Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Juan Alejandro Oliva Trejo"'
Autor:
Chigure Suzuki, Junji Yamaguchi, Takahito Sanada, Juan Alejandro Oliva Trejo, Souichirou Kakuta, Masahiro Shibata, Isei Tanida, Yasuo Uchiyama
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Neuronal ceroid lipofuscinosis is one of many neurodegenerative storage diseases characterized by excessive accumulation of lipofuscins. CLN10 disease, an early infantile neuronal ceroid lipofuscinosis, is associated with a gene that encodes
Externí odkaz:
https://doaj.org/article/80b315c1956a493ba5fc85c460220874
Autor:
Isei Tanida, Yoko Furuta, Junji Yamaguchi, Soichiro Kakuta, Juan Alejandro Oliva Trejo, Yasuo Uchiyama
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Abstract In-resin CLEM of Epon embedded samples can greatly simplify the correlation of fluorescent images with electron micrographs. The usefulness of this technique is limited at present by the low number of fluorescent proteins that resist CLEM pr
Externí odkaz:
https://doaj.org/article/84e16da512444879bfc9d6a0294bd7cd
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 1, p 155 (2019)
Renal proximal tubular epithelial cells are significantly damaged during acute kidney injury. Renal proximal tubular cell-specific autophagy-deficient mice show increased sensitivity against renal injury, while showing few pathological defects under
Externí odkaz:
https://doaj.org/article/b621eaeead56454680cbb1ce5bfd9214
Autor:
Chigure Suzuki, Isei Tanida, Masaki Ohmuraya, Juan Alejandro Oliva Trejo, Soichiro Kakuta, Takehiko Sunabori, Yasuo Uchiyama
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 7, p 1711 (2019)
Cathepsin D is one of the major lysosomal aspartic proteases that is essential for the normal functioning of the autophagy-lysosomal system. In the kidney, cathepsin D is enriched in renal proximal tubular epithelial cells, and its levels increase du
Externí odkaz:
https://doaj.org/article/9287afad05554ac8b1e80db60a354426
Autor:
Takuto Seki, Katsuhiko Asanuma, Rin Asao, Kanae Nonaka, Yu Sasaki, Juan Alejandro Oliva Trejo, Hiroyuki Kurosawa, Yoshiaki Hirayama, Satoshi Horikoshi, Yasuhiko Tomino, Akihiko Saito
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114400 (2014)
BACKGROUND AND OBJECTIVES: Megalin is highly expressed at the apical membranes of proximal tubular epithelial cells. A urinary full-length megalin (C-megalin) assay is linked to the severity of diabetic nephropathy in type 2 diabetes. This study exam
Externí odkaz:
https://doaj.org/article/8f571254781548b99ea04e1497d4a3d2
Autor:
Mitsuo Suga, Yoko Furuta, Soichiro Kakuta, Akira Takebe, Yasuo Uchiyama, Tomohiro Haruta, Isei Tanida, Juan Alejandro Oliva Trejo, Shunsuke Takei, Junji Yamaguchi
Publikováno v:
J Histochem Cytochem
During autophagy, autophagosomes are formed to engulf cytoplasmic contents. p62/SQSTM-1 is an autophagic adaptor protein that forms p62 bodies. A unique feature of p62 bodies is that they seem to directly associate with membranous structures. We firs
Autor:
Shunichi Matsumoto, Masanobu Yamada, Eijiro Yamada, Atsushi Ozawa, Tetsurou Satoh, Satoru Kakizaki, Yasuo Uchiyama, Juan Alejandro Oliva Trejo, Yusaku Iwasaki, Masatomo Mori, Satoshi Yoshino
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive accumulation of hepatic triglycerides (TG) and hyperglycemia arising due to persistent insulin resistance, and is profoundly linked to obesity. However, there is currently no esta
Autor:
Juan Alejandro Oliva Trejo, Isei Tanida, Yasuo Uchiyama, Norihiro Tada, Chigure Suzuki, Soichiro Kakuta
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
We generated a new transgenic mouse model that expresses a pHluorin-mKate2 fluorescent protein fused with human LC3B (PK-LC3 mice) for monitoring autophagy activity in neurons of the central nervous system. Histological analysis revealed fluorescent
Autor:
Chigure, Suzuki, Junji, Yamaguchi, Takahito, Sanada, Juan Alejandro, Oliva Trejo, Souichirou, Kakuta, Masahiro, Shibata, Isei, Tanida, Yasuo, Uchiyama
Neuronal ceroid lipofuscinosis is one of many neurodegenerative storage diseases characterized by excessive accumulation of lipofuscins. CLN10 disease, an early infantile neuronal ceroid lipofuscinosis, is associated with a gene that encodes cathepsi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b937f802e87b071be5978ec22de952f2
https://doi.org/10.21203/rs.3.rs-1080356/v1
https://doi.org/10.21203/rs.3.rs-1080356/v1
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Post-fixation with osmium tetroxide staining and the embedding of Epon are robust and essential treatments that are used to preserve and visualize intracellular membranous structures during electron microscopic analyses. These treatments, however, ca