Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Juan A. Sánchez-Arias"'
Autor:
Mar Cuadrado-Tejedor, Marta Pérez-González, Cristina García-Muñoz, Damián Muruzabal, Carolina García-Barroso, Obdulia Rabal, Víctor Segura, Juan A. Sánchez-Arias, Julen Oyarzabal, Ana Garcia-Osta
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
The discouraging results with therapies for Alzheimer’s disease (AD) in clinical trials, highlights the urgent need to adopt new approaches. Like other complex diseases, it is becoming clear that AD therapies should focus on the simultaneous modula
Externí odkaz:
https://doaj.org/article/406af94d56d34149a280e4d9333bb21a
Publikováno v:
Frontiers in Neuroanatomy, Vol 12 (2018)
Gaucher’s disease (GD) is the most prevalent lysosomal storage disorder. GD is caused by homozygous mutations of the GBA1 gene, which codes for beta-glucocerebrosidase (GCase). Although GD primarily affects peripheral tissues, the presence of neuro
Externí odkaz:
https://doaj.org/article/1be996fb41b041ec91d94f024a9e67fa
Autor:
José A. Rodríguez, Tomás Sobrino, Esteban López‐Arias, Ana Ugarte, Juan A. Sánchez‐Arias, Alba Vieites‐Prado, Irene de Miguel, Julen Oyarzabal, José A. Páramo, Francisco Campos, Josune Orbe, José Castillo
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 6 (2017)
BackgroundIntracerebral hemorrhage (ICH) is an acute neurological disorder with high mortality and no effective treatment. In addition to the initial bleeding event, rebleeding and hematoma expansion are associated with poor outcome in these patients
Externí odkaz:
https://doaj.org/article/500c185b31c94d6aa4d56a8f1631e56d
Autor:
Elena Sáez, Musheng Xu, Raquel Ordoñez, Amaia Vilas-Zornoza, Feifei Zhang, Xabier Agirre, Antonio Pineda-Lucena, Obdulia Rabal, Julen Oyarzabal, Felipe Prosper, Edurne San José-Enériz, Estíbaliz Miranda, Irene de Miguel, Leire Garate, Juan A. Sánchez-Arias, Ander Estella, Wei Wu
Publikováno v:
Journal of Medicinal Chemistry. 64:3392-3426
Concomitant inhibition of key epigenetic pathways involved in silencing tumor suppressor genes has been recognized as a promising strategy for cancer therapy. Herein, we report a first-in-class series of quinoline-based analogues that simultaneously
Autor:
Ane Mínguez-Olaondo, Ivan Martinez-Valbuena, Pablo Irimia, Rogelio Leira, Clara Domínguez-Vivero, Maria-Rosario Luquin, Juan-Antonio Sánchez-Arias, Eduardo Martínez-Vila
Publikováno v:
Cephalalgia. 41:604-612
Background Recently, amylin and its receptors were found in different structures involved in migraine pathophysiology. Here, we evaluate interictal concentrations of amylin and calcitonin gene-related peptide in peripheral blood as biomarkers for chr
Autor:
Maria-Teresa Tuñon, Carlos E. de Andrea, Rafael Valenti-Azcarate, Maria-Rosario Luquin, Mario Riverol, Ivan Martinez-Valbuena, Juan A. Sánchez-Arias, Irene Marcilla, Irene Amat-Villegas, M.M. Carmona-Abellán, Eduardo Martínez-Vila, Maria-Elena Erro, Gloria Marti
Publikováno v:
Annals of Neurology. 86:539-551
Objective Alzheimer disease (AD) is the leading cause of dementia, and although its etiology remains unclear, it seems that type 2 diabetes mellitus (T2DM) and other prediabetic states of insulin resistance could contribute to the appearance of spora
Autor:
Gemma Navarro, José Luis Lanciego, Rafael Franco, Juan A. Sánchez-Arias, Julen Oyarzabal, Eva Martínez-Pinilla, Alberto J Rico, David Aguinaga
Publikováno v:
Molecular Neurobiology. 56:5900-5910
Cannabinoid CB1 receptors (CB1R) and the GPR55 receptor are expressed in striatum and are potential targets in the therapy of Parkinson's disease (PD), one of the most prevalent neurodegenerative diseases in developed countries. The aim of this paper
Autor:
Obdulia, Rabal, Edurne, San José-Enériz, Xabier, Agirre, Juan Antonio, Sánchez-Arias, Irene, de Miguel, Raquel, Ordoñez, Leire, Garate, Estíbaliz, Miranda, Elena, Sáez, Amaia, Vilas-Zornoza, Antonio, Pineda-Lucena, Ander, Estella, Feifei, Zhang, Wei, Wu, Musheng, Xu, Felipe, Prosper, Julen, Oyarzabal
Publikováno v:
Journal of medicinal chemistry. 64(6)
Concomitant inhibition of key epigenetic pathways involved in silencing tumor suppressor genes has been recognized as a promising strategy for cancer therapy. Herein, we report a first-in-class series of quinoline-based analogues that simultaneously
Autor:
Ana Garcia-Osta, Irene de Miguel, Carolina García-Barroso, Julen Oyarzabal, Elena Sáez, Obdulia Rabal, Marta Pérez-González, Mar Cuadrado-Tejedor, Wu Wei, Maria Espelosin, Tan Haizhong, Ana Ugarte, Ander Estella-Hermoso de Mendoza, Susana Ursua, Juan A. Sánchez-Arias, Xu Musheng
Publikováno v:
European Journal of Medicinal Chemistry. 150:506-524
We have identified chemical probes that act as dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors (>1 log unit difference versus class I HDACs) to decipher the contribution of HDAC isoforms to the positive impact o
Autor:
Julen Oyarzabal, Elizabeth Guruceaga, Ramón Lecumberri, José Hermida, Mikel Allende, Juan A. Sánchez-Arias, Ana Ugarte, Eva Molina
Publikováno v:
Thrombosis and Haemostasis. 117:1722-1729
SummaryAntithrombotic medications target coagulation factors. Their use is associated with an increased bleeding risk. Safer drugs are needed. The heat shock protein 70 (Hsp70) exhibits antithrombotic properties that do not influence bleeding. By usi