Carbohydrate-Based NK1R Antagonists with Broad-Spectrum Anticancer Activity

Autor: Patricia Lerena, Estefanía Burgos-Morón, Victoria Valdivia, José Manuel Calderón-Montaño, Juan Angel Organero, Rocío Recio, Manuel Leal, Bernard Mouillac, Esther Pozo, Miguel López-Lázaro, Noureddine Khiar, Inmaculada Fernández

Publikováno v: idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2021, 64 (14), pp.10350-10370. ⟨10.1021/acs.jmedchem.1c00793⟩

NK1R antagonists, investigated for the treatment of several pathologies, have shown encouraging results in the treatment of several cancers. In the present study, we report on the synthesis of carbohydrate-based NK1R antagonists and their evaluation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c95dc9ba4f24c972b745dc09dad5263a
https://doi.org/10.1021/acs.jmedchem.1c00793

Synthesis and Biological Evaluation of Ru(II) and Pt(II) Complexes Bearing Carboxyl Groups as Potential Anticancer Targeted Drugs

Autor: M. Pilar Carranza, Juan Angel Organero, Cristina Aliende, Iteng Ng-Choi, Lidia Feliu, Anna Massaguer, Ma Angeles Martínez, Lucía Santos, Blanca R. Manzano, Rafael de Llorens, Gustavo Espino, Marta Planas, Félix A. Jalón, Ana M. Rodríguez

Publikováno v: Inorganic Chemistry. 56:13679-13696

The synthesis and characterization of Pt(II) (1 and 2) and Ru(II) arene (3 and 4) or polypyridine (5 and 6) complexes is described. With the aim of having a functional group to form bioconjugates, one uncoordinated carboxyl group has been introduced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::483811f6ceea9f058e1df7423724bba7
https://doi.org/10.1021/acs.inorgchem.7b01178

Structural and photodynamic properties of the anti-cancer drug irinotecan in aqueous solutions of different pHs

Autor: Yasmin Douhal, Abderrazzak Douhal, Maria Rosaria di Nunzio, Juan Angel Organero

Publikováno v: Physical chemistry chemical physics : PCCP. 20(20)

This work reports on photophysical studies of the irinotecan (IRT) anti-cancer drug in water solutions of different acidities (pH = 1.11–9.46). We found that IRT co-exists as mono-cationic (C1), di-cationic (C2), or neutral (N) forms. The populatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed5135cf6c2b583962403be6a02a4e25
https://pubmed.ncbi.nlm.nih.gov/29761192

Real-Time Photodynamics of Squaraine-Based Dye-Sensitized Solar Cells with Iodide and Cobalt Electrolytes

Autor: Abderrazzak Douhal, Boiko Cohen, Maria Marchena, Shuzi Hayase, Gustavo de Miguel, Juan Angel Organero, Shyam S. Pandey

Publikováno v: The Journal of Physical Chemistry C. 117:11906-11919

A series of dye-sensitized solar cells (DSSCs) has been prepared by using indole-based or quinoline-based squaraines (SQs) as the sensitizer and containing the commonly used I3–/I– redox pair or the lately employed cobalt complexes, [Co(dimethylb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f53bea74222b49a1d9e480fa80f061f5
https://doi.org/10.1021/jp401399j

Excited state intermolecular proton and energy transfer of 1-hydroxypyrene interacting with the human serum albumin protein

Autor: Noemí Alarcos Carmona, Juan Angel Organero, Abderrazzak Douhal, Boiko Cohen

Publikováno v: Journal of Photochemistry and Photobiology A: Chemistry. 234:3-11

We report on pico to nanosecond studies of the excited-state intermolecular-proton transfer (ESPT) reaction and energy transfer of 1-hydroxypyrene (1-HP) with the human serum albumin (HSA) protein. The formed robust 1:1 complexes ( K eq = (1.84 ± 0.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b8b790c91f3b840986b5b5b2110ac82
https://doi.org/10.1016/j.jphotochem.2011.10.024