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Akademický článek

Generation of a high yield vaccine backbone for influenza B virus in embryonated chicken eggs

Autor: Sadaf Aslam, Madhusudan Rajendran, Divya Kriti, Andrew Kurland, Jeffrey Johnson, Harm van Bakel, Florian Krammer, Adolfo García-Sastre, Juan Ayllon

Publikováno v: npj Vaccines, Vol 8, Iss 1, Pp 1-11 (2023)

Abstract Influenza B virus (IBV) strains are one of the components of seasonal influenza vaccines in both trivalent and quadrivalent formulations. The vast majority of these vaccines are produced in embryonated chickens’ eggs. While optimized backb

Externí odkaz: https://doaj.org/article/8e8ff1a7efa0421bbf09605e53f8f825

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Akademický článek

Coronavirus as the Possible Causative Agent of the 1889–1894 Pandemic

Autor: Anton Erkoreka, Josu Hernando-Pérez, Juan Ayllon

Publikováno v: Infectious Disease Reports, Vol 14, Iss 3, Pp 453-469 (2022)

Using new and original nineteenth-century sources, we analysed the epidemiology, clinical features and virology of the 1889 pandemic, which was referred to at the time as ‘Russian flu’ or ‘Asiatic flu’. However, we rejected this identificatio

Externí odkaz: https://doaj.org/article/fc5fe62795304f19a6b0f61081ab3fbd

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Akademický článek

A novel small molecule inhibitor of influenza A viruses that targets polymerase function and indirectly induces interferon.

Autor: Mila Brum Ortigoza, Oliver Dibben, Jad Maamary, Luis Martinez-Gil, Victor H Leyva-Grado, Pablo Abreu, Juan Ayllon, Peter Palese, Megan L Shaw

Publikováno v: PLoS Pathogens, Vol 8, Iss 4, p e1002668 (2012)

Influenza viruses continue to pose a major public health threat worldwide and options for antiviral therapy are limited by the emergence of drug-resistant virus strains. The antiviral cytokine, interferon (IFN) is an essential mediator of the innate

Externí odkaz: https://doaj.org/article/2658e6b4c2e042d0aa9be6c8b270cfdb

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Akademický článek

Identification of small molecules with type I interferon inducing properties by high-throughput screening.

Autor: Luis Martínez-Gil, Juan Ayllon, Mila Brum Ortigoza, Adolfo García-Sastre, Megan L Shaw, Peter Palese

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e49049 (2012)

The continuous emergence of virus that are resistant to current anti-viral drugs, combined with the introduction of new viral pathogens for which no therapeutics are available, creates an urgent need for the development of novel broad spectrum antivi

Externí odkaz: https://doaj.org/article/c83f9e14a14e4285b7f1877177935f20

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Akademický článek

A transient homotypic interaction model for the influenza A virus NS1 protein effector domain.

Autor: Philip S Kerry, Juan Ayllon, Margaret A Taylor, Claudia Hass, Andrew Lewis, Adolfo García-Sastre, Richard E Randall, Benjamin G Hale, Rupert J Russell

Publikováno v: PLoS ONE, Vol 6, Iss 3, p e17946 (2011)

Influenza A virus NS1 protein is a multifunctional virulence factor consisting of an RNA binding domain (RBD), a short linker, an effector domain (ED), and a C-terminal 'tail'. Although poorly understood, NS1 multimerization may autoregulate its acti

Externí odkaz: https://doaj.org/article/1e53f468b4284a219d9d5eb9b117636c

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Electron Cyclotron stray radiation detector studies for JT-60SA

Autor: Alessandro Moro, Juan Ayllon, Lorenzo Figini, Saul Garavaglia, Ken Kajiwara, Takayuki Kobayashi, Carla Piccinni, Alessandro Simonetto, Carlo Sozzi, Hajime Urano, Maiko Yoshida

Publikováno v: Fusion Engineering and Design

Most of the present and future magnetic fusion devices rely on high power mm-waves injection for a variety of applications like plasma breakdown, heating and control. Since under specific operating conditions the mm-waves might not be fully absorbed,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d1d83ce451eda2d88360787e853bb09

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Activity of human serum antibodies in an influenza virus hemagglutinin stalk-based ADCC reporter assay correlates with activity in a CD107a degranulation assay

Autor: Arvind Rajabhathor, Maria Bermudez-Gonzalez, Viviana Simon, Bruno Salaun, Juan Ayllon, Veronika Chromikova, Florian Krammer, Sadaf Aslam, Jessica Tan, Adolfo García-Sastre, Raffael Nachbagauer

Publikováno v: Vaccine. 38:1953-1961

The stalk of the influenza virus hemagglutinin (HA) is an attractive target for antibody-based universal influenza virus vaccine development. While antibodies that target this part of the virus can be neutralizing, it has been shown in recent years t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd8c9d092f8e7aa5f8208c66ee58339e
https://doi.org/10.1016/j.vaccine.2020.01.008

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Pre-existing Hemagglutinin Stalk Antibodies Correlate with Protection of Lower Respiratory Symptoms in Flu-Infected Transplant Patients

Autor: Juan Ayllon, Adolfo García-Sastre, Javier Sánchez-Céspedes, Francisco López-Medrano, Elisa Cordero, Cristina Roca-Oporto, Florian Krammer, Shirin Strohmeier, Joan Gavaldà, Sadaf Aslam, Patricia Muñoz, Jordi Carratalà, Teresa Aydillo, Pilar Pérez-Romero, Alba Escalera, Miguel Montejo

Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)
Cell Reports Medicine
Dipòsit Digital de la UB
Universidad de Barcelona
Digital.CSIC. Repositorio Institucional del CSIC
instname

Summary Hemagglutination-inhibitory antibodies are usually highly strain specific with little effect on infection with drifted or shifted strains. The significance of broadly cross-reactive non-HAI anti-influenza antibodies against conserved domains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::786b7af99fbc2d4b7faebaa6fb62d892
http://hdl.handle.net/10261/235712

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