilian ch
Externí odkaz:
https://doaj.org/article/28e148a1da914046bb9fd89e12bc4886
Publikováno v:
Epigenetics, Vol 17, Iss 3, Pp 286-296 (2022)
Exposure to environmental factors can affect DNA methylation at a 5'-cytosine-phosphate-guanine-3' (CpG) site or a genomic region, which can then affect an outcome. In other words, environmental effects on an outcome could be mediated by DNA methylat
Externí odkaz:
https://doaj.org/article/bda50928fd4b45c4bf29f2ba2f8c8d0e